{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:31:33Z","timestamp":1788294693843,"version":"build-2803163510"},"reference-count":49,"publisher":"BMJ","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,4,6]]},"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The concept of non-atherosclerotic coronary artery pathology in sudden cardiac death (SCD) has not been given the attention it deserves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine the incidence of non-atherosclerotic coronary artery pathology in SCD and raise awareness among cardiologists and pathologists alike.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective non-case-controlled analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Cardiac pathology centre at the National Heart and Lung Institute and Royal Brompton Hospital.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Subjects<\/jats:title>\n                  <jats:p>Between 1994 and 2008, the hearts of 1647 people undergoing SCD were referred for pathological assessment to ascertain the precise aetiology of SCD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty (3.0%) of the 1647 cases of SCD were associated with non-atherosclerotic coronary pathology (31 male subjects (62%) and 19 female subjects (38%, age range (8\u2005weeks\u201371\u2005years)). Twenty four of the 50 cases had anomalous coronary arteries (48%); eight cases had coronary artery dissection (16%); six cases had coronary artery vasculitis (12%); six cases had coronary artery spasm (12%); three cases had idiopathic arterial calcification of infancy (6%); two cases had fibromuscular dysplasia (4%) and one case had a benign tumour occluding the left coronary ostium (2%). Only 20 of the 50 patients (40%) were documented to have experienced cardiac symptoms such as syncope, chest pain on exertion or breathlessness before their SCD. Twelve of the patients (24%) died during or immediately after physical exertion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Non-atherosclerotic coronary disease is associated with sudden death in all age groups, particularly younger, male patients. Cardiologists need to be aware of these entities and investigate any patient who has cardiac symptoms especially with exertion.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2009.185157","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T20:58:26Z","timestamp":1275080306000},"page":"1119-1125","source":"Crossref","is-referenced-by-count":138,"title":["Non-atherosclerotic coronary artery disease associated with sudden cardiac death"],"prefix":"10.1136","volume":"96","author":[{"given":"Sharleen F","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary N","family":"Sheppard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,5,28]]},"reference":[{"key":"2025100704575461000_96.14.1119.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2007.11.002"},{"key":"2025100704575461000_96.14.1119.2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1161\/01.CIR.91.6.1749","article-title":"Risk factors for sudden cardiac death in middle-aged British men","volume":"91","author":"Wannamethee","year":"1995","journal-title":"Circulation"},{"key":"2025100704575461000_96.14.1119.3","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2001.2824"},{"key":"2025100704575461000_96.14.1119.4","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg038"},{"key":"2025100704575461000_96.14.1119.5","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.168369"},{"key":"2025100704575461000_96.14.1119.6","first-page":"465","article-title":"The healing of myocardial infarcts in man","volume":"5","author":"Baroldi","year":"1975","journal-title":"G Ital Cardiol"},{"key":"2025100704575461000_96.14.1119.7","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90343-1"},{"key":"2025100704575461000_96.14.1119.8","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.062034"},{"key":"2025100704575461000_96.14.1119.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.035"},{"key":"2025100704575461000_96.14.1119.10","doi-asserted-by":"publisher","DOI":"10.1148\/122.1.47"},{"key":"2025100704575461000_96.14.1119.11","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810210110"},{"key":"2025100704575461000_96.14.1119.12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.14.5.800"},{"key":"2025100704575461000_96.14.1119.13","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.6.649"},{"key":"2025100704575461000_96.14.1119.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00254-1"},{"key":"2025100704575461000_96.14.1119.15","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000238397.50341.4a"},{"key":"2025100704575461000_96.14.1119.16","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.045518"},{"key":"2025100704575461000_96.14.1119.17","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.50.6.1231"},{"key":"2025100704575461000_96.14.1119.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016175.49835.57"},{"key":"2025100704575461000_96.14.1119.