{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:19:28Z","timestamp":1790518768590,"version":"4.1.0"},"reference-count":25,"publisher":"BMJ","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,6,30]]},"published-print":{"date-parts":[[2010,12,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To confirm the effects of short-term exposure to ozone (O<jats:sub>3<\/jats:sub>) on ischaemic heart and cerebrovascular disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Daily levels of urban O<jats:sub>3<\/jats:sub> pollution, the incidence of first-ever, recurrent, fatal and non-fatal ischaemic cerebrovascular events (ICVE) and myocardial infarction (MI) were correlated using a case-crossover design. The authors analysed 1574 ICVE and 913 MI that occurred in Dijon, France (150\u2008000 inhabitants) from 2001 to 2007. Sulfur dioxide (SO<jats:sub>2<\/jats:sub>), nitrogen dioxide (NO<jats:sub>2<\/jats:sub>), carbon monoxide (CO) and particulate matter with an aerodiameter of \u226410\u2005\u03bcg\/m<jats:sup>3<\/jats:sup> (PM<jats:sub>10<\/jats:sub>) were used to create bi-pollutant models. Using the adjusted OR, the effects of O<jats:sub>3<\/jats:sub> exposure were calculated for every 10\u2005\u03bcg\/m<jats:sup>3<\/jats:sup> increase in pollutants in multivariate logistic models adjusted for temperature, humidity, flu outbreaks and holidays.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The authors found a significant association between exposure to O<jats:sub>3<\/jats:sub> and recurrent ICVE with a 3-day lag (OR=1.115; 95% CI 1.027 to 1.209). The direction and magnitude of the association between exposure to O<jats:sub>3<\/jats:sub> and recurrent MI were similar but not statistically significant. For incident events, the authors detected only a non-significant association for ICVE with a 2-day lag (OR=1.041; 95% CI 0.996 to 1.089). In the subgroup analysis for ICVE, the authors observed an increased association with cardiovascular risk factors (OR=1.523; 95% CI 1.149 to 2.018). For MI, the authors found an association with O<jats:sub>3<\/jats:sub> when hypercholesterolaemia was present (OR=1.111; 95% CI 1.020 to 1.211), and the association became stronger with the number of cardiovascular risk factors. The authors found a marked dose\u2013response relationship.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Recurrent ICVE and MI could be triggered by short-term exposure to even low levels of O<jats:sub>3<\/jats:sub>, especially among subjects with severe vascular risk factors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2010.200337","type":"journal-article","created":{"date-parts":[[2010,8,11]],"date-time":"2010-08-11T21:10:04Z","timestamp":1281561004000},"page":"1990-1996","source":"Crossref","is-referenced-by-count":65,"title":["Evidence of the role of short-term exposure to ozone on ischaemic cerebral and cardiac events: the Dijon Vascular Project (DIVA)"],"prefix":"10.1136","volume":"96","author":[{"given":"Jean-Bernard","family":"Henrotin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Zeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Lorgis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Cottin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Giroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"B\u00e9jot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,8,11]]},"reference":[{"key":"2025092000561079000_96.24.1990.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11274-8"},{"key":"2025092000561079000_96.24.1990.2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14d21.x"},{"key":"2025092000561079000_96.24.1990.3","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000165817.40152.85"},{"key":"2025092000561079000_96.24.1990.4","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000165821.90114.7f"},{"key":"2025092000561079000_96.24.1990.5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000154546.32135.6E"},{"key":"2025092000561079000_96.24.1990.6","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2006.029306"},{"key":"2025092000561079000_96.24.1990.7","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.172551"},{"key":"2025092000561079000_96.24.1990.8","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000341280.31919.bd"},{"key":"2025092000561079000_96.24.1990.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.12.014"},{"key":"2025092000561079000_96.24.1990.10","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/oxfordjournals.aje.a115853","article-title":"The 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