{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:39:01Z","timestamp":1769020741936,"version":"3.49.0"},"reference-count":31,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To find out whether B-type natriuretic peptide (BNP) detects silent myocardial ischaemia in patients with type 2 diabetes, since many of these patients have silent ischaemia leading to unexpected cardiac deaths.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Prospective cross-sectional study with consecutive recruitment of patients.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Outpatient, single centre.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> 219 patients with type 2 diabetes. Patients were excluded if they had a history or evidence of cardiac failure.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Outcome measures:<\/jats:bold> BNP, echocardiography and exercise tolerance test (ETT). BNP was compared with the ETT result in all patients and specifically in those who had no apparent ischaemic heart disease (IHD).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> 121 patients had no history of IHD or cardiac failure and of these patients 85 had a clearly abnormal or normal ETT result. BNP was higher in patients with an abnormal than with a normal ETT (mean 58.2 (SD 46.3) <jats:italic>v<\/jats:italic> 24.4 (SD 15.7) pg\/ml, p &lt; 0.001). In univariate analysis BNP was an independent predictor of an abnormal ETT (p &lt; 0.001). In multivariate analysis BNP remained an independent predictor of the ETT result. BNP concentration over 20 pg\/ml predicted an abnormal ETT result with a sensitivity of 87% and specificity of 37%, and BNP over 40 pg\/ml had a sensitivity of 63% and a specificity of 81%.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> BNP is of value in predicting silent ischaemia on exercise testing in asymptomatic patients with type 2 diabetes.<\/jats:p>","DOI":"10.1136\/hrt.2005.071423","type":"journal-article","created":{"date-parts":[[2005,12,9]],"date-time":"2005-12-09T20:33:32Z","timestamp":1134160412000},"page":"916-920","source":"Crossref","is-referenced-by-count":39,"title":["B-type natriuretic peptide can detect silent myocardial ischaemia in asymptomatic type 2 diabetes"],"prefix":"10.1136","volume":"92","author":[{"given":"B S","family":"Rana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J 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