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00566-0"},{"key":"2025100704575461000_96.14.1119.20","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90019-J"},{"key":"2025100704575461000_96.14.1119.21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(91)90251-F"},{"key":"2025100704575461000_96.14.1119.22","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4244\/EIJV4I5A107","article-title":"Prevalence and characteristics of major and minor coronary artery anomalies in an adult population assessed by computed tomography coronary angiography","volume":"4","author":"Rodr\u00edguez-Granillo","year":"2009","journal-title":"EuroIntervention"},{"key":"2025100704575461000_96.14.1119.23","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-11-200412070-00005"},{"key":"2025100704575461000_96.14.1119.24","first-page":"941","article-title":"Major anomalies of coronary arterial origin seen in adulthood","volume":"111","author":"Roberts","year":"1986","journal-title":"J Am Cardiol"},{"key":"2025100704575461000_96.14.1119.25","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90277-5"},{"key":"2025100704575461000_96.14.1119.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341607"},{"key":"2025100704575461000_96.14.1119.27","first-page":"271","article-title":"Coronary artery anomalies\u2014current clinical issues: definitions, classification, incidence, clinical relevance, and treatment guidelines","volume":"29","author":"Angelini","year":"2002","journal-title":"Tex Heart Inst J"},{"key":"2025100704575461000_96.14.1119.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.052"},{"key":"2025100704575461000_96.14.1119.29","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1.89"},{"key":"2025100704575461000_96.14.1119.30","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1997)10:5<297::AID-CA1>3.0.CO;2-O"},{"key":"2025100704575461000_96.14.1119.31","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(96)01121-9"},{"key":"2025100704575461000_96.14.1119.32","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951102000100"},{"key":"2025100704575461000_96.14.1119.33","first-page":"354","article-title":"Congenital atresia of the left coronary ostium and hypoplasia of the left main coronary artery","volume":"99","author":"Byrum","year":"1980","journal-title":"J Am Cardiol"},{"key":"2025100704575461000_96.14.1119.34","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000038420.14867.7A"},{"key":"2025100704575461000_96.14.1119.35","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.66.5.364"},{"key":"2025100704575461000_96.14.1119.36","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1661"},{"key":"2025100704575461000_96.14.1119.37","doi-asserted-by":"publisher","DOI":"10.1177\/000331970405500216"},{"key":"2025100704575461000_96.14.1119.38","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(95)90312-7"},{"key":"2025100704575461000_96.14.1119.39","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035360"},{"key":"2025100704575461000_96.14.1119.40","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.75.6_Suppl_2.45"},{"key":"2025100704575461000_96.14.1119.41","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.1047"},{"key":"2025100704575461000_96.14.1119.42","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.038364"},{"key":"2025100704575461000_96.14.1119.43","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199811)18:11<1186::AID-PD423>3.0.CO;2-5"},{"key":"2025100704575461000_96.14.1119.44","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-005-0645-0"},{"key":"2025100704575461000_96.14.1119.45","first-page":"99","article-title":"Fibromuscular dysplasia and acute myocardial infarction: evidence for a unique clinical and angiographic pattern","volume":"18","author":"Huizar","year":"2006","journal-title":"J Invasive Cardiol"},{"key":"2025100704575461000_96.14.1119.46","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0272-6386(98)70096-4","article-title":"Bilateral fibromuscular dysplasia in identical twins","volume":"32","author":"Bigazzi","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"2025100704575461000_96.14.1119.47","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.HYP.14.5.472","article-title":"Etiologic factors in renovascular fibromuscular dysplasia A case-control study","volume":"14","author":"Sang","year":"1989","journal-title":"Hypertension"},{"key":"2025100704575461000_96.14.1119.48","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-199612000-00001"},{"key":"2025100704575461000_96.14.1119.49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/MCA.0b013e3282f528f1","article-title":"Imaging of coronary artery anomalies: the role of multidetector computed tomography","volume":"19","author":"Kacmaz","year":"2008","journal-title":"Coron Artery Dis"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.2009.185157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:58:03Z","timestamp":1759838283000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.2009.185157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,28]]},"references-count":49,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2010,7,7]]},"published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1136\/hrt.2009.185157"],"URL":"https:\/\/doi.org\/10.1136\/hrt.2009.185157","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,28]]}}}