{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:53:51Z","timestamp":1791042831047,"version":"4.1.0"},"reference-count":35,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,11,23]]},"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Cardiac disease related to transfusional iron overload is the leading cause of death in patients with \u03b2-thalassaemia major. Early myocardial iron deposition predates decreased left ventricular dysfunction and currently is best assessed by cardiac magnetic resonance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Echocardiographic speckle tracking-derived myocardial mechanics were compared with cardiac MRI T2 star (T2*) calculations in 45 chronically transfused patients with \u03b2-thalassaemia major or Diamond\u2013Blackfan anaemia (26 retrospectively and an additional 19 for validation). Two groups were studied: patients with presumed cardiac iron overload and interventricular T2* value \u226420\u2005ms (low T2*) and patients with &gt;20\u2005ms (normal T2*). They were compared with a normal control group of 18 age- and gender-matched patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with low T2* had a uniform decrease in longitudinal and circumferential strain compared with normal controls (\u221216\u00b13% vs \u221220\u00b13% and \u221220\u00b14% vs \u221223\u00b15%, respectively; p&lt;0.0005). Peak twist and peak apical rotation were lower in patients with low T2* than in those with normal T2* or normal control patients. Conversely, no significant difference was observed between patients with normal T2* and controls. There was a strong and direct logarithmic correlation between average global longitudinal strain and T2* values (r=\u22120.68, p=0.0007). Using a cut-off of \u2264\u221217%, global longitudinal strain predicted a T2* value of &lt;20\u2005ms with a sensitivity of 76% and a specificity of 88%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Myocardial mechanics offers a simple alternative to cardiac MRI for assessing significant myocardial iron deposition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2010.192641","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T04:33:02Z","timestamp":1296793982000},"page":"388-393","source":"Crossref","is-referenced-by-count":36,"title":["Quantification of myocardial iron deposition by two-dimensional speckle tracking in patients with \u03b2-thalassaemia major and Blackfan\u2013Diamond anaemia"],"prefix":"10.1136","volume":"97","author":[{"given":"P","family":"Garceau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E 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