{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:23:03Z","timestamp":1776378183870,"version":"3.51.2"},"reference-count":29,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To evaluate the usefulness of cardiac iodine-123 (<jats:sup>123<\/jats:sup>I) metaiodobenzylguanidine (MIBG) imaging as a predictor of sudden death in patients with chronic heart failure (CHF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and setting:<\/jats:title>\n                  <jats:p>Prospective cohort study in a tertiary referral centre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients:<\/jats:title>\n                  <jats:p>97 outpatients with CHF with a radionuclide left ventricular ejection fraction &lt;40% (mean (SD) 29% (7.5%)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions:<\/jats:title>\n                  <jats:p>At study entry, cardiac I-123 MIBG imaging was performed. The cardiac MIBG heart-to-mediastinum ratio (H\/M) and washout rate (WR) were obtained from MIBG imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures:<\/jats:title>\n                  <jats:p>Patients were assigned to two groups based upon 27% of WR, which was the mean (2SD) control WR. 48 of 97 patients with CHF had abnormal WR (\u2a7e27%), whereas the remaining 49 patients had normal WR (&lt;27%). All the study patients were then followed up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>During the mean (SD) follow-up period of 65 (29) months, 12 (25%) patients in the abnormal WR group and 2 (4%) patients in the normal WR group died suddenly. Kaplan\u2013Meier analysis revealed that sudden death was more often observed in patients with abnormal WR than those with normal WR (p\u200a=\u200a0.001). On Cox regression analysis, MIBG WR, H\/M on the delayed image and H\/M on the early image were significantly associated with sudden death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Cardiac MIBG imaging would be useful for predicting sudden death in patients with CHF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2006.094524","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T23:31:23Z","timestamp":1173310283000},"page":"1213-1218","source":"Crossref","is-referenced-by-count":69,"title":["Prediction of sudden death in patients with mild-to-moderate chronic heart failure by using cardiac iodine-123 metaiodobenzylguanidine 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