{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:48:16Z","timestamp":1761947296991,"version":"build-2065373602"},"reference-count":34,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To study the cardiac geometric changes after transcatheter closure of large atrial septal defects (ASDs) according to patient age at the time of the procedure.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Prospective echocardiographic follow-up study.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Tertiary referral centre.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients and intervention:<\/jats:bold> 25 asymptomatic patients younger than 16 years (median 8 years; group 1) and 21 asymptomatic adults (median 38 years; group 2) underwent percutaneous closure of large ASD with the Amplatzer septal occluder device (mean 25 (SD 7) mm).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Main outcome measures:<\/jats:bold> Cardiac remodelling was assessed by M mode and two dimensional echocardiography one and six months after ASD closure.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> By six months, right atrial volume decreased from 31 (15) to 19 (5) ml\/m<jats:sup>2<\/jats:sup> (p &lt; 0.001) and right ventricular (RV) transverse diameter decreased from 29.8 (8.6) to 23.2 (5.6) mm\/m<jats:sup>2<\/jats:sup> (p &lt; 0.001). Conversely, left atrial volume did not change significantly (from 18 (6) to 20 (6) ml\/m<jats:sup>2<\/jats:sup>, NS) and left ventricular (LV) transverse diameter increased from 27.8 (6.4) to 31.8 (7.3) mm\/m<jats:sup>2<\/jats:sup> (p &lt; 0.05). Ventricular remodelling resulted in an RV:LV diameter ratio decrease from 1.1 (0.2) to 0.7 (0.1) (p &lt; 0.001). The magnitude and time course of cardiac remodelling did not differ significantly between the age groups. Indeed, right atrial volume decreased by 33 (26)% versus 37 (23)%, RV diameter decreased by 26 (10)% versus 20 (13)%, LV diameter increased by 17 (15)% versus 15 (10)%, and RV:LV diameter ratio decreased by 36 (8)% versus 27 (15)% in groups 1 and 2, respectively.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Cardiac remodelling after percutaneous ASD closure seems to be independent of the patient\u2019s age at the time of the procedure up to early adulthood. Thus, postponing ASD closure for a few years may be a reasonable option for potentially suitable asymptomatic children.<\/jats:p>","DOI":"10.1136\/hrt.2005.070169","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T20:33:32Z","timestamp":1134160412000},"page":"958-962","source":"Crossref","is-referenced-by-count":37,"title":["Similar cardiac remodelling after transcatheter atrial septal defect closure in children and young adults"],"prefix":"10.1136","volume":"92","author":[{"given":"G","family":"Santoro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pascotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Caputo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Cerrato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cappelli Bigazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M T","family":"Palladino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Iacono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Carrozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M G","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2005,12,9]]},"reference":[{"key":"2025092014460826000_92.7.958.1","unstructured":"Porter CJ, Feldt RH, Edward WD, et al. Atrial septal defects. In: Emmanouilides GC, Riemenschneider TA, Allen HD, et al, eds. Heart disease in infants, children and adolescents, including the fetus and young adults. 5th ed. 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