{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:46:51Z","timestamp":1777650411253,"version":"3.51.4"},"reference-count":26,"publisher":"BMJ","issue":"17","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2018,1,29]]},"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Infection of valved aortic grafts is a rare entity whose diagnosis remains challenging. Positron emission tomography (PET)\/CT has become a criterion for the diagnosis of infective endocarditis (IE) in prosthetic valves, but its role on ascending aortic graft infections remains unclear. This study aims to assess the diagnostic value of PET\/CT in patients with valved aortic graft infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>12 episodes with a valved aortic graft who had undergone a PET\/CT due to suspicion of IE were prospectively included (group I) and compared with five controls free of infection who underwent PET\/CT for other reasons (group II). Pathological uptake of <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) and its pattern at the prosthetic valve and aortic graft were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Diagnosis of IE was confirmed in 9 out of 12 episodes of group I. <jats:sup>18<\/jats:sup>F-FDG uptake was detectable in eight out of nine cases with a final diagnosis of IE. The most repeated pattern of uptake was homogeneous around the valve and heterogeneous around the tube. There was one false-negative study. Of the three patients in which IE was ruled out, there were two false positives and one true negative. In group II, there were three patients with a positive PET\/CT study, two of them had active aortitis and the third was considered false positive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>\n                     <jats:sup>18<\/jats:sup>F-FDG PET\/CT shows high sensitivity in the detection of infected aortic grafts. Thus, this technique should be considered in the diagnostic work-up of patients with suspicion of aortic graft infection. However, further validation of this approach is needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2017-312918","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T12:29:00Z","timestamp":1519302540000},"page":"1447-1454","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Usefulness of positron emission tomography\/computed tomography in patients with valve-tube graft infection"],"prefix":"10.1136","volume":"104","author":[{"given":"Daniel","family":"Garc\u00eda-Arribas","sequence":"first","affiliation":[{"name":"Instituto Cardiovascular, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidre","family":"Vilacosta","sequence":"additional","affiliation":[{"name":"Instituto Cardiovascular, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Ortega Candil","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rodr\u00edguez Rey","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Olmos","sequence":"additional","affiliation":[{"name":"Instituto Cardiovascular, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jes\u00fas","family":"P\u00e9rez Castej\u00f3n","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Vivas","sequence":"additional","affiliation":[{"name":"Instituto Cardiovascular, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Nicol\u00e1s","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto Cardiovascular, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Carnero-Alc\u00e1zar","sequence":"additional","affiliation":[{"name":"Instituto Cardiovascular, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fern\u00e1ndez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Nuclear, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdSSC), Madrid, Spain"},{"name":"Servicio de Medicina Preventiva, Instituto de Investigaci\u00f3n Sanitaria Hospital Cl\u00ednico San Carlos (IdSSC), Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Maroto","sequence":"additional","affiliation":[{"name":"Instituto Cardiovascular, 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