{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:40:01Z","timestamp":1787017201871,"version":"build-2736575974"},"reference-count":28,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,2]]},"abstract":"\n Objective:<\/jats:bold>\n To evaluate the relative merits of viability and ischaemia for prognosis after revascularisation.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n Low\u2013high dose dobutamine stress echocardiography (DSE) was performed before revascularisation in 128 consecutive patients with ischaemic cardiomyopathy (mean (SD) left ventricular ejection fraction (LVEF) 31 (8)%). Viability (defined as contractile reserve (CR)) and ischaemia were assessed during low and high dose dobutamine infusion, respectively. Cardiac death was evaluated during a five year follow up. Clinical, angiographic, and echocardiographic data were analysed to identify predictors of events.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Univariable predictors of cardiac death were the presence of multivessel disease (hazard ratio (HR) 0.21, p < 0.001), baseline LVEF (HR 0.90, p < 0.0001), wall motion score index (WMSI) at rest (HR 4.02, p \u200a=\u200a 0.0006), low dose DSE (HR 7.01, p < 0.0001), peak dose DSE (HR 4.62, p < 0.0001), the extent of scar (HR 1.39, p < 0.0001), and the presence of CR in \u2a7e 25% of dysfunctional segments (HR 0.34, p \u200a=\u200a 0.02). The best multivariable model to predict cardiac death included the presence of multivessel disease, WMSI at low dose DSE, and the presence of CR in \u2a7e 25% of the severely dysfunctional segments (HR 9.62, p < 0.0001). Inclusion of ischaemia in the model did not provide additional predictive value.\n <\/jats:p>\n \n Conclusion:<\/jats:bold>\n The findings of the present study illustrate that in patients with ischaemic cardiomyopathy, the extent of viability (CR) is a strong predictor of long term prognosis after revascularisation. Ischaemia did not add significantly in predicting outcome.\n <\/jats:p>","DOI":"10.1136\/hrt.2004.055798","type":"journal-article","created":{"date-parts":[[2005,4,6]],"date-time":"2005-04-06T20:24:10Z","timestamp":1112819050000},"page":"239-244","source":"Crossref","is-referenced-by-count":60,"title":["Long term prognostic value of myocardial viability and ischaemia during dobutamine stress echocardiography in patients with ischaemic cardiomyopathy undergoing coronary revascularisation"],"prefix":"10.1136","volume":"92","author":[{"given":"V","family":"Rizzello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Poldermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F 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