{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:15:48Z","timestamp":1778861748855,"version":"3.51.4"},"reference-count":5,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>\n                  <jats:bold>Objective:<\/jats:bold> To assess immediate and mid-term clinical and angiographic outcomes of the dexamethasone drug-eluting stent (D-DES) in patients with acute coronary syndrome (ACS).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Patients and methods:<\/jats:bold> A prospective, nationwide, controlled, registry. Inflammation plays a key role in ACS, and the anti-inflammatory effects of local elution of dexamethasone in unstable plaques may represent a valid therapeutic approach. All patients had ACS on admission (n\u200a=\u200a332). 81.5% of the patients had unstable angina and 18.5% had non-ST elevation myocardial infarction (MI). 47% had ST-T segment changes, 59% had troponin elevation, 77% had elevated C-reactive protein levels and 48% had intermediate\u2013high Thrombolysis in Myocardial Infarction risk score. Patients were treated according to an early invasive approach with 420 D-DES in 387 coronary lesions. Primary end point was the cumulative incidence of death, MI and ischaemia-driven target vessel revascularisation (TVR) at 6 months.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> At 30 days, 2 (0.6%) patients died, and sub-acute stent thrombosis occurred in 2 patients. At 6 months, 328 (98.8%) patients were controlled, 3 (0.9%) patients had died, 7 (2.1%) had MI and 28 (8.5%) underwent ischaemia-driven TVR. Therefore, the primary end point occurred in 11.5% of patients. At multivariate analysis, multi-vessel coronary artery disease (odds ratio (OR)\u200a=\u200a2.16, 95% CI\u200a=\u200a1.47 to 3.17, p\u200a=\u200a0.0001) and vessel diameter \u2a7d2.75 mm (OR\u200a=\u200a1.64, 95% CI\u200a=\u200a1.08 to 2.49, p\u200a=\u200a0.02) were independent predictors of 6-month clinical events. Global angiographic restenosis rate was 33.3%.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion:<\/jats:bold> This is the first large, multicentre analysis of the clinical and angiographic outcomes obtained with D-DES implanted in ACS. D-DES offers a low rate of clinical events at 6 months, but has no anti-restenosis effect.<\/jats:p>","DOI":"10.1136\/hrt.2006.098467","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T20:44:36Z","timestamp":1159389876000},"page":"598-600","source":"Crossref","is-referenced-by-count":24,"title":["Steroid-eluting stents in patients with acute coronary syndrome: the Dexamethasone Eluting Stent Italian REgistry: \n            Table 1"],"prefix":"10.1136","volume":"93","author":[{"given":"Flavio","family":"Ribichini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Tomai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Paloscia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germano","family":"Di Sciascio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Carosio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Verna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Galli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"De Cesare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimondo","family":"Pirisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Piscione","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Lanteri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Vassanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2006,9,27]]},"reference":[{"key":"2025092001061378000_93.5.598.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02336-7"},{"key":"2025092001061378000_93.5.598.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.074"},{"key":"2025092001061378000_93.5.598.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051175"},{"key":"2025092001061378000_93.5.598.4","first-page":"173","volume":"2","year":"2005","journal-title":"Eurointervention"},{"key":"2025092001061378000_93.5.598.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.061"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2006.098467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:06:33Z","timestamp":1758355593000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2006.098467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,27]]},"references-count":5,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,4,13]]},"published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1136\/hrt.2006.098467"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2006.098467","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,27]]}}}