{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:28:12Z","timestamp":1760783292360,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,3,30]]},"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Although the Maze procedure is regarded as the most effective way to restore sinus rhythm in patients with chronic atrial fibrillation (AF), it remains unclear whether this procedure offers long-term clinical benefits in patients undergoing mechanical valve replacement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>Between 1999 and 2007, 402 patients with AF-associated mitral valve (MV) disease underwent MV replacement with a mechanical prosthesis. Of these patients, 159 underwent valve replacement plus the Maze procedure, whereas 243 received valve replacement alone. The composite end points of cardiac death and cardiac-related morbidities were compared in these two groups using the inverse-probability-of-treatment-weighted method. At a median follow-up time of 63.1\u2005months (range 0.2\u2013123.9\u2005months), patients who had undergone the Maze procedure were at significantly lower risk of thromboembolic events (hazard ratio (HR)=0.26, 95% confidence interval (CI) 0.07 to 0.95; p=0.041) and were at comparable risk of death (HR=0.96, 95% CI 0.44 to 2.07; p=0.907) and cardiac death (HR=1.26, 95% CI 0.53 to 3.01; p=0.598) compared with patients who underwent MV replacement alone. The composite risk of death or major events was lower in the Maze procedure group (HR=0.64, 95% CI 0.38 to 1.08; p=0.093).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Compared with MV replacement alone, the addition of the Maze procedure was associated with a reduction in thromboembolic complications and better long-term event-free survival in patients with AF undergoing mechanical MV replacement. Prospective randomised data are necessary to confirm the findings of this study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2010.192435","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T06:03:34Z","timestamp":1278482614000},"page":"1126-1131","source":"Crossref","is-referenced-by-count":20,"title":["Mitral valve replacement with or without a concomitant Maze procedure in patients with atrial fibrillation"],"prefix":"10.1136","volume":"96","author":[{"given":"Joon Bum","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Ho","family":"Ju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Cheol","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Ho","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Hyun","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk Jung","family":"Choo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taek Yeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2010,7,7]]},"reference":[{"key":"2025092000023749000_96.14.1126.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470140088029"},{"key":"2025092000023749000_96.14.1126.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.10.037"},{"key":"2025092000023749000_96.14.1126.3","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.124392"},{"issue":"(5 Pt 2)","key":"2025092000023749000_96.14.1126.4","first-page":"II285","article-title":"Restoration of atrial function after the Maze procedure for patients with atrial fibrillation. Assessment by Doppler echocardiography","volume":"90","author":"Feinberg","year":"1994","journal-title":"Circulation"},{"key":"2025092000023749000_96.14.1126.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.07.028"},{"key":"2025092000023749000_96.14.1126.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03176-9"},{"key":"2025092000023749000_96.14.1126.7","first-page":"165","article-title":"Eight-year experience of combined valve repair for mitral regurgitation and Maze procedure","volume":"11","author":"Kobayashi","year":"2002","journal-title":"J Heart Valve Dis"},{"key":"2025092000023749000_96.14.1126.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.03.004"},{"key":"2025092000023749000_96.14.1126.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)00550-6"},{"key":"2025092000023749000_96.14.1126.10","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum120"},{"key":"2025092000023749000_96.14.1126.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.03.014"},{"key":"2025092000023749000_96.14.1126.12","doi-asserted-by":"crossref","unstructured":"Kim JB Kim HJ Moon DH . 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