{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:23:57Z","timestamp":1770071037669,"version":"3.49.0"},"reference-count":22,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p>\n                  <jats:bold>Objectives:<\/jats:bold> To investigate the characteristics of the acute coronary syndromes underlying acute pulmonary oedema and their 30 day prognosis.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> 185 consecutive patients with acute coronary syndromes and acute pulmonary oedema admitted to a tertiary care centre.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Main outcome and measures:<\/jats:bold> Clinical, ECG, echocardiographic, enzymatic, and angiographic features were prospectively investigated.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Non-ST segment elevation myocardial infarction (NSTEMI) was the most frequent cause of acute pulmonary oedema (61%) followed by unstable angina (UA; 21%) and ST segment elevation myocardial infarction (STEMI; 18%). In each group, mean age was \u2a7e 70 years, but NSTEMI patients were the oldest and \u2a7e 65% of patients had chronic hypertension. Moreover, patients with NSTEMI and UA were older and had a higher incidence of diabetes, previous myocardial infarction, and moderate to severe mitral regurgitation but a similarly reduced ejection fraction (NSTEMI, 41%; UA, 39%; and STEMI, 39%) and increased incidence of diastolic dysfunction and rate of multivessel disease (94%, 87%, and 86%, respectively). However, patients with STEMI had a higher creatine kinase MB peak concentration (158 <jats:italic>v<\/jats:italic> 76 \u03bcg\/l in the NSTEMI group, p &lt; 0.001) and 30 day mortality (26% <jats:italic>v<\/jats:italic> 9% in the NSTEMI group and 8% in the UA group, p &lt; 0.024). Multivariate analysis identified ejection fraction &lt; 40% and a peak creatine kinase MB concentration &gt; 100 \u03bcg\/l as the main prognostic markers (p &lt; 0.03).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Acute pulmonary oedema is mostly a complication of elderly hypertensive patients with NSTEMI or UA (82%) and with multivessel disease often associated with mitral regurgitation. On the other hand, the larger infarct size and higher mortality in patients with STEMI with a similarly reduced ejection fraction suggest a more extensive acute systolic loss.<\/jats:p>","DOI":"10.1136\/hrt.2004.043703","type":"journal-article","created":{"date-parts":[[2005,6,15]],"date-time":"2005-06-15T06:15:46Z","timestamp":1118816146000},"page":"889-893","source":"Crossref","is-referenced-by-count":9,"title":["Thirty day prognosis of patients with acute pulmonary oedema complicating acute coronary syndromes"],"prefix":"10.1136","volume":"91","author":[{"given":"J","family":"Figueras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Soler-Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2005,6,14]]},"reference":[{"key":"2025101710273968000_91.7.889.1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360150095011"},{"key":"2025101710273968000_91.7.889.2","unstructured":"GISSI Investigators. Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Gruppo Italiano per lo Studio della Streptochinasi nell\u2019Infarto Miocardico (GISSI). Lancet 1987; ii :871\u20134."},{"key":"2025101710273968000_91.7.889.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1659"},{"key":"2025101710273968000_91.7.889.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00536-5"},{"key":"2025101710273968000_91.7.889.5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)91213-5"},{"key":"2025101710273968000_91.7.889.6","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJM198511073131906","volume":"313","year":"1985","journal-title":"N Engl J Med"},{"key":"2025101710273968000_91.7.889.7","doi-asserted-by":"publisher","DOI":"10.1097\/00019501-199206000-00011"},{"key":"2025101710273968000_91.7.889.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90058-6"},{"key":"2025101710273968000_91.7.889.9","first-page":"33","volume":"60","year":"1987","journal-title":"Am J Cardiol"},{"key":"2025101710273968000_91.7.889.10","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200002000-00007"},{"key":"2025101710273968000_91.7.889.11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.CIR.67.2.330","volume":"67","year":"1983","journal-title":"Circulation"},{"key":"2025101710273968000_91.7.889.12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJM198501313120504","volume":"312","year":"1985","journal-title":"N Engl J Med"},{"key":"2025101710273968000_91.7.889.13","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90053-3"},{"key":"2025101710273968000_91.7.889.14","first-page":"947","volume":"129","year":"1972","journal-title":"Arch Intern Med"},{"key":"2025101710273968000_91.7.889.15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1161\/01.CIR.59.5.955","volume":"59","year":"1979","journal-title":"Circulation"},{"key":"2025101710273968000_91.7.889.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431303"},{"key":"2025101710273968000_91.7.889.17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025609.13806.31"},{"key":"2025101710273968000_91.7.889.18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijcard.2003.04.035","volume":"94","year":"2004","journal-title":"Int J Cardiol"},{"key":"2025101710273968000_91.7.889.19","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(67)90023-9"},{"key":"2025101710273968000_91.7.889.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)07403-6"},{"key":"2025101710273968000_91.7.889.21","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.5.1220"},{"key":"2025101710273968000_91.7.889.22","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90318-F"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2004.043703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:27:48Z","timestamp":1760722068000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2004.043703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,14]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2005,6,14]]},"published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1136\/hrt.2004.043703"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2004.043703","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,14]]}}}