{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:46:20Z","timestamp":1790610380497,"version":"4.1.0"},"reference-count":31,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,6,15]]},"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In patients with aortic stenosis (AS) left ventricular (LV) myocardial growth may exceed individual needs to compensate LV haemodynamic load leading to inappropriately high LV mass (iLVM), a condition at high risk of adverse cardiovascular events. The prognostic impact of iLVM was determined in 218 patients with asymptomatic severe AS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>iLVM was recognised when the measured LV mass exceeded 10% of the expected value predicted from height, sex and stroke work (prognostic cut-off assessed by a specific ROC analysis). For assessment of outcome, the endpoint was defined as death from all causes, aortic valve replacement or hospital admission for non-fatal myocardial infarction and\/or congestive heart failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At the end of follow-up (22+13 months) complete clinical data were available for 209 participants (mean age 75+11 years). A clinical event occurred in 81 of 121 patients (67%) with iLVM and in 26 of 88 patients (30%) with appropriate LV mass (aLVM) (p&lt;0.001). Event-free survival in patients with aLVM and iLVM was 78% vs 56% at 1-year, 68% vs 29% at 3-year and 56% vs 10% at 5-year follow-up, respectively (all p&lt;0.01). Cox analysis identified iLVM as a strong predictor of adverse outcome (Exp \u03b2 3.08; CI 1.65 to 5.73) independent of diabetes, transaortic valve peak gradient and extent of valvular calcification. Among patients with LV hypertrophy, those with iLVM had a risk of adverse events 4.5-fold higher than counterparts with aLVM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>iLVM is common in patients with asymptomatic severe AS and is associated with an increased rate of cardiovascular events independent of other prognostic covariates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2010.192997","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T23:00:04Z","timestamp":1282172404000},"page":"301-307","source":"Crossref","is-referenced-by-count":281,"title":["Prognostic effect of inappropriately high left ventricular mass in asymptomatic severe aortic stenosis"],"prefix":"10.1136","volume":"97","author":[{"given":"Giovanni","family":"Cioffi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pompilio","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Vizzardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tarantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Cramariuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gerdts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"de Simone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,8,18]]},"reference":[{"key":"2025091922301886000_97.4.301.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90437-5"},{"key":"2025091922301886000_97.4.301.2","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/01.CIR.86.3.926","article-title":"Abnormal left ventricular intracavitary flow acceleration in patients undergoing aortic valve replacement for aortic stenosis: a marker for high postoperative morbidity and mortality","volume":"86","author":"Aurigemma","year":"1992","journal-title":"Circulation"},{"key":"2025091922301886000_97.4.301.3","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90595-R"},{"key":"2025091922301886000_97.4.301.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.075"},{"key":"2025091922301886000_97.4.301.5","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32831cec98"},{"key":"2025091922301886000_97.4.301.6","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200101000-00016"},{"key":"2025091922301886000_97.4.301.7","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/HJH.0b013e32803fb60c","article-title":"Excessive increase in left ventricular mass identifies hypertensive subjects with clustered geometric and functional abnormalities","volume":"25","author":"Chinali","year":"2007","journal-title":"J Hypertens"},{"key":"2025091922301886000_97.4.301.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000034740.99323.8A"},{"key":"2025091922301886000_97.4.301.9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm605"},{"key":"2025091922301886000_97.4.301.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.03.036"},{"key":"2025091922301886000_97.4.301.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.190748"},{"key":"2025091922301886000_97.4.301.12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"2025091922301886000_97.4.301.13","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00540-7"},{"key":"2025091922301886000_97.4.301.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"2025091922301886000_97.4.301.15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90491-4"},{"key":"2025091922301886000_97.4.301.16","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90390-5"},{"key":"2025091922301886000_97.4.301.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.03.069"},{"key":"2025091922301886000_97.4.301.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.7.765"},{"key":"2025091922301886000_97.4.301.19","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/01.CIR.35.5.868","article-title":"Percentage of left ventricular stroke work loss. 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