{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:21:02Z","timestamp":1769124062504,"version":"3.49.0"},"reference-count":30,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine the mid-term and long-term outcomes in patients with obstructive hypertrophic cardiomyopathy (HCM) submitted to pacing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective, observational study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Single, non-referral centre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and intervention<\/jats:title>\n                  <jats:p>Fifty patients (62\u00b111\u2005years) with HCM refractory to medical treatment, all in New York Heart Association (NYHA) class III or IV, and with a rest gradient &gt;50\u2005mm\u2002Hg underwent a dual-chamber pacemaker implantation. Patients were followed-up for up to 10 years (mean 5.0\u00b12.9, range 0.6\u201310.1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the first year of follow-up, rest gradients decreased (baseline 86\u00b129\u2005mm\u2002Hg; 3\u2005months 55\u00b137; l\u2005year 41\u00b126; p=0.0001). NYHA class improved, as well as exercise tolerance (baseline 281\u00b1112 m; 3 months 334\u00b1106 m; 1 year 348\u00b178 m; p&lt;0.0001). The physical and mental components of the quality of life instrument SF-36 also improved. Left ventricular wall thickness remained unchanged, while ejection fraction decreased (baseline 76\u00b110%; 3 months 74\u00b18%; 1 year 66\u00b113%; p=0.002). During the long-term follow-up, an additional reduction in obstruction was found (final rest gradient 28\u00b124\u2005mm\u2002Hg, p&lt;0.02). Those patients who did not improve to NYHA class I or II and continued to have obstruction were given other treatments (six, alcohol ablation; three, surgical myectomy).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Pacing in HCM results in a significant reduction in obstruction, improvement of symptoms and exercise capacity that is progressive and may be achieved after a long period of time. In this series, only 18% of cases needed a more aggressive treatment to relieve residual obstruction and obtain a satisfactory symptomatic status. In conclusion, these results emphasise the need for new controlled studies of pacing with a longer follow-up.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2008.158915","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T20:13:27Z","timestamp":1243628007000},"page":"352-356","source":"Crossref","is-referenced-by-count":58,"title":["Late benefits of dual-chamber pacing in obstructive hypertrophic cardiomyopathy: a 10-year follow-up study"],"prefix":"10.1136","volume":"96","author":[{"given":"Enrique","family":"Galve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Sambola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Salda\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Quispe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Candell-Riera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,5,28]]},"reference":[{"key":"2025092000213252000_96.5.352.1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.154435"},{"key":"2025092000213252000_96.5.352.2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.126003"},{"key":"2025092000213252000_96.5.352.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"2025092000213252000_96.5.352.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.04.063"},{"key":"2025092000213252000_96.5.352.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.013"},{"key":"2025092000213252000_96.5.352.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.02.090"},{"key":"2025092000213252000_96.5.352.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.3.467"},{"key":"2025092000213252000_96.5.352.8","first-page":"I191","article-title":"Results of operation for hypertrophic obstructive cardiomyopathy in children and adults less than 40 years of age","volume":"80","author":"Mohr","year":"1989","journal-title":"Circulation"},{"key":"2025092000213252000_96.5.352.9","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3285"},{"key":"2025092000213252000_96.5.352.10","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1520"},{"key":"2025092000213252000_96.5.352.11","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015435"},{"key":"2025092000213252000_96.5.352.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.22.2927"},{"key":"2025092000213252000_96.5.352.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00173-4"},{"key":"2025092000213252000_96.5.352.14","first-page":"562","article-title":"Treatment of hypertrophic obstructive cardiomyopathy with dual chamber pacing. 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