{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:31:42Z","timestamp":1789723902902,"version":"4.0.1"},"reference-count":25,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To evaluate non-atherosclerotic cardiac deaths in the UK population aged over 15 years including elderly patients and to highlight the concept of the structurally normal heart in sudden death.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Pathological data were collected prospectively for sudden adult deaths referred by UK coroners.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    453 cases of sudden death from 1994 to 2003 (278 men (61.4%) and 175 women (38.6%), age range 15\u201381 years) were reviewed. Males predominated in both age groups (\u2a7d 35 years, &gt; 35 years). More than half of the hearts (n \u200a=\u200a 269, 59.3%) were structurally normal. In the other 40.7%, cardiac abnormalities were noted, which included: (1) cardiomyopathies (23%) such as idiopathic fibrosis, left ventricular hypertrophy, hypertrophic cardiomyopathy, dilated cardiomyopathy, and arrhythmogenic right ventricular dysplasia; (2) inflammatory disorders (8.6%) including lymphocytic myocarditis and cardiac sarcoidosis; (3) non-atheromatous abnormalities of coronary arteries (4.6%); (4) valve diseases; and (5) miscellaneous and rare causes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The concept of the structurally normal heart in sudden death and the need for histological examination to detect underlying disease is highlighted. Relatives need to be referred for cardiological and genetic screening in cases of normal hearts found at necropsy.\n                  <\/jats:p>","DOI":"10.1136\/hrt.2004.045518","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T22:06:34Z","timestamp":1117231594000},"page":"316-320","source":"Crossref","is-referenced-by-count":267,"title":["Sudden adult death syndrome and other non-ischaemic causes of sudden cardiac death"],"prefix":"10.1136","volume":"92","author":[{"given":"A","family":"Fabre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M N","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,5,27]]},"reference":[{"key":"2025091921341142000_92.3.316.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90229-8"},{"key":"2025091921341142000_92.3.316.2","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1136\/bmj.297.6661.1453","volume":"297","year":"1988","journal-title":"BMJ"},{"key":"2025091921341142000_92.3.316.3","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg038"},{"key":"2025091921341142000_92.3.316.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.54.073002.182112"},{"key":"2025091921341142000_92.3.316.5","unstructured":"Sheppard MN. Sudden adult death and the heart. In: Kirkham NSN, ed. Progress in pathology. 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