{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:06:26Z","timestamp":1765886786576,"version":"build-2065373602"},"reference-count":30,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2003,10,27]]},"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>\n                  <jats:bold>Objectives:<\/jats:bold> To determine the impact of moderate alcohol consumption on long term prognosis after successful coronary stenting, and whether it could be related to preprocedural plasma C reactive protein (CRP).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Part of the prospectively designed GENERATION study which investigated the impact of several biochemical factors, including plasma CRP, on long term prognosis after coronary stenting.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Tertiary referral centre.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> 483 consecutive patients with stable or unstable coronary artery disease who underwent successful coronary stenting and were followed for up to four years. Information about alcohol consumption was collected prospectively.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Interventions:<\/jats:bold> Successful coronary stenting.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Main outcome measures:<\/jats:bold> The incidence of the composite end point of readmission to hospital for unstable angina, non-fatal myocardial infarction, or cardiac death, whichever occurred first.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> By the end of follow up the incidence of the composite end point was 22.8%. Patients with a baseline plasma CRP concentration of &lt; 0.68 mg\/dl (defined by ROC analysis) did not show any difference in the composite end point (p \u200a=\u200a 0.9) or its components, regardless of the amount of alcohol consumed during follow up. However, among patients with plasma CRP concentration of \u2a7e 0.68 mg\/dl, those who drank moderately had a lower incidence of the composite end point (p &lt; 0.001) or its components.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Moderate alcohol consumption may have a beneficial impact on the long term prognosis following successful coronary stenting. The extent of this effect is positively related to preprocedural inflammatory status. An anti-inflammatory action of moderate alcohol consumption cannot be excluded.<\/jats:p>","DOI":"10.1136\/hrt.2003.016337","type":"journal-article","created":{"date-parts":[[2004,3,12]],"date-time":"2004-03-12T17:43:09Z","timestamp":1079113389000},"page":"419-424","source":"Crossref","is-referenced-by-count":21,"title":["C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study"],"prefix":"10.1136","volume":"90","author":[{"given":"M N","family":"Zairis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tzanio Hospital, Piraeus, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Ambrose","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Comprehensive Cardiovascular Center, Saint Vincent Catholic Medical Centers, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A 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