{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:56:47Z","timestamp":1793123807630,"version":"4.5.0"},"reference-count":19,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To analyse the potential benefit of restoration of pulmonary valvar competence in patients with severe pulmonary regurgitation (PR) and pulmonary hypertension (PH) associated with congenital heart disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>Retrospective study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting:<\/jats:title>\n                  <jats:p>Tertiary paediatric and adult congenital heart cardiac centre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions:<\/jats:title>\n                  <jats:p>Percutaneous pulmonary valve implantation (PPVI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients:<\/jats:title>\n                  <jats:p>All patients who underwent PPVI for treatment of PR in the presence of PH (mean PAP &gt;25 mm Hg).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Seven patients with severe PH as a result of congenital heart disease and severe PR underwent PPVI. The valve implantation procedure was feasible and uncomplicated in all seven cases, successfully abolishing PR. There was a significant increase in diastolic (15.4 (7.3) to 34.0 (8.5) mm Hg; p\u200a=\u200a0.007) and mean (29.7 (8.1) to 41.3 (12.9) mm Hg; p\u200a=\u200a0.034) pulmonary artery pressures, and an improvement in NYHA functional class (from median IV to median III; p&lt;0.008). Peripheral oxygen saturations rose from 85.9% (11.0%) to 91.7% (8.3%) (p\u200a=\u200a0.036). Right ventricular (RV) volumes decreased (from 157.0 (44.7) to 140.3 (53.3) ml\/m<jats:sup>2<\/jats:sup>), while effective RV stroke volume increased (from 23.4 (9.3) to 41.0 (11.6) ml\/m<jats:sup>2<\/jats:sup>). During a median follow-up of 20.3 months (range 1.3\u201347.5), valvar competence was well maintained despite near systemic pulmonary pressures. None of the valved stents were explanted during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion:<\/jats:title>\n                  <jats:p>Trans-catheter treatment of PR in patients with PH is well tolerated and leads to clinical and haemodynamic improvement, most probably caused by a combination of increased pulmonary perfusion pressures and RV efficiency.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2008.153379","type":"journal-article","created":{"date-parts":[[2009,3,30]],"date-time":"2009-03-30T10:45:52Z","timestamp":1238409952000},"page":"646-650","source":"Crossref","is-referenced-by-count":24,"title":["Immediate clinical and haemodynamic benefits of restoration of pulmonary valvar competence in patients with pulmonary hypertension"],"prefix":"10.1136","volume":"95","author":[{"given":"P","family":"Lurz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Nordmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Coats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bonhoeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Schulze-Neick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,3,27]]},"reference":[{"key":"2025100706175429000_95.8.646.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-2-216"},{"key":"2025100706175429000_95.8.646.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-5-343"},{"key":"2025100706175429000_95.8.646.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.5.1037"},{"key":"2025100706175429000_95.8.646.4","first-page":"I38","article-title":"Second natural history study of congenital heart defects. 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