{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:07:41Z","timestamp":1791252461848,"version":"4.1.0"},"reference-count":28,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,3,2]]},"published-print":{"date-parts":[[2011,2,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The traditionally accepted mechanism for ventricular adaptation to obesity suggests that cavity dilatation in response to increased blood volume and elevated filling pressure results in ventricular hypertrophy as a compensatory mechanism. Our hypothesis was that, instead, initiation of ventricular hypertrophy in obesity may be explained by changes in hormonal milieu and not by cavity dilatation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Research design and methods<\/jats:title>\n                  <jats:p>88 female subjects without identifiable cardiovascular risk factors, covering a wide range of body mass indices (BMI), from normal (21.2\u00b11.6\u2005kg\/m<jats:sup>2<\/jats:sup>) to severely obese (45.0\u00b14.6\u2005kg\/m<jats:sup>2<\/jats:sup>), underwent cardiovascular MRI to determine left ventricular (LV) and right ventricular (RV) mass and volumes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>BMI correlated positively with LV and RV mass and end-diastolic volumes (EDV). However overweight is associated with a significant LV and RV hypertrophy (LV: 78\u00b111\u2005g vs 103\u00b116\u2005g, p&lt;0.01; RV: 26\u00b17\u2005g vs 40\u00b111\u2005g, p&lt;0.01) was observed in the absence of differences in LV and RV volumes (LV: EDV 119\u00b115 vs 121\u00b121\u2005ml, p&gt;0.99, RV: 131\u00b117 vs 130\u00b124\u2005ml; p&gt;0.99). Furthermore, significant increases of serum leptin occurred at this pre-obese stage (15.6\u00b119 vs 36.5\u00b122\u2005ng\/ml; p=0.013).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In a cohort of healthy female subjects with a wide range of BMIs, ventricular hypertrophy occurs without associated cavity dilatation in overweight individuals, while in manifest obesity, both cavity dilatation and ventricular hypertrophy occur. Elevated leptin levels may have a role in this effect on ventricular mass.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2009.185009","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T20:35:55Z","timestamp":1274214955000},"page":"203-208","source":"Crossref","is-referenced-by-count":62,"title":["Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity"],"prefix":"10.1136","volume":"97","author":[{"given":"Oliver J","family":"Rider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen E","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane M","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed 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