{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:55:08Z","timestamp":1778590508214,"version":"3.51.4"},"reference-count":40,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To determine the effect of torasemide, a loop diuretic with antialdosteronergic properties, compared with furosemide on cardiac sympathetic nerve activity in patients with congestive heart failure (CHF).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> 40 patients with non-ischaemic CHF (left ventricular ejection fraction (LVEF) &lt; 45%) were randomly assigned to torasemide (4\u20138 mg\/day; n \u200a=\u200a 20) or furosemide (20\u201340 mg\/day; n \u200a=\u200a 20). All patients were also treated with angiotensin-converting enzyme inhibitor. The delayed heart to mediastinum count (H\/M) ratio, delayed total defect score (TDS) and washout rate were determined from iodine-123 meta-iodobenzylguanidine measured before and 6 months after treatment. Left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV) and LVEF were also determined by echocardiography.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> After treatment, in patients receiving torasemide, TDS decreased from 44 (8) to 36 (8) (p &lt; 0.001), H\/M ratio increased from 1.61 (0.19) to 1.77 (0.24) (p &lt; 0.001), and washout rate decreased from 52 (12)% to 41 (14)% (p \u200a=\u200a 0.001). In addition, LVEDV decreased from 173 (22) ml to 147 (30) ml (p &lt; 0.001) and LVESV decreased from 117 (19) ml to 95(24) ml (p &lt; 0.001). Although LVEF tended to increase, the change was not significant (from 31 (7)% to 34 (7)%, NS). Conversely, these parameters did not change significantly in patients receiving furosemide. Moreover, percentage change of TDS was significantly correlated with percentage change of LVEDV (r \u200a=\u200a 0.473, p &lt; 0.05) and of LVESV (r \u200a=\u200a 0.579, p &lt; 0.01) after torasemide treatment.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> These findings indicate that torasemide treatment can ameliorate cardiac sympathetic nerve activity and left ventricular remodelling in patients with CHF.<\/jats:p>","DOI":"10.1136\/hrt.2005.079764","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T21:16:15Z","timestamp":1145394975000},"page":"1434-1440","source":"Crossref","is-referenced-by-count":77,"title":["Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart 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