{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:43:23Z","timestamp":1791193403443,"version":"4.1.0"},"reference-count":32,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                  <jats:bold>Objectives:<\/jats:bold> To evaluate potential changes of infective endocarditis (IE) in patients treated in a Finnish teaching hospital during the past 25 years.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> 326 episodes of IE in 303 patients treated during 1980\u20132004 were evaluated for clinical characteristics and their changes over time.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> The mean age of the patients increased with time (from 47.2 to 54.5 years, p \u200a=\u200a 0.003). Twenty-five (7.7%) episodes were associated with intravenous drug use (IVDU), with a significant increase of these episodes after 1996 (from 0 to 19 (20%), p &lt; 0.001). Viridans streptococci were the most common causative agents of IE during 1980\u20131994, but after that <jats:italic>Staphylococcus aureus<\/jats:italic> was the most common pathogen (p \u200a=\u200a 0.015). The proportion of IE of the aortic valve decreased during the study (from 30 (49%) to 26 (27%), whereas the proportions of mitral (11 (18%) to 33 (35%) and tricuspid valve IE (0 to 13 (14%) increased correspondingly (p \u200a=\u200a 0.001). This was mainly due to more patients with IVDU. Chronic dialysis for renal failure as an underlying condition increased over time (from 0 to 7 (7.4%), p \u200a=\u200a 0.015) but no other predisposing conditions changed. Complications such as neurological manifestations and heart failure did not change in frequency, but the incidence of lung emboli increased (from 0% to 10.5%, p &lt; 0.001); 83% of these emboli occurred in patients with IVDU. The proportion of patients requiring surgical treatment and mortality due to IE did not change.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> During these 25 years, the causative agents, affected valves and complications of IE changed to some degree. These changes were mainly attributed to the increase of IVDU-associated IE. Except for the increase in age, the clinical presentation and outcome in non-addicts remained substantially unchanged.<\/jats:p>","DOI":"10.1136\/hrt.2005.084715","type":"journal-article","created":{"date-parts":[[2006,4,27]],"date-time":"2006-04-27T20:30:50Z","timestamp":1146169850000},"page":"1457-1462","source":"Crossref","is-referenced-by-count":67,"title":["Infective endocarditis in a Finnish teaching hospital: a study on 326 episodes treated during 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