{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:54:38Z","timestamp":1789397678261,"version":"build-2803163510"},"reference-count":17,"publisher":"BMJ","issue":"7","funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[2018,10,10]]},"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tachyarrhythmias and bradyarrhythmias affect 20%\u201350% of adult patients with tetralogy of Fallot (TOF) and some of these patients will require cardiac implantable electronic devices (CIED) such as pacemaker and\/or internal cardioverter defibrillator.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Mayo Adult Congenital Heart Disease database was queried for patients with repaired TOF and history of CIED implantation, 1990\u20132017. The study objectives were: (1) determine the occurrence of device-related complications defined as lead failure, lead recall, device infection and lead thrombus; and (2) determine the occurrence and risk factors for defibrillator shock.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 99 patients (age 46\u00b114 years and 66 (66%) men) with CIED, and the CIEDs were 41 (41%) pacemakers and 73 (73%) defibrillators. Indication for defibrillator implantation was for primary prevention in 28 (38%) and secondary prevention in 45 (62%). Device-related complications occurred in 20 (20%) patients (lead failure 17, lead recall 4, device infection 12 and thrombus 3). Twenty-five per cent of all device infections occurred within 30 days from the time of device generator change. Annualised rates of appropriate and inappropriate shocks were 5.7% and 6.2%, respectively. The use of class III antiarrhythmic drug was protective against defibrillator shock.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The current study provides useful outcome data to aid patient counselling and clinical decision-making. Further studies are required to explore ways to decrease the risk of postprocedural infection after device generator change, and to determine which patients will benefit from empirical antiarrhythmic therapy as a strategy to decrease incidence of inappropriate defibrillator shock.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/heartjnl-2018-314072","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T12:15:41Z","timestamp":1540901741000},"page":"538-544","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Cardiac implantable electronic devices in adults with tetralogy of Fallot"],"prefix":"10.1136","volume":"105","author":[{"given":"Alexander C","family":"Egbe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malini","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naser M","family":"Ammash","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkata R","family":"Missula","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Otaibi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayotola","family":"Fatola","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Kothapalli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi M","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"2025092012524431000_105.7.538.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308263290901"},{"key":"2025092012524431000_105.7.538.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00318-5"},{"key":"2025092012524431000_105.7.538.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.548727"},{"key":"2025092012524431000_105.7.538.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02714-8"},{"key":"2025092012524431000_105.7.538.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000138397.60956.c2"},{"key":"2025092012524431000_105.7.538.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.10.049"},{"key":"2025092012524431000_105.7.538.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02344-6"},{"key":"2025092012524431000_105.7.538.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.726372"},{"key":"2025092012524431000_105.7.538.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.659664"},{"key":"2025092012524431000_105.7.538.10","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304958"},{"key":"2025092012524431000_105.7.538.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.928481"},{"key":"2025092012524431000_105.7.538.12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijcard.2017.07.055","article-title":"Implantable cardioverter defibrillator therapy in repaired tetralogy of Fallot after pulmonary valve replacement: Implications for the mechanism of ventricular arrhythmia","volume":"249","author":"Chiu","year":"2017","journal-title":"Int J Cardiol"},{"key":"2025092012524431000_105.7.538.13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1253\/circj.CJ-16-0932","article-title":"Long-term efficacy of implantable cardioverter defibrillator in repaired tetralogy of fallot-role of anti-tachycardia pacing","volume":"81","author":"Henmi","year":"2017","journal-title":"Circ J"},{"key":"2025092012524431000_105.7.538.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.033"},{"key":"2025092012524431000_105.7.538.15","doi-asserted-by":"crossref","unstructured":"Stout KK , Daniels CJ , Aboulhosn JA , et al . 2018 AHA\/ACC guideline for the management of adults with congenital heart disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2018.doi:10.1016\/j.jacc.2018.08.1029","DOI":"10.1016\/j.jacc.2018.08.1029"},{"key":"2025092012524431000_105.7.538.16","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-311650"},{"key":"2025092012524431000_105.7.538.17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq497"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/heartjnl-2018-314072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:52:56Z","timestamp":1758397976000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/heartjnl-2018-314072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,30]]},"references-count":17,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,3,19]]},"published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1136\/heartjnl-2018-314072"],"URL":"https:\/\/doi.org\/10.1136\/heartjnl-2018-314072","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,30]]}}}