{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:16:11Z","timestamp":1789694171606,"version":"4.0.1"},"reference-count":27,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2006,12]]},"abstract":"\n Objectives:<\/jats:bold>\n To test the hypotheses that (1) the central conduit arteries stiffen preferentially over the peripheral conduit arteries in patients with repaired tetralogy of Fallot (ToF); and (2) central arterial stiffening is related to aortic root dilatation.\n <\/jats:p>\n \n Design and patients:<\/jats:bold>\n Heart\u2013femoral pulse wave velocity (PWV), femoral\u2013ankle PWV, carotid augmentation index and body surface area-adjusted aortic sinotubular dimension were determined in 31 children after ToF repair and compared with those in 31 age-matched controls after left-to-right shunt repair. In addition, the PWVs and augmentation index were related to the sinotubular junction dimension.\n <\/jats:p>\n \n Settings:<\/jats:bold>\n Tertiary paediatric cardiac centre.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Compared with controls, patients had significantly greater heart\u2013femoral PWV (mean 666 (SD 151)\n v<\/jats:italic>\n 587 (81) cm\/s, p \u200a=\u200a 0.021) and carotid augmentation index (\u221214.1 (17.0)%\n v<\/jats:italic>\n \u221225.2 (14.6)%, p \u200a=\u200a 0.016), whereas the right (888 (202)\n v<\/jats:italic>\n 845 (207) cm\/s, p \u200a=\u200a 0.42) and left (918 (227)\n v<\/jats:italic>\n 851 (215) cm\/s, p \u200a=\u200a 0.25) femoral\u2013ankle PWVs were similar between the two groups. The sinotubular junction z score of patients was significantly greater than that of controls (4.7 (1.5)\n v<\/jats:italic>\n 1.1 (1.4), p < 0.001). Univariate analysis showed that the sinotubular junction z score correlated positively with heart\u2013femoral PWV (r \u200a=\u200a 0.43, p \u200a=\u200a 0.001) and carotid augmentation index (r \u200a=\u200a 0.46, p \u200a=\u200a 0.001). Multiple linear regression similarly identified heart\u2013femoral PWV (\u03b2 \u200a=\u200a 0.30, p \u200a=\u200a 0.04) and carotid augmentation index (\u03b2 \u200a=\u200a 0.31, p \u200a=\u200a 0.04) (model R\n 2<\/jats:sup>\n \u200a=\u200a 0.26) as significant determinants of sinotubular junction z score.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n The aorta stiffens in patients with repaired ToF, which may contribute to progressive dilatation of the aortic root in the long term.\n <\/jats:p>","DOI":"10.1136\/hrt.2006.091199","type":"journal-article","created":{"date-parts":[[2006,6,14]],"date-time":"2006-06-14T21:00:41Z","timestamp":1150318841000},"page":"1827-1830","source":"Crossref","is-referenced-by-count":56,"title":["Central and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: implications for aortic root dilatation"],"prefix":"10.1136","volume":"92","author":[{"given":"Y F","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2006,6,14]]},"reference":[{"key":"2025092005354456000_92.12.1827.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000028462.88597.AD"},{"key":"2025092005354456000_92.12.1827.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70232-0"},{"key":"2025092005354456000_92.12.1827.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.03.026"},{"key":"2025092005354456000_92.12.1827.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.05.037"},{"key":"2025092005354456000_92.12.1827.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.07.002"},{"key":"2025092005354456000_92.12.1827.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.3.393"},{"key":"2025092005354456000_92.12.1827.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.537928"},{"key":"2025092005354456000_92.12.1827.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80218-9"},{"key":"2025092005354456000_92.12.1827.9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.20.2677"},{"key":"2025092005354456000_92.12.1827.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.04.033"},{"key":"2025092005354456000_92.12.1827.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00965-5"},{"key":"2025092005354456000_92.12.1827.12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90619-3"},{"key":"2025092005354456000_92.12.1827.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00105-7"},{"key":"2025092005354456000_92.12.1827.14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90430-X"},{"key":"2025092005354456000_92.12.1827.15","unstructured":"Nichols WW, O\u2019Rourke MF, eds. 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