{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:34:56Z","timestamp":1760297696316,"version":"build-2065373602"},"reference-count":29,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To investigate prognosis and prognostic factors in patients with hypertrophic cardiomyopathy (HCM) in Japan.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Design:<\/jats:bold> A nationwide epidemiological study.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Setting:<\/jats:bold> Hospitals selected randomly from among all hospitals in Japan.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients:<\/jats:bold> Clinical and epidemiological information for 2155 patients with HCM were collected in 1999.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Main outcome measures:<\/jats:bold> Patients were classified on the basis of baseline prognostic factors. Survival rates up to 5 years were calculated by Cox\u2019s proportional hazard model for 1605 patients.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> During the follow-up period, 241 deaths were recorded. The crude 5-year survival rate for the entire cohort was 86% (95% CI 84 to 88), and annual mortality ranged from 2.2% to 3.0%. A higher cardiothoracic ratio on chest <jats:italic>x<\/jats:italic> ray (HR 1.61; 95% CI 1.26 to 2.05, with 1 SD (6.2%) increase), a lower left ventricular ejection fraction (HR 1.42; 95% CI 1.20 to 1.69, with 1 SD (13%) decrease) and the presence of left bundle branch block (HR 3.14; 95% CI 1.28 to 7.71) were independently associated with a poorer prognosis, whereas the presence of apical hypertrophy at baseline (HR 0.58; 95%CI 0.36 to 0.92) predicted a better chance of survival.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> The nationwide survey of patients with hypertrophic cardiomyopathy yielded important information on its prognosis and prognostic factors. These observations afford, for the first time, a measure of risk stratification in patients with HCM in Japan.<\/jats:p>","DOI":"10.1136\/hrt.2006.095232","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T20:34:35Z","timestamp":1162586075000},"page":"711-715","source":"Crossref","is-referenced-by-count":29,"title":["Prognosis and prognostic factors in patients with hypertrophic cardiomyopathy in Japan: results from a nationwide study"],"prefix":"10.1136","volume":"93","author":[{"given":"Ali","family":"Nasermoaddeli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Matsumori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Soyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kitabatake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2006,11,3]]},"reference":[{"doi-asserted-by":"publisher","key":"2025100705154621000_93.6.711.1","DOI":"10.1001\/jama.287.10.1308"},{"doi-asserted-by":"publisher","key":"2025100705154621000_93.6.711.2","DOI":"10.1016\/S0140-6736(97)01282-8"},{"key":"2025100705154621000_93.6.711.3","first-page":"775","volume":"30","year":"1997","journal-title":"N Engl J Med"},{"doi-asserted-by":"publisher","key":"2025100705154621000_93.6.711.4","DOI":"10.1161\/01.CIR.92.7.1680"},{"key":"2025100705154621000_93.6.711.5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0033-0620(05)80036-2","volume":"36","year":"1994","journal-title":"Prog Cardiovasc Dis"},{"doi-asserted-by":"publisher","key":"2025100705154621000_93.6.711.6","DOI":"10.1016\/j.amjmed.2003.10.012"},{"doi-asserted-by":"publisher","key":"2025100705154621000_93.6.711.7","DOI":"10.1253\/circj.66.323"},{"doi-asserted-by":"publisher","key":"2025100705154621000_93.6.711.8","DOI":"10.1136\/heart.87.2.126"},{"doi-asserted-by":"publisher","key":"2025100705154621000_93.6.711.9","DOI":"10.1136\/hrt.44.6.672"},{"unstructured":"Research committee on idiopathic cardiomyopathy. 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