{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:39:24Z","timestamp":1792658364900,"version":"4.5.0"},"reference-count":30,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    To assess the changing profile of infective endocarditis in patients with congenital heart disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    All cases diagnosed from 1966 to 2001 (revised Duke criteria) were retrospectively reviewed and categorised in periods I (&lt; 1990) and II (\u2a7e 1990).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    153 episodes occurred, 81 in period I and 72 in period II. Mean age of affected patients was higher in period II. Non-operated ventricular septal defect, Rastelli correction and palliated cyanotic heart disease increased. Infective endocarditis in corrective surgery changed to patients with prosthetic material. Post-surgical cases decreased. Dental problems were the leading cause (period I 20%\n                    <jats:italic>v<\/jats:italic>\n                    II 33% of cases) with a large variety of pathological organisms (multiple species of\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    ). Cutaneous causative infections increased (5% to 17%) with different species of\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    . Negative blood cultures lessened (20% to 7%, p \u200a=\u200a 0.03). Streptococci were the most common causative organisms in both periods. Severe heart failure and cardiac complications lessened (20% to 4% and 31% to 18% during periods I and II, respectively). Early surgery was more frequent in period II (32%\n                    <jats:italic>v<\/jats:italic>\n                    18.5%, p \u200a=\u200a 0.02). One- and 10-year survival was 91%\n                    <jats:italic>v<\/jats:italic>\n                    97% in period I and 89%\n                    <jats:italic>v<\/jats:italic>\n                    97% in period II, respectively (NS).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Current targets include complex cyanotic disease, congenital heart disease corrected with prosthetic material and small ventricular septal defect. Postoperative cases lessened; dental and cutaneous causes increased. Survival was unchanged. Prophylactic measures targeted at dental and cutaneous sources should be emphasised.\n                  <\/jats:p>","DOI":"10.1136\/hrt.2005.085332","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T16:10:08Z","timestamp":1152115808000},"page":"1490-1495","source":"Crossref","is-referenced-by-count":134,"title":["Current patterns of infective endocarditis in congenital heart disease"],"prefix":"10.1136","volume":"92","author":[{"given":"S","family":"Di 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