{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:15:02Z","timestamp":1790072102956,"version":"4.0.1"},"reference-count":30,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To determine whether the influence of sleep apnoea (SA) on the risk of death differs in patients with ischaemic and in those with non-ischaemic heart failure (HF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>Prospective observational study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients:<\/jats:title>\n                  <jats:p>Consecutive patients with HF with left ventricular ejection fraction \u2a7d45% newly referred to the HF clinic between 1 September 1997 and 1 December 2004.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures:<\/jats:title>\n                  <jats:p>Patients underwent sleep studies and were divided into those with moderate to severe SA (apnoea\u2013hypopnoea index \u2a7e15\/h of sleep) and those with mild to no SA (apnoea\u2013hypopnoea index &lt;15\/h of sleep). They were followed up for a mean of 32 months to determine all-cause mortality rate.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Of 193 patients, 34 (18%) died. In the ischaemic group, mortality risk adjusted for confounding factors was significantly higher in those with SA than in those without it (18.9 vs 4.6 deaths\/100 patient-years, hazards ratio (HR)\u200a=\u200a3.03, 95% CI 1.04 to 8.84, p\u200a=\u200a0.043). In contrast, in the non-ischaemic HF group, there was no difference in adjusted mortality risk between those with, and those without, SA (3.9 vs 4.0 deaths\/100 patient-years, p\u200a=\u200a0.929).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>In patients with HF, the presence of SA is independently associated with an increased risk of death in those with ischaemic, but not in those with non-ischaemic, aetiology. These findings suggest that patients with ischaemic cardiomyopathy are more susceptible to the adverse haemodynamic, autonomic and inflammatory consequences of SA than are those with non-ischaemic cardiomyopathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2008.160952","type":"journal-article","created":{"date-parts":[[2009,1,8]],"date-time":"2009-01-08T20:55:29Z","timestamp":1231448129000},"page":"819-824","source":"Crossref","is-referenced-by-count":100,"title":["Relationship between sleep apnoea and mortality in patients with ischaemic heart failure"],"prefix":"10.1136","volume":"95","author":[{"given":"D","family":"Yumino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J S","family":"Floras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G 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