{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:59:56Z","timestamp":1791910796133,"version":"4.3.4"},"reference-count":28,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective:<\/jats:title>\n                  <jats:p>To investigate whether simple and non-invasive measurement of N-terminal pro-brain natriuretic peptide (NT-proBNP) and\/or C-reactive protein (CRP) can predict perioperative major cardiovascular event (PMCE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design:<\/jats:title>\n                  <jats:p>Prospective, single-centre, cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting:<\/jats:title>\n                  <jats:p>A 1900-bed tertiary-care university hospital in Seoul, Korea<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and patients:<\/jats:title>\n                  <jats:p>The predictive power of NT-proBNP, CRP and Revised Cardiac Risk Index (RCRI) for the risk of PMCE (myocardial infarction, pulmonary oedema or cardiovascular death) were evaluated from a prospective cohort of 2054 elective major non-cardiac surgery patients. Optimal cut-off values were derived from receiver operating characteristic curve (ROC) analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measurement:<\/jats:title>\n                  <jats:p>PMCE (myocardial infarction, pulmonary oedema or cardiovascular death) within postoperative 30 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>PMCE developed in a total of 290 patients (14.1%). Each increasing quartile of NT-proBNP or CRP level was associated with a greater risk of PMCE after adjustment for traditional clinical risk factors. The relative risk (RR) of highest versus lowest quartile was 5.2 for NT-proBNP (p&lt;0.001) and 3.7 for CRP (p&lt;0.001). Both NT-proBNP (cut-off \u200a=\u200a301 ng\/l) and CRP (cut-off \u200a=\u200a3.4 mg\/l) predicted PMCE better than RCRI (cut-off \u200a=\u200a2) by ROC analysis (p&lt;0.001). Moreover, the predictive power of RCRI (adjusted RR \u200a=\u200a1.5) could be improved significantly by addition of CRP and NT-proBNP to RCRI (adjusted RR 4.6) (p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>High preoperative NT-proBNP or CRP is a strong and independent predictor of perioperative major cardiovascular event in non-cardiac surgery. The predictive power of current clinical risk evaluation system would be strengthened by these biomarkers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2009.181388","type":"journal-article","created":{"date-parts":[[2009,10,27]],"date-time":"2009-10-27T20:13:09Z","timestamp":1256674389000},"page":"56-62","source":"Crossref","is-referenced-by-count":124,"title":["Preoperative NT-proBNP and CRP predict perioperative major cardiovascular events in non-cardiac surgery"],"prefix":"10.1136","volume":"96","author":[{"given":"J-H","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D K","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-B","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-Y","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-C","family":"Gwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D-K","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S H","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J K","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E-S","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2009,10,26]]},"reference":[{"key":"2025092004090379000_96.1.56.1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050011"},{"key":"2025092004090379000_96.1.56.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710202971601"},{"key":"2025092004090379000_96.1.56.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1986.00360230047007"},{"key":"2025092004090379000_96.1.56.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.10.1043"},{"key":"2025092004090379000_96.1.56.5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.898"},{"key":"2025092004090379000_96.1.56.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.059"},{"key":"2025092004090379000_96.1.56.7","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2003.09.004"},{"key":"2025092004090379000_96.1.56.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.003"},{"key":"2025092004090379000_96.1.56.9","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.13.1609"},{"key":"2025092004090379000_96.1.56.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707064"},{"key":"2025092004090379000_96.1.56.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67786-0"},{"key":"2025092004090379000_96.1.56.12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.22.2866"},{"key":"2025092004090379000_96.1.56.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.07.058"},{"key":"2025092004090379000_96.1.56.14","first-page":"ITC1","article-title":"In the clinic. Preoperative evaluation.","volume":"151","author":"Laine","year":"2009","journal-title":"Ann Intern Med"},{"key":"2025092004090379000_96.1.56.15","doi-asserted-by":"publisher","DOI":"10.1373\/49.3.433"},{"key":"2025092004090379000_96.1.56.16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.19.1690"},{"key":"2025092004090379000_96.1.56.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.08.003"},{"key":"2025092004090379000_96.1.56.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.005"},{"key":"2025092004090379000_96.1.56.19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm521"},{"key":"2025092004090379000_96.1.56.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.07.057"},{"key":"2025092004090379000_96.1.56.21","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.11.1323"},{"key":"2025092004090379000_96.1.56.22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.8.980"},{"key":"2025092004090379000_96.1.56.23","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.832576"},{"key":"2025092004090379000_96.1.56.24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm620"},{"key":"2025092004090379000_96.1.56.25","doi-asserted-by":"crossref","unstructured":"Owens CD Ridker PM Belkin M . Elevated C-reactive protein levels are associated with postoperative events in patients undergoing lower extremity vein bypass surgery. J Vasc Surg 2007;45:2\u20139; discussion 9.","DOI":"10.1016\/j.jvs.2006.08.048"},{"key":"2025092004090379000_96.1.56.26","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50118"},{"key":"2025092004090379000_96.1.56.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60601-7"},{"key":"2025092004090379000_96.1.56.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61560-3"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2009.181388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T11:09:11Z","timestamp":1758366551000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2009.181388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,26]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,12,17]]},"published-print":{"date-parts":[[2010,1,1]]}},"alternative-id":["10.1136\/hrt.2009.181388"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2009.181388","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,26]]}}}