{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:39:49Z","timestamp":1760297989683,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>We compared the degree of systemic inflammation and its relation to the angiographic outcomes after drug-eluting stent (DES) implantations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>We implanted a single DES in 79 stable angina patients (50 men; 60.4 (9.5) years of age; sirolimus-eluting stent (SES), n\u200a=\u200a38; paclitaxel-eluting stent (PES), n\u200a=\u200a41). The high-sensitivity C-reactive protein (hs-CRP) and interleukin 6 (IL-6) levels were determined before and at 24 hours, 72 hours, and 4 weeks after the percutaneous coronary intervention (PCI). An angiography and intravascular ultrasound (IVUS) were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>The hs-CRP and IL-6 levels at baseline did not differ between the two groups. The hs-CRP increased significantly from baseline at 24 hours and 72 hours after the PCI in both groups and there was a significant increase in the IL-6 level at 24 hours after the PCI in both groups. However, there was no significant difference between the two groups in any of the hs-CRP or IL-6 measurements. At follow-up, the late lumen loss was significantly higher in the PES group than in the SES group (0.57 (0.56) mm vs 0.28 (0.58) mm, respectively, p\u200a=\u200a0.020). The neointimal hyperplasia (NIH) volume in the PES group was significantly higher than that in the SES group (23.1 (22.7) vs 3.8 (7.1) mm<jats:sup>3<\/jats:sup>, respectively, p\u200a=\u200a0.000). The percentage luminal volume reduction was higher in the PES group than in the SES group (18.9 vs 3.9%, p\u200a=\u200a0.002). The absolute values or change in the inflammatory markers did not correlate with the NIH or stent volume reduction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Our study showed that the benefits obtained from the SES, which reduce neointimal proliferation, are not probably mediated by the attenuation of the systemic inflammatory markers hs-CRP or IL-6.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2008.153114","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T20:25:21Z","timestamp":1220559921000},"page":"970-975","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of inflammatory markers and angiographic outcomes after implantation of sirolimus and paclitaxel-eluting stents"],"prefix":"10.1136","volume":"95","author":[{"given":"W 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