{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:38:40Z","timestamp":1788244720267,"version":"build-2803163510"},"reference-count":24,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>To investigate the association of left ventricular outflow tract (LVOT) obstruction with blood coagulation, platelet activity and inflammatory response in patients with hypertrophic cardiomyopathy (HCM) and sinus rhythm.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and main outcome measures:<\/jats:title>\n                  <jats:p>In 42 patients with HCM with sinus rhythm, including 16 patients with resting LVOT obstruction (gradient \u2a7e30 mm Hg) and 29 age- and sex-matched controls, markers of thrombin generation (thrombin\u2013antithrombin complex (TAT), prothrombin fragment 1+2 (F1+2)), platelet activation (soluble CD40 ligand (sCD40L), \u03b2-thromboglobulin (\u03b2-TG), P-selectin) and inflammation (C-reactive protein (CRP), interleukin (IL)6, tumour necrosis factor-\u03b1 (TNF\u03b1)) were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Thrombin, platelet and inflammatory markers were higher in the entire HCM group than in controls (p&lt;0.005 for all compared parameters). Compared with non-obstructive HCM, obstructive HCM was associated with increased thrombin formation (TAT, F1+2), platelet activation (sCD40L, \u03b2-TG, P-selectin) and both CRP and IL6 levels. Only the level of TNF\u03b1 was similar in both forms of HCM. In contrast, a comparison of non-obstructive HCM with controls showed that all these variables (except for P-selectin) were similar; P-selectin was higher in non-obstructive HCM. The LVOT gradient correlated positively with all the raised blood markers (<jats:italic>r<\/jats:italic> from 0.39 to 0.73; p&lt;0.05), except for TNF\u03b1. In multiple regression analysis models, the LVOT gradient was the only independent predictor of TAT (<jats:italic>R<\/jats:italic>\n                     <jats:sup>2<\/jats:sup>\u200a=\u200a0.61; p&lt;0.001), sCD40L (<jats:italic>R<\/jats:italic>\n                     <jats:sup>2<\/jats:sup>\u200a=\u200a0.59; p&lt;0.001), F1+2 (<jats:italic>R<\/jats:italic>\n                     <jats:sup>2<\/jats:sup>\u200a=\u200a0.55; p\u200a=\u200a0.002), P-selectin (<jats:italic>R<\/jats:italic>\n                     <jats:sup>2<\/jats:sup>\u200a=\u200a0.49; p\u200a=\u200a0.004) and \u03b2-TG (<jats:italic>R<\/jats:italic>\n                     <jats:sup>2<\/jats:sup>\u200a=\u200a0.38; p\u200a=\u200a0.005) in patients with HCM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>LVOT obstruction is independently associated with enhanced thrombin generation and platelet activity in patients with HCM with sinus rhythm.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2007.126896","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T20:12:44Z","timestamp":1192219964000},"page":"e21-e21","source":"Crossref","is-referenced-by-count":41,"title":["Obstructive hypertrophic cardiomyopathy is associated with enhanced thrombin generation and platelet activation"],"prefix":"10.1136","volume":"94","author":[{"given":"P P","family":"Dimitrow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Undas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Tracz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Dubiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,10,8]]},"reference":[{"key":"2025101714095405000_94.6.e21.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.8.858"},{"key":"2025101714095405000_94.6.e21.2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0735-1097(01)01727-2","article-title":"Clinical profile of stroke in 900 patients with hypertrophic cardiomyopathy.","volume":"39","author":"Maron","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2025101714095405000_94.6.e21.3","doi-asserted-by":"publisher","DOI":"10.1161\/hc4601.097997"},{"key":"2025101714095405000_94.6.e21.4","doi-asserted-by":"crossref","unstructured":"Cecchi F Olivotto I Maron BJ . Other modes of disability or death including stroke, and treatment strategies, in hypertrophic cardiomyopathy. In: Maron B J , ed. Diagnosis and management of hypertrophic cardiomyopathy. Oxforf: Blackwell Futura, 2004:121\u201331.","DOI":"10.1002\/9780470987469.ch7"},{"key":"2025101714095405000_94.6.e21.5","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00049-A"},{"key":"2025101714095405000_94.6.e21.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05753.x"},{"key":"2025101714095405000_94.6.e21.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.078"},{"key":"2025101714095405000_94.6.e21.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"2025101714095405000_94.6.e21.9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl041"},{"key":"2025101714095405000_94.6.e21.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00048-X"},{"key":"2025101714095405000_94.6.e21.11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/01.ATV.0000154579.11213.da","article-title":"Exercise and the prothrombotic state: a paradox of cardiovascular prevention or an enhanced prothrombotic state?","volume":"25","author":"Thrall","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2025101714095405000_94.6.e21.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.841"},{"key":"2025101714095405000_94.6.e21.13","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.031161"},{"key":"2025101714095405000_94.6.e21.14","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.644682"},{"key":"2025101714095405000_94.6.e21.15","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(89)90545-7"},{"key":"2025101714095405000_94.6.e21.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.023"},{"key":"2025101714095405000_94.6.e21.17","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.46.231"},{"key":"2025101714095405000_94.6.e21.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(84)80141-1"},{"key":"2025101714095405000_94.6.e21.19","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1161\/01.CIR.87.5.1570","article-title":"Morphological determinants of echocardiographic patterns of mitral valve systolic anterior motion in obstructive hypertrophic cardiomyopathy.","volume":"87","author":"Klues","year":"1993","journal-title":"Circulation"},{"key":"2025101714095405000_94.6.e21.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04546-0"},{"key":"2025101714095405000_94.6.e21.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00830-5"},{"key":"2025101714095405000_94.6.e21.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01172-4"},{"key":"2025101714095405000_94.6.e21.23","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.068577"},{"key":"2025101714095405000_94.6.e21.24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025050"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2007.126896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T21:10:02Z","timestamp":1760735402000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2007.126896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,8]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,5,14]]},"published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1136\/hrt.2007.126896"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2007.126896","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,8]]}}}