{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:59:27Z","timestamp":1785902367834,"version":"3.56.0"},"reference-count":19,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To study the effects of closure of interatrial communications associated with a right to left shunt in patients with congenital heart disease (CHD) who had a biventricular repair.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Retrospective study.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Tertiary referral centre.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> 15 patients with CHD with right to left shunt through an interatrial communication: three had repaired tetralogy of Fallot, five had repaired pulmonary atresia with intact ventricular septum, four had Ebstein\u2019s disease, and three had other CHDs. Two patients had had a stroke before closure of the interatrial communication.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Interventions:<\/jats:bold> Percutaneous atrial septal defect (n \u200a=\u200a 6) or persistent foramen ovale (n \u200a=\u200a 9) closure. All patients underwent an exercise test before and after interatrial communication closure.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Five patients were cyanotic at rest. During exercise, mean (SD) oxygen saturation diminished from 93.9 (3.8)% to 84.3 (4.8)% (p &lt; 0.05). Interatrial communication closure led to an immediate increase of oxygen saturation from 93.9 (3.8)% to 98.6 (1.6)% (p &lt; 0.05). At a median follow up of three years (range 0.5\u20135) all but one patient with a residual atrial septal defect had normal oxygen saturation at rest and during exercise. Maximum workload increased from 7.2 (1.9) to 9.0 (2.2) metabolic equivalents (p &lt; 0.001).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Percutaneous closure of interatrial communications associated with a right to left shunt allows restoration of normal oxygen saturation at rest, avoidance of desaturation during exercise, and improvement of exercise performance in patients with CHD.<\/jats:p>","DOI":"10.1136\/hrt.2005.071092","type":"journal-article","created":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T20:28:51Z","timestamp":1131049731000},"page":"827-831","source":"Crossref","is-referenced-by-count":19,"title":["Right to left shunt through interatrial septal defects in patients with congenital heart disease: results of interventional closure"],"prefix":"10.1136","volume":"92","author":[{"given":"G","family":"Agnoletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Boudjemline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Sidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2005,11,3]]},"reference":[{"key":"2025092006285683000_92.6.827.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00589-8"},{"key":"2025092006285683000_92.6.827.2","first-page":"E74","volume":"6","year":"2003","journal-title":"Heart Surg Forum"},{"key":"2025092006285683000_92.6.827.3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.echo.2003.10.014","volume":"17","year":"2004","journal-title":"J Am Soc Echocardiogr"},{"key":"2025092006285683000_92.6.827.4","first-page":"856","volume":"25","year":"2002","journal-title":"Sleep"},{"key":"2025092006285683000_92.6.827.5","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.2.221"},{"key":"2025092006285683000_92.6.827.6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2143\/AC.57.6.2005471","volume":"57","year":"2002","journal-title":"Acta Cardiol"},{"key":"2025092006285683000_92.6.827.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.17.2094"},{"key":"2025092006285683000_92.6.827.8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2.368"},{"key":"2025092006285683000_92.6.827.9","first-page":"323","volume":"3","year":"1971","journal-title":"Ann Clin Res"},{"key":"2025092006285683000_92.6.827.10","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90937-Q"},{"key":"2025092006285683000_92.6.827.11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1540-8183.2001.tb00339.x","volume":"14","year":"2001","journal-title":"J Interv Cardiol"},{"key":"2025092006285683000_92.6.827.12","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1017\/S1047951100005369","volume":"9","year":"1999","journal-title":"Cardiol Young"},{"key":"2025092006285683000_92.6.827.13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8183.2003.08005.x"},{"key":"2025092006285683000_92.6.827.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.05.044"},{"key":"2025092006285683000_92.6.827.15","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1944"},{"key":"2025092006285683000_92.6.827.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.11.037"},{"key":"2025092006285683000_92.6.827.17","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.052100"},{"key":"2025092006285683000_92.6.827.18","first-page":"186","volume":"51","year":"2000","journal-title":"Catheter Cardiovasc Interv"},{"key":"2025092006285683000_92.6.827.19","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1973.04160040010003"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2005.071092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T13:29:04Z","timestamp":1758374944000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2005.071092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,3]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2006,5,12]]},"published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1136\/hrt.2005.071092"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2005.071092","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,3]]}}}