{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:45:07Z","timestamp":1790246707905,"version":"4.1.0"},"reference-count":26,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>The S100A8\/A9 complex is expressed in a subset of activated neutrophils and macrophages in acute inflammatory lesions associated with various diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To investigate (<jats:italic>a<\/jats:italic>) whether serum S100A8\/A9 levels are increased in patients with unstable angina (UA); and (<jats:italic>b<\/jats:italic>) whether S100A8\/A9 expression is upregulated in coronary atherosclerotic plaques of patients with UA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>Serum S100A8\/A9 levels in 39 patients with stable angina (SA) and 53 patients with UA were measured. In addition, the presence of the S100A8\/A9 complex in directional coronary atherectomy specimens was studied immunohistochemically. Cell types which stain positive for S100A8\/A9 were identified by immunodouble staining with neutrophils and macrophages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Mean (SD) serum S100A8\/A9 levels were significantly higher in patients with UA than in those with SA (3.25 (3.08) \u03bcg\/ml vs 0.77 (0.31) \u03bcg\/ml, p&lt;0.05). In patients with UA, immunodouble staining clearly showed that the S100A8\/A9 complex was expressed in infiltrated neutrophils and occasional macrophages. The S100A8\/A9-positive area was significantly higher in UA than in SA (mean (SD) 18.3 (14.2)% vs 1.3 (2.4)%, respectively, p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The S100A8\/A9 complex may be involved in the inflammatory process of coronary atherosclerotic plaques in patients with UA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2007.121640","type":"journal-article","created":{"date-parts":[[2008,2,28]],"date-time":"2008-02-28T20:55:24Z","timestamp":1204232124000},"page":"1002-1007","source":"Crossref","is-referenced-by-count":56,"title":["Increased serum levels and expression of S100A8\/A9 complex in infiltrated neutrophils in atherosclerotic plaque of unstable 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