{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:24:39Z","timestamp":1781666679509,"version":"3.54.5"},"reference-count":25,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To assess pulmonary flow dynamics and right ventricular (RV) function in patients without significant anatomical narrowing of the pulmonary arteries late after the arterial switch operation (ASO) by using magnetic resonance imaging (MRI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>17 patients (mean (SD), 16.5 (3.6) years after ASO) and 17 matched healthy subjects were included. MRI was used to assess flow across the pulmonary trunk, RV systolic and diastolic function, and RV mass.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Increased peak flow velocity (&gt;1.5 m\/s) was found across the pulmonary trunk in 14 of 17 patients. Increased RV mass was found in ASO patients: 14.9 (3.4) <jats:italic>vs<\/jats:italic> 10.0 (2.6) g\/m<jats:sup>2<\/jats:sup> in normal subjects (p&lt;0.01). Delayed RV relaxation was found after ASO: mean tricuspid valve E\/A peak flow velocity ratio\u200a=\u200a1.60 (0.96) <jats:italic>vs<\/jats:italic> 1.92 (0.61) in normal subjects (p\u200a=\u200a0.03), and E-deceleration gradients\u200a=\u200a\u22121.69 (0.73) <jats:italic>vs<\/jats:italic> \u22122.66 (0.96) (p&lt;0.01). After ASO, RV mass correlated with pulmonary trunk peak flow velocity (<jats:italic>r<\/jats:italic>\u200a=\u200a0.49, p&lt;0.01) and tricuspid valve E-deceleration gradients (<jats:italic>r<\/jats:italic>\u200a=\u200a0.35, p\u200a=\u200a0.04). RV systolic function was well preserved in patients (ejection fraction\u200a=\u200a53 (7)% <jats:italic>vs<\/jats:italic> 52 (8)% in normal subjects, p\u200a=\u200a0.72).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Increased peak flow velocity in the pulmonary trunk was often observed late after ASO, even in the absence of significant pulmonary artery stenosis. Haemodynamic consequences were RV hypertrophy and RV relaxation abnormalities as early markers of disease, while systolic RV function was well preserved.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2006.109199","type":"journal-article","created":{"date-parts":[[2007,2,4]],"date-time":"2007-02-04T07:39:41Z","timestamp":1170574781000},"page":"1604-1608","source":"Crossref","is-referenced-by-count":36,"title":["Right ventricular hypertrophy and diastolic dysfunction in arterial switch patients without pulmonary artery stenosis"],"prefix":"10.1136","volume":"93","author":[{"given":"H B","family":"Grotenhuis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L J M","family":"Kroft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S G C","family":"van Elderen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J J M","family":"Westenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Doornbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Hazekamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H W","family":"Vliegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ottenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"de Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,2,3]]},"reference":[{"key":"2025092013330669000_93.12.1604.1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1148\/radiology.214.2.r00fe45467","article-title":"Arterial switch procedure for D-transposition of the great arteries: quantitative midterm evaluation of hemodynamic changes with cine MR imaging and phase-shift velocity mapping-initial experience.","volume":"214","author":"Gutberlet","year":"2000","journal-title":"Radiology"},{"key":"2025092013330669000_93.12.1604.2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.115230"},{"key":"2025092013330669000_93.12.1604.3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-726X(200006)50:2<207::AID-CCD14>3.0.CO;2-U"},{"key":"2025092013330669000_93.12.1604.4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00246-003-0483-6","article-title":"Risk factors for neo-aortic root enlargement and aortic regurgitation following arterial switch operation.","volume":"24","author":"McMahon","year":"2004","journal-title":"Pediatr Cardiol"},{"key":"2025092013330669000_93.12.1604.5","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050777"},{"key":"2025092013330669000_93.12.1604.6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/hrt.79.3.311","article-title":"Late onset pulmonary valvar stenosis after arterial switch operation for transposition of the great arteries.","volume":"79","author":"Santoro","year":"1998","journal-title":"Heart"},{"key":"2025092013330669000_93.12.1604.7","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1055\/s-2005-858122","article-title":"MRI of pulmonary arteries in follow-up after arterial-switch-operation (ASO) for transposition of great arteries (d-TGA).","volume":"177","author":"Weiss","year":"2005","journal-title":"Rofo"},{"key":"2025092013330669000_93.12.1604.8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0022-5223(19)38962-7","article-title":"Reconstruction of the pulmonary outflow tract without prosthetic conduit.","volume":"84","author":"Lecompte","year":"1982","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025092013330669000_93.12.1604.9","doi-asserted-by":"publisher","DOI":"10.1007\/BF02011950"},{"key":"2025092013330669000_93.12.1604.10","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2001.113256"},{"key":"2025092013330669000_93.12.1604.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(99)70025-8"},{"key":"2025092013330669000_93.12.1604.12","unstructured":"Meire HB Cosgrove D . 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