{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:48:56Z","timestamp":1792608536629,"version":"4.5.0"},"reference-count":27,"publisher":"BMJ","issue":"6","funder":[{"DOI":"10.13039\/501100006212","name":"Hellenic Cardiological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2018,8,30]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Despite the progress in the management of patients with adult congenital heart disease (ACHD), a significant proportion of patients still develop pulmonary hypertension (PH). We aimed to highlight the rate of the complications in PH-ACHD and the predicting factors of cumulative mortality risk in this population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were obtained from the cohort of the national registry of ACHD in Greece from February 2012 until January 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 65 patients receiving PH-specific therapy were included (mean age 46.1\u00b114.4 years, 64.6% females). Heavily symptomatic (New York Heart Association (NYHA) class III\/IV) were 53.8% of patients. The majority received monotherapy, while combination therapy was administered in 41.5% of patients. Cardiac arrhythmia was reported in 30.8%, endocarditis in 1.5%, stroke in 4.6%, pulmonary arterial thrombosis in 6.2%, haemoptysis in 3.1% and hospitalisation due to heart failure (HF) in 23.1%. Over a median follow-up of 3 years (range 1\u20136), 12 (18.5%) patients died. On univariate Cox regression analysis history of HF hospitalisation emerged as a strong predictor of mortality (HR 8.91, 95% CI 2.64 to 30.02, p&lt;0.001), which remained significant after adjustment for age and for NYHA functional class.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Long-term complications are common among patients with PH-ACHD. Hospitalisations for HF predict mortality and should be considered in the risk stratification of this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2018-313613","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T12:15:34Z","timestamp":1538223334000},"page":"465-469","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Hospitalisations for heart failure predict mortality in pulmonary hypertension related to congenital heart disease"],"prefix":"10.1136","volume":"105","author":[{"given":"Despoina","family":"Ntiloudi","sequence":"first","affiliation":[{"name":"Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiria","family":"Apostolopoulou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and ACHD, Onassis Cardiac Surgery Center, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Vasiliadis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Hospital \u2019George Papanikolaou', Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Frogoudaki","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology, Attikon University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aphrodite","family":"Tzifa","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease, Mitera Children\u2019s Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Ntellos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tzaneio General Hospital of Piraeus, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Brili","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ippokrateion University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Manginas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mediterraneo Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Pitsis","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, St Luke\u2019s Hospital, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Kolios","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haralambos","family":"Karvounis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AHEPA University Hospital, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costas","family":"Tsioufis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ippokrateion University Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Goudevenos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Ioannina, Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyridon","family":"Rammos","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and ACHD, Onassis Cardiac Surgery Center, Athens, 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