{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:32:22Z","timestamp":1787506342199,"version":"build-2736575974"},"reference-count":23,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Amplatzer duct occluder (ADO) has been used with success to close large patent ductus arteriosus (PDA), but some problems exist especially with hypertensive PDAs, such as incomplete closure, haemolysis, left pulmonary artery stenosis, obstruction of the descending aorta and progressive pulmonary vascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We analysed a group of 168 patients with isolated PDA and pulmonary artery systolic pressure (PSAP) \u226550\u2005mm\u2002Hg. Mean age was 10.3 \u00b1 14.3\u2005years (median 3.9), PDA diameter was 6.4 \u00b1 2.9\u2005mm (median 5.9), PASP was 63.5 \u00b1 16.2\u2005mm\u2002Hg (median 60), Qp\/Qs was 2.7 \u00b1 1.2 (median 2.5), total pulmonary resistance index (PRI) was 3.69 \u00b1 2.15 (median 3.35) and vascular PRI was 2.73 \u00b1 1.72 (median 2.37). We used ADOs in 145 (86.3%) cases, Amplatzer muscular ventricular septal defect occluders (AMVSDO) in 18 (10.7%), Amplatzer septal occluders (ASO) in three (1.8%) and the Gianturco-Grifka device in two (1.2%) cases. Device diameter was 106.3% \u00b1 51% higher than PDA diameter. PASP decreased after occlusion to 42.5 \u00b1 13.3\u2005mm\u2002Hg (p&lt;0.00001). Immediately after closure, no or trivial shunt was present in 123 (74.5%) cases. Immediate complications were device embolisation in five (3%) cases and descending aortic obstruction in one case. The overall success rate was 98.2%. Follow-up in 145 (86.3%) cases for 37.1 \u00b1 24\u2005months (median 34.1) showed further decrease of the PASP to 30.1 \u00b1 7.7\u2005mm\u2002Hg (p&lt;0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Percutaneous treatment of hypertensive PDA is safe and effective. ADO works well for most cases, but sometimes other devices (MVSDO or ASO) have to be used. When cases are selected adequately, pulmonary pressures decrease immediately and continue to fall with time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/hrt.2009.185025","type":"journal-article","created":{"date-parts":[[2010,3,31]],"date-time":"2010-03-31T22:41:00Z","timestamp":1270075260000},"page":"625-629","source":"Crossref","is-referenced-by-count":33,"title":["Percutaneous closure of hypertensive ductus arteriosus"],"prefix":"10.1136","volume":"96","author":[{"given":"Carlos","family":"Zabal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Garc\u00eda-Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Buend\u00eda-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Calder\u00f3n-Colmenero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Pati\u00f1o-Bahena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Juanico-Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fause","family":"Attie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,3,31]]},"reference":[{"key":"2025101801315276000_96.8.625.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90514-Y"},{"key":"2025101801315276000_96.8.625.2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90765-X"},{"key":"2025101801315276000_96.8.625.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(96)90603-7"},{"key":"2025101801315276000_96.8.625.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02023.x"},{"key":"2025101801315276000_96.8.625.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(97)70158-3"},{"key":"2025101801315276000_96.8.625.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00058-3"},{"key":"2025101801315276000_96.8.625.7","first-page":"121","article-title":"Transcatheter occlusion of PDA using detachable nitinol coil (Abstract)","volume-title":"Abstracts. The fourth Paediatric Interventional Cardiac Symposium (PICS-IV)","volume":"51","author":"Le","year":"2000"},{"key":"2025101801315276000_96.8.625.8","doi-asserted-by":"publisher","DOI":"10.1002\/1522-726X(200009)51:1<50::AID-CCD11>3.0.CO;2-6"},{"key":"2025101801315276000_96.8.625.9","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1247"},{"key":"2025101801315276000_96.8.625.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01451-X"},{"key":"2025101801315276000_96.8.625.11","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1540-8183.2001.tb00741.x","article-title":"The Duct-Occlud Device: Design, Clinical Results, and Future Directions","volume":"14","author":"Moore","year":"2001","journal-title":"J Interv Cardiol"},{"key":"2025101801315276000_96.8.625.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.074"},{"key":"2025101801315276000_96.8.625.13","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.3.5.865"},{"key":"2025101801315276000_96.8.625.14","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20039"},{"key":"2025101801315276000_96.8.625.15","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10090"},{"key":"2025101801315276000_96.8.625.16","first-page":"121","article-title":"Transcatheter devices for large patent ductus arteriosus","volume":"8","author":"Arora","year":"2004","journal-title":"Cardiology Today"},{"key":"2025101801315276000_96.8.625.17","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.101444"},{"key":"2025101801315276000_96.8.625.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00013-8"},{"key":"2025101801315276000_96.8.625.19","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.3.260"},{"key":"2025101801315276000_96.8.625.20","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2006.091215"},{"key":"2025101801315276000_96.8.625.21","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-007-9174-z"},{"key":"2025101801315276000_96.8.625.22","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/01.CIR.58.6.1094","article-title":"Magnification Pulmonary Wedge Angiography in the Evaluation of Children with Congenital Heart Disease and Pulmonary Hypertension","volume":"58","author":"Nihill","year":"1978","journal-title":"Circulation"},{"key":"2025101801315276000_96.8.625.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.03.080"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2009.185025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:31:59Z","timestamp":1760776319000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2009.185025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,31]]},"references-count":23,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,3,31]]},"published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1136\/hrt.2009.185025"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2009.185025","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,31]]}}}