{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:28:42Z","timestamp":1781659722112,"version":"3.54.5"},"reference-count":18,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In recent years percutaneous, transcatheter closure of atrial septal defects (ASD) or patent foramen ovale (PFO) was introduced into clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the functional effects on heart valves caused by an interatrial closure device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results:<\/jats:title>\n                    <jats:p>Between 2001 and 2006, 240 consecutive patients underwent percutaneous closure of an ASD or a PFO. Heart valve functions were defined by transoesophageal echocardiography before implantation and 3, 6 and 12 months after defect closure. A successful implantation procedure was performed in 98% of patients. Sufficient closure without residual shunt was achieved in 89% of patients with ASD and in 92% of patients with PFO. An overall major complication rate of 0.8% was apparent during the observation time (mean (SD) 27 (15) months). Long-term follow-up disclosed newly developed or worsened aortic valve regurgitation (AR) in 9% of patients with ASD and in 10% of patients with PFO. A potential cause for developing AR may be overgrowth of the device by tissue, leading to changes in interatrial septal geometry and traction on the root of the non-coronary aortic cusp.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>AR occurred in 9% of patients with closed ASD and in 10% of patients with closed PFO. Indication for closure should consider this potential complication despite an otherwise safe interventional procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/hrt.2007.132662","type":"journal-article","created":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T20:35:28Z","timestamp":1197318928000},"page":"844-847","source":"Crossref","is-referenced-by-count":56,"title":["Incidence of aortic valve regurgitation and outcome after percutaneous closure of atrial septal defects and patent foramen ovale"],"prefix":"10.1136","volume":"94","author":[{"given":"S P","family":"Schoen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Boscheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M U","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Fuhrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Kappert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R H","family":"Strasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2007,12,10]]},"reference":[{"key":"2025092005063673000_94.7.844.1","unstructured":"Moss AJ Adams FH . Heart disease in infants, children, and adolescents including the fetus and young. 5th ed. Baltimore, Md: Williams & Wilkins, 1995:60\u201370, 689\u2013701."},{"key":"2025092005063673000_94.7.844.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.6.2259"},{"key":"2025092005063673000_94.7.844.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000029924.90823.E0"},{"key":"2025092005063673000_94.7.844.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01427-9"},{"key":"2025092005063673000_94.7.844.5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.052258"},{"key":"2025092005063673000_94.7.844.6","first-page":"117","article-title":"Transcatheter closure of secundum atrial septal defects with complex anatomy.","volume":"16","author":"Pedra","year":"2004","journal-title":"J Invasive Cardiol"},{"key":"2025092005063673000_94.7.844.7","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.2.199"},{"key":"2025092005063673000_94.7.844.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000019069.32964.0E"},{"key":"2025092005063673000_94.7.844.9","doi-asserted-by":"crossref","unstructured":"Martin F Sanchez PL Doherty E . Percutaneous transcatheter closure of patent foramen ovale in patients with paradoxical embolism. Circulation 200227;106:1121\u20136.","DOI":"10.1161\/01.CIR.0000027819.19722.EE"},{"key":"2025092005063673000_94.7.844.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01904-6"},{"key":"2025092005063673000_94.7.844.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.176857"},{"key":"2025092005063673000_94.7.844.12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0025-6196(12)60540-0","article-title":"Doppler echocardiography: theory, instrumentation, technique, and application.","volume":"60","author":"Nishimura","year":"1985","journal-title":"Mayo Clin Proc"},{"key":"2025092005063673000_94.7.844.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00039-4"},{"key":"2025092005063673000_94.7.844.14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1540-8183.2001.tb00711.x","article-title":"Catheter closure of atrial septal defects and patent foramen ovale in patients with an atrial septal aneurysm using different devices.","volume":"14","author":"Krumsdorf","year":"2001","journal-title":"J Interv Cardiol"},{"key":"2025092005063673000_94.7.844.15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2006.00125.x"},{"key":"2025092005063673000_94.7.844.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00304-0"},{"key":"2025092005063673000_94.7.844.17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1540-8183.2001.tb00709.x","article-title":"Transcatheter closure of atrial septal defects in children and adults using the Amplatzer septal occluder.","volume":"14","author":"Omeish","year":"2001","journal-title":"J Interv Cardiol"},{"key":"2025092005063673000_94.7.844.18","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-007-0502-3"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2007.132662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T12:06:44Z","timestamp":1758370004000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2007.132662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,10]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2008,6,13]]},"published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1136\/hrt.2007.132662"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2007.132662","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1158105.618206","asserted-by":"object"}]},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,10]]}}}