{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:06:44Z","timestamp":1780376804631,"version":"3.54.1"},"reference-count":30,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To identify patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) with a low likelihood of any adverse in-hospital event.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, setting and patients:<\/jats:title>\n                  <jats:p>Data were analysed from 24 097 patients with NSTEMI or unstable angina included in the Global Registry of Acute Coronary Events (January 2001 to September 2007).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures:<\/jats:title>\n                  <jats:p>In-hospital events were myocardial infarction, arrhythmia, congestive heart failure or shock, major bleeding, stroke or death. Two-thirds of the patients were randomly chosen for model development and the remainder for model validation. Multiple logistic regression identified predictors of freedom from an in-hospital event, and a Freedom-from-Event score was developed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of the 16 127 patients in the model development group, 19.1% experienced an in-hospital adverse event. Fifteen factors independently predicted freedom from an adverse event: younger age; lower Killip class; unstable angina presentation; no hypotension; no ST deviation; no cardiac arrest at presentation; normal creatinine; decreased pulse rate; no hospital transfer; no history of diabetes, heart failure, peripheral arterial disease, or atrial fibrillation; prehospital use of statins, and no chronic warfarin. In the validation group, 18.6% experienced an adverse event. The model discriminated well between patients experiencing an in-hospital event and those who did not in both derivation and validation groups (c-statistic\u200a=\u200a0.77 in both). Patients in the three lowest risk deciles had a very low in-hospital mortality (&lt;0.5%) and an uncomplicated clinical course (&gt;93% event-free in hospital). The model also predicted freedom from postdischarge events (death, myocardial infarction, stroke; c-statistic\u200a=\u200a0.77).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>The GRACE Freedom-from-Event score can predict the in-hospital course of NSTE-ACS, and identifies up to 30% of the admitted population at low risk of death or any adverse in-hospital event.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2008.153387","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T20:25:30Z","timestamp":1235679930000},"page":"888-894","source":"Crossref","is-referenced-by-count":69,"title":["Predicting freedom from clinical events in non-ST-elevation acute coronary syndromes: the Global Registry of Acute Coronary Events"],"prefix":"10.1136","volume":"95","author":[{"given":"D","family":"Brieger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K A A","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"FitzGerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K A","family":"Eagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Budaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1","family":"Avezum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C B","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"F A","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ph G","family":"Steg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,2,25]]},"reference":[{"key":"2025092007121338000_95.11.888.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02489-X"},{"key":"2025092007121338000_95.11.888.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109691.16944.DA"},{"key":"2025092007121338000_95.11.888.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00485-8"},{"key":"2025092007121338000_95.11.888.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.06.001"},{"key":"2025092007121338000_95.11.888.5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.694273"},{"key":"2025092007121338000_95.11.888.6","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3385"},{"key":"2025092007121338000_95.11.888.7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.7.835"},{"key":"2025092007121338000_95.11.888.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.22.2557"},{"key":"2025092007121338000_95.11.888.9","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.19.2345"},{"key":"2025092007121338000_95.11.888.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00977-3"},{"key":"2025092007121338000_95.11.888.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.512806"},{"key":"2025092007121338000_95.11.888.12","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.031369"},{"key":"2025092007121338000_95.11.888.13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0735-1097(02)03019-X","article-title":"The thrombolysis in myocardial infarction risk score in unstable angina\/non-ST-segment elevation myocardial infarction.","volume":"41","author":"Sabatine","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"2025092007121338000_95.11.888.14","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl133"},{"key":"2025092007121338000_95.11.888.15","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2005.06.031"},{"key":"2025092007121338000_95.11.888.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2005.09.010"},{"key":"2025092007121338000_95.11.888.17","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.112404"},{"key":"2025092007121338000_95.11.888.18","unstructured":"Harrell FEJ . 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Incidence and prognosis of ventricular tachycardia and ventricular fibrillation after non-ST elevation acute coronary syndromes: insights from the Global Registry of Acute Coronary Events. 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