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Consequently, besides its other positive clinical outcomes, there has been much hope for ultrafiltration therapy to play a protective role against negative effects of diuretics in patients with decompensated heart failure. However, the potential biological advantage has not been confirmed by clinical studies; currently available data from recent clinical trials have so far failed to demonstrate such expected positive results possibly due to counterbalance of the potential negative effects and other not well-known mechanisms. This paper briefly reviews the relevant pathophysiological mechanisms as well as existing evidence in this area and emphasises on the need for further studies specifically designed to explore the impact of ultrafiltration on kidney function in patients with decompensated heart failure.<\/jats:p>","DOI":"10.1136\/hrt.2008.160218","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T20:13:58Z","timestamp":1236197638000},"page":"1047-1051","source":"Crossref","is-referenced-by-count":16,"title":["Ultrafiltration for decompensated heart failure: renal implications: Table 1"],"prefix":"10.1136","volume":"95","author":[{"given":"A","family":"Kazory","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2009,3,3]]},"reference":[{"key":"2025092001503570000_95.13.1047.1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.jacc.2004.07.040","article-title":"Renal insufficiency as an independent predictor of mortality among women with heart failure.","volume":"44","author":"Bibbins-Domingo","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2025092001503570000_95.13.1047.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.072"},{"key":"2025092001503570000_95.13.1047.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000135121.81744.75"},{"key":"2025092001503570000_95.13.1047.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.580506"},{"key":"2025092001503570000_95.13.1047.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.11.084"},{"key":"2025092001503570000_95.13.1047.6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.2.203"},{"key":"2025092001503570000_95.13.1047.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010641"},{"key":"2025092001503570000_95.13.1047.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.02.007"},{"key":"2025092001503570000_95.13.1047.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.05.010"},{"key":"2025092001503570000_95.13.1047.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.07.031"},{"key":"2025092001503570000_95.13.1047.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00705-0"},{"key":"2025092001503570000_95.13.1047.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70113-4"},{"key":"2025092001503570000_95.13.1047.13","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000296270.41256.5C"},{"key":"2025092001503570000_95.13.1047.14","doi-asserted-by":"publisher","DOI":"10.1054\/jcaf.2002.125289"},{"key":"2025092001503570000_95.13.1047.15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.5.628"},{"key":"2025092001503570000_95.13.1047.16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.742270"},{"key":"2025092001503570000_95.13.1047.17","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.068296"},{"key":"2025092001503570000_95.13.1047.18","doi-asserted-by":"publisher","DOI":"10.1159\/000047397"},{"key":"2025092001503570000_95.13.1047.19","first-page":"F900","article-title":"Expression of the thiazide-sensitive Na\u2013Cl cotransporter in rat and human kidney.","volume":"269","author":"Obermuller","year":"1995","journal-title":"Am J Physiol"},{"key":"2025092001503570000_95.13.1047.20","unstructured":"Packer M Kessler PD Gottlieb SS . 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