{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:01:19Z","timestamp":1770066079931,"version":"3.49.0"},"reference-count":42,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Because of the recently published results of the MAGIC study there is confusion as to whether administration of granulocyte-colony stimulating factor (G-CSF) after acute myocardial infarction (MI) should be regarded as a potentially harmful treatment. This meta-analysis of appropriate clinical studies is intended to show the impact of G-CSF given after MI on aggravated incidence of coronary re-stenosis or progression of coronary lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We used a fixed effects model based on the Mantel-Haenszel method to combine results from the different trials. These studies provided the basis for the current analysis comprising 106 patients of whom 62 were subjected to G-CSF treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Minimum lumen diameter (MLD) measured immediately after percutaneous coronary intervention (PCI) was similar in both groups with a diameter stenosis of 12.3% (SD 9.5%) in the G-CSF group and 10.3% (8.5%) in the control group (p\u200a=\u200a0.32). At follow-up, both MLD and percentage stenosis were not different between G-CSF-treated and control patients. Subsequently, averaged late lumen loss revealed similar results and no differences between groups (p\u200a=\u200a0.11), and neither stent thrombosis nor re-infarction in either group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The current meta-analysis of clinical reports fails to justify an elevated risk for coronary re-stenosis after PCI in acute MI or adverse events following G-CSF in the setting of MI when used after state of the art treatment in carefully conducted clinical protocols.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2006.111385","type":"journal-article","created":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T21:15:08Z","timestamp":1188422108000},"page":"610-616","source":"Crossref","is-referenced-by-count":30,"title":["Cardiovascular events and re-stenosis following administration of G-CSF in acute myocardial infarction: systematic review and meta-analysis"],"prefix":"10.1136","volume":"94","author":[{"given":"H","family":"Ince","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Valgimigli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Petzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Suarez","family":"de Lezo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Kuethe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dunkelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Biondi-Zoccai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Nienaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2007,8,29]]},"reference":[{"key":"2025092000020135000_94.5.610.1","doi-asserted-by":"crossref","first-page":"IV14","DOI":"10.1161\/circ.102.suppl_4.IV-14","article-title":"Congestive heart failure: fifty years of progress.","volume":"102","author":"Braunwald","year":"2000","journal-title":"Circulation"},{"key":"2025092000020135000_94.5.610.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68074-4"},{"key":"2025092000020135000_94.5.610.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106073442303"},{"key":"2025092000020135000_94.5.610.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012081"},{"key":"2025092000020135000_94.5.610.5","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/01.CIR.0000061910.39145.F0","article-title":"Bone marrow-derived cardiomyocytes are present in adult human heart.","volume":"107","author":"Deb","year":"2003","journal-title":"Circulation"},{"key":"2025092000020135000_94.5.610.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181177898"},{"key":"2025092000020135000_94.5.610.7","doi-asserted-by":"publisher","DOI":"10.1038\/86498"},{"key":"2025092000020135000_94.5.610.8","doi-asserted-by":"publisher","DOI":"10.1038\/35070587"},{"key":"2025092000020135000_94.5.610.9","doi-asserted-by":"publisher","DOI":"10.1038\/nature02446"},{"key":"2025092000020135000_94.5.610.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.08.014"},{"key":"2025092000020135000_94.5.610.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16626-9"},{"key":"2025092000020135000_94.5.610.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67895-6"},{"key":"2025092000020135000_94.5.610.13","doi-asserted-by":"publisher","DOI":"10.1161\/hc2301.092122"},{"key":"2025092000020135000_94.5.610.14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.541433"},{"key":"2025092000020135000_94.5.610.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15689-4"},{"key":"2025092000020135000_94.5.610.16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.168238"},{"key":"2025092000020135000_94.5.610.17","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi289"},{"key":"2025092000020135000_94.5.610.18","doi-asserted-by":"publisher","DOI":"10.1157\/13072469"},{"key":"2025092000020135000_94.5.610.19","doi-asserted-by":"crossref","unstructured":"Kuethe F Figulla HR Herzau M . 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