{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:36:24Z","timestamp":1790976984110,"version":"4.1.0"},"reference-count":52,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2006,11,28]]},"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>\n                  <jats:bold>Objective and background:<\/jats:bold> To explore the possibility that increased resting heart rate (HR) is associated with a microinflammatory response. Such an association could explain, at least in part, the recently described worse cardiovascular prognosis in individuals with increased HR.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods:<\/jats:bold> Concentrations of fibrinogen and high-sensitivity C-reactive protein, as well as the absolute number of polymorphonuclear leucocytes, were analysed in a cohort of 4553 apparently healthy men and in those with atherothrombotic risk factors.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results:<\/jats:bold> Following adjustment for age and body mass index, lipid profile and cardiovascular risk factors, a significant (p&lt;0.001) difference was noted between individuals in the first quintile of HR (\u2a7d58 beats\/min) and those in the fifth quintile (\u2a7e79 beats\/min) regarding all the above-mentioned inflammatory biomarkers, the respective mean values being 7.38 and 8.11 \u03bcmol\/l, 1.12 and 1.61 mg\/l, and 4.23 and 4.74\u00d710<jats:sup>9<\/jats:sup>\/l.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions:<\/jats:bold> Resting HR is associated with a microinflammatory response in apparently healthy men and in those with atherothrombotic risk factors. Sympathetic activation might be a common factor explaining such an association. If confirmed in additional studies, this association might be a relevant target for therapeutic manipulations.<\/jats:p>","DOI":"10.1136\/hrt.2006.101949","type":"journal-article","created":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T20:14:15Z","timestamp":1169237655000},"page":"940-944","source":"Crossref","is-referenced-by-count":65,"title":["Heart rate and microinflammation in men: a relevant atherothrombotic link"],"prefix":"10.1136","volume":"93","author":[{"given":"O","family":"Rogowski","sequence":"first","affiliation":[{"name":"Department of Medicine \u201cD\u201d and Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Medicine \u201cD\u201d and Institute for Special Medical Examinations (MALRAM), Tel Aviv Sourasky Medical Center, Tel Aviv, 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