{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:23:47Z","timestamp":1765758227851,"version":"3.44.0"},"reference-count":29,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background:<\/jats:title>\n                  <jats:p>Early risk stratification is important in the management of patients with acute coronary syndromes (ACS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To develop a rapidly available risk stratification tool for use in all ACS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and methods:<\/jats:title>\n                  <jats:p>Application of modern data mining and machine learning algorithms to a derivation cohort of 7520 ACS patients included in the AMIS (Acute Myocardial Infarction in Switzerland)-Plus registry between 2001 and 2005; prospective model testing in two validation cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The most accurate prediction of in-hospital mortality was achieved with the \u201cAveraged One-Dependence Estimators\u201d (AODE) algorithm, with input of seven variables available at first patient contact: age, Killip class, systolic blood pressure, heart rate, pre-hospital cardiopulmonary resuscitation, history of heart failure, history of cerebrovascular disease. The c-statistic for the derivation cohort (0.875) was essentially maintained in important subgroups, and calibration over five risk categories, ranging from &lt;1% to &gt;30% predicted mortality, was accurate. Results were validated prospectively against an independent AMIS-Plus cohort (n\u200a=\u200a2854, c-statistic 0.868) and the Krakow-Region ACS Registry (n\u200a=\u200a2635, c-statistic 0.842). The AMIS model significantly outperformed established \u201cpoint-of-care\u201d risk-prediction tools in both validation cohorts. In comparison to a logistic regression-based model, the AODE-based model proved to be more robust when tested on the Krakow validation cohort (c-statistic 0.842 vs 0.746). Accuracy of the AMIS model prediction was maintained at 12-month follow-up in an independent cohort (n\u200a=\u200a1972, c-statistic 0.877).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The AMIS model is a reproducibly accurate point-of-care risk stratification tool for the complete range of ACS, based on variables available at first patient contact.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2008.145904","type":"journal-article","created":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T20:25:39Z","timestamp":1228854339000},"page":"662-668","source":"Crossref","is-referenced-by-count":27,"title":["Simple point-of-care risk stratification in acute coronary syndromes: the AMIS model"],"prefix":"10.1136","volume":"95","author":[{"given":"D J","family":"Kurz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Radovanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Erne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Siudak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Bertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2008,12,9]]},"reference":[{"key":"2025092021404144000_95.8.662.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm161"},{"key":"2025092021404144000_95.8.662.2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.24.6.745"},{"key":"2025092021404144000_95.8.662.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)91035-6"},{"key":"2025092021404144000_95.8.662.4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)90918-6"},{"key":"2025092021404144000_95.8.662.5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530410036030"},{"key":"2025092021404144000_95.8.662.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.6.1659"},{"key":"2025092021404144000_95.8.662.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.17.2031"},{"key":"2025092021404144000_95.8.662.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.7.835"},{"key":"2025092021404144000_95.8.662.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06649-1"},{"key":"2025092021404144000_95.8.662.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.6.599"},{"key":"2025092021404144000_95.8.662.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.22.2557"},{"key":"2025092021404144000_95.8.662.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.041"},{"key":"2025092021404144000_95.8.662.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.11.036"},{"key":"2025092021404144000_95.8.662.14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1356"},{"key":"2025092021404144000_95.8.662.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02468-2"},{"key":"2025092021404144000_95.8.662.16","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.19.2345"},{"key":"2025092021404144000_95.8.662.17","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.037689"},{"key":"2025092021404144000_95.8.662.18","first-page":"1053","article-title":"Management of myocardial infarction with ST-segment elevation in district hospitals without catheterisation laboratory\u2014Acute Coronary Syndromes Registry of Malopolska 2002\u20132003.","volume":"64","author":"Dudek","year":"2006","journal-title":"Kardiol Pol"},{"key":"2025092021404144000_95.8.662.19","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32812cb91c"},{"key":"2025092021404144000_95.8.662.20","unstructured":"Witten IH Frank E . 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