{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:16:03Z","timestamp":1761862563343,"version":"3.44.0"},"reference-count":18,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To characterise the evolution of myocardial perfusion during the first 6 months after myocardial infarction by first-pass perfusion cardiovascular magnetic resonance imaging (CMR) and determine its significance.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> Prospective cohort design.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Single-centre study in a teaching hospital in Spain.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> 40 patients with a first ST-elevation myocardial infarction, single-vessel disease and thrombolysis in myocardial infarction (TIMI) grade 3 flow (stent in 33 patients) underwent rest and low-dose dobutamine CMR 7 (SD 1) and 184 (SD 11) days after infarction. Microvascular perfusion was assessed at rest by visual assessment and quantitative analysis of first-pass perfusion CMR. Of the 640 segments, 290 segments subtended by the infarct-related artery (IRA) were focused on.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Both 1 week and 6 months after infarction, segments with normal perfusion showed more wall thickening, contractile reserve and wall thickness, and less transmural necrosis, p &lt;0.05 in all cases. Of 76 hypoperfused segments at the first week, 47 (62%) normalised perfusion at the sixth month. However, 42 segments (14% of the whole group) showed chronic abnormal perfusion; these segments showed worse CMR indices in the late phase (p&lt;0.05 in all cases).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> In patients with an open IRA, more than half of the segments with abnormal perfusion at the first week are normally perfused after six months. First-pass perfusion CMR shows that in a small percentage of segments, abnormal perfusion may become a chronic phenomenon\u2014these areas have a more severe deterioration of systolic function, wall thickness, contractile reserve and the transmural extent of necrosis.<\/jats:p>","DOI":"10.1136\/hrt.2005.077305","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T21:37:19Z","timestamp":1151444239000},"page":"1801-1807","source":"Crossref","is-referenced-by-count":35,"title":["Microvascular perfusion 1 week and 6 months after myocardial infarction by first-pass perfusion cardiovascular magnetic resonance imaging"],"prefix":"10.1136","volume":"92","author":[{"given":"V","family":"Bod\u00ed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sanchis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"L\u00f3pez-Lereu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Palau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Moratal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F 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