{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:04:30Z","timestamp":1789992270329,"version":"4.0.1"},"reference-count":24,"publisher":"BMJ","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2009,10,20]]},"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This prospective study aimed to determine to what extent clinical symptoms and neurohumoral activation are improved in patients with severe aortic valve stenosis after transcatheter aortic valve implantation (TAVI) with the CoreValve prosthesis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From June 2008 to June 2009 consecutive patients with symptomatic severe aortic valve stenosis (area&lt;1\u2005cm<jats:sup>2<\/jats:sup>), age\u226575\u2005years with a logistic EuroSCORE \u226515% or age&gt;60\u2005years plus additional specified risk factors were evaluated for TAVI. Examinations of study patients were performed before and 30\u2005days after TAVI and comprised assessment of quality of life (Minnesota living with heart failure questionnaire, [MLHFQ]) 6-minute walk test, measurement of B-type natriuretic peptide and echocardiography. Aortic valve prosthesis was inserted retrograde using a femoral arterial or a subclavian artery approach.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In 44 consecutive patients (mean age 79.1\u00b17\u2005years, 50% women, mean left ventricular ejection fraction 55.8\u00b18.5%) TAVI was successfully performed. Follow-up 30\u2005days after TAVI showed a significantly improved quality of life (baseline 44\u00b119.1 vs 28\u00b117.5 MLHFQ Score, p&lt;0.001) and an enhanced distance in the 6-minute walk test (baseline 204\u00b1103 vs 266\u00b1123\u2005m, p&lt;0.001). B-type natriuretic peptide levels were reduced (baseline 725\u00b1837 vs 423\u00b1320 pg\/ml, p=0.005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our preliminary results show a significant clinical benefit and a reduction of neurohormonal activation in patients with severe and symptomatic aortic valve stenosis early after TAVI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2009.180661","type":"journal-article","created":{"date-parts":[[2009,11,2]],"date-time":"2009-11-02T20:18:36Z","timestamp":1257193116000},"page":"1102-1106","source":"Crossref","is-referenced-by-count":88,"title":["Short-term effects of transcatheter aortic valve implantation on neurohormonal activation, quality of life and 6-minute walk test in severe and symptomatic aortic stenosis"],"prefix":"10.1136","volume":"96","author":[{"given":"Michael","family":"Gotzmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hehen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfried","family":"Germing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lindstaedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydan","family":"Yazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Laczkovics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Mumme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"M\u00fcgge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Bojara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,11,1]]},"reference":[{"key":"2025101711302114000_96.14.1102.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.18.1949"},{"key":"2025101711302114000_96.14.1102.2","unstructured":"Otto CM Bonow RO . Aortic stenosis. In: Libby P Bonow RO Mann DL Zipes DP , eds. Braunwald's heart disease. 8th edn. Philadelphia: WB Saunders, 2008, pp. 1626\u20138."},{"key":"2025101711302114000_96.14.1102.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000060533.79248.0C"},{"key":"2025101711302114000_96.14.1102.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.002"},{"key":"2025101711302114000_96.14.1102.5","first-page":"1252","article-title":"Working Group on Valvular Heart Disease. Recommendations on the management of the asymptomatic patient with valvular heart disease","volume":"23","author":"Lung","year":"2002","journal-title":"Eur Heart J"},{"key":"2025101711302114000_96.14.1102.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.026"},{"key":"2025101711302114000_96.14.1102.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.698258"},{"key":"2025101711302114000_96.14.1102.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.04.047"},{"key":"2025101711302114000_96.14.1102.9","first-page":"198","article-title":"Patients' self-assessment of their congestive heart failure, II: content, reliability, and validity of a new measure","volume":"3","author":"Rector","year":"1987","journal-title":"Heart Fail"},{"key":"2025101711302114000_96.14.1102.10","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90488-M"},{"key":"2025101711302114000_96.14.1102.11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"2025101711302114000_96.14.1102.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.10.081"},{"key":"2025101711302114000_96.14.1102.13","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00106-2"},{"key":"2025101711302114000_96.14.1102.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.11.059"},{"key":"2025101711302114000_96.14.1102.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"2025101711302114000_96.14.1102.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-009-0750-5"},{"key":"2025101711302114000_96.14.1102.17","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"2025101711302114000_96.14.1102.18","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.118468"},{"key":"2025101711302114000_96.14.1102.19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi162"},{"key":"2025101711302114000_96.14.1102.20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.85.3.387"},{"key":"2025101711302114000_96.14.1102.21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp171"},{"key":"2025101711302114000_96.14.1102.22","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837453"},{"key":"2025101711302114000_96.14.1102.23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000126825.50903.18"},{"key":"2025101711302114000_96.14.1102.24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi236"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2009.180661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T18:30:28Z","timestamp":1760725828000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2009.180661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,1]]},"references-count":24,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2010,7,7]]},"published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1136\/hrt.2009.180661"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2009.180661","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,1]]}}}