{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:02:11Z","timestamp":1788919331255,"version":"build-2803163510"},"reference-count":25,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To evaluate the predictive value of brain natriuretic peptide (BNP) for assessment of cardiac risk before non-cardiac surgery.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Consecutively treated patients (947 men, 643 women) whose BNP was measured before non-cardiac surgery were studied. Clinical and ECG variables were evaluated to identify predictors of postoperative cardiac events.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Events occurred in 6% of patients: 21 cardiac deaths, 20 non-fatal myocardial infarctions, 41 episodes of pulmonary oedema and 14 patients with ventricular tachycardia. All of these patients had raised plasma BNP concentrations (best cut-off point 189 pg\/ml). The only independent predictor of postoperative events was BNP (odds ratio 34.52, 95% confidence interval (CI) 17.08 to 68.62, p &lt; 0.0001). Clinical variables of Goldman\u2019s multifactorial index identified 18% of patients in class I, 40% in class II, 24% in class III and 18% in class IV preoperatively; postoperative event rates were 2%, 3%, 7% and 14%, respectively. BNP identified 60% of patients as having zero risk (BNP 0\u2013100 pg\/ml), 22% low risk (101\u2013200 pg\/ml), 14% intermediate risk (201\u2013300 pg\/ml) and 4% high risk (&gt; 300 pg\/ml); postoperative event rates were 0%, 5%, 12% and 81%, respectively.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> In this population of patients evaluated before non-cardiac surgery, BNP is an independent predictor of postoperative cardiac events. BNP &gt; 189 pg\/ml identified patients at highest risk.<\/jats:p>","DOI":"10.1136\/hrt.2005.085530","type":"journal-article","created":{"date-parts":[[2006,5,18]],"date-time":"2006-05-18T20:58:08Z","timestamp":1147985888000},"page":"1645-1650","source":"Crossref","is-referenced-by-count":100,"title":["Assessment of cardiac risk before non-cardiac surgery: brain natriuretic peptide in 1590 patients"],"prefix":"10.1136","volume":"92","author":[{"given":"J","family":"Dernellis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Panaretou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2006,5,18]]},"reference":[{"key":"2025092100202020000_92.11.1645.1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.7326\/0003-4819-98-4-504","volume":"98","year":"1983","journal-title":"Ann Intern Med"},{"key":"2025092100202020000_92.11.1645.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199001000-00025"},{"key":"2025092100202020000_92.11.1645.3","doi-asserted-by":"publisher","DOI":"10.1067\/mva.1988.avs0080128"},{"key":"2025092100202020000_92.11.1645.4","doi-asserted-by":"crossref","first-page":"832","DOI":"10.7326\/0003-4819-103-6-832","volume":"103","year":"1985","journal-title":"Ann Intern Med"},{"key":"2025092100202020000_92.11.1645.5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-6-199609150-00001"},{"key":"2025092100202020000_92.11.1645.6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0025-6196(12)64980-5","volume":"64","year":"1989","journal-title":"Mayo Clin Proc"},{"key":"2025092100202020000_92.11.1645.7","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1977.01370120078009"},{"key":"2025092100202020000_92.11.1645.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420060100040"},{"key":"2025092100202020000_92.11.1645.9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-8-200210150-00006"},{"key":"2025092100202020000_92.11.1645.10","first-page":"121","volume":"51","year":"2003","journal-title":"Minerva Cardioangiol"},{"key":"2025092100202020000_92.11.1645.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710202971601"},{"key":"2025092100202020000_92.11.1645.12","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.11.1308"},{"key":"2025092100202020000_92.11.1645.13","unstructured":"National Committee for Clinical Laboratory Standards. Evaluation of precision performance of clinical chemistry devices: approved guideline. NCCLS Document EP5-A. Wayne, Pennsylvania: NCCLS, 1999."},{"key":"2025092100202020000_92.11.1645.14","unstructured":"National Committee for Clinical Laboratory Standards. Method comparison and bias estimation using patient samples: approved guideline. NCCLS Document EP9-A. Wayne, PA: NCCLS, 1995."},{"key":"2025092100202020000_92.11.1645.15","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4947"},{"key":"2025092100202020000_92.11.1645.16","unstructured":"Cohen MC, Eagle KA. The role of the cardiology consultant. In: Topol EJ, eds. Comprehensive cardiovascular medicine. Philadelphia: Lippincott-Raven, 1147\u201371,."},{"key":"2025092100202020000_92.11.1645.17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0735-1097(93)90670-V","volume":"21","year":"1993","journal-title":"J Am Coll Cardiol"},{"key":"2025092100202020000_92.11.1645.18","first-page":"S18","volume":"7","year":"2005","journal-title":"Clin Cornerstone"},{"key":"2025092100202020000_92.11.1645.19","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000106903.98196.B6"},{"key":"2025092100202020000_92.11.1645.20","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.031484"},{"key":"2025092100202020000_92.11.1645.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01788-0"},{"key":"2025092100202020000_92.11.1645.22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512283332607"},{"key":"2025092100202020000_92.11.1645.23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000147611.92021.2B"},{"key":"2025092100202020000_92.11.1645.24","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000103681.04726.9C"},{"key":"2025092100202020000_92.11.1645.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.6.1558"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2005.085530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T07:20:28Z","timestamp":1758439228000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2005.085530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,18]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2006,10,13]]},"published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1136\/hrt.2005.085530"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2005.085530","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,18]]}}}