{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:30:51Z","timestamp":1784835051733,"version":"3.55.0"},"reference-count":25,"publisher":"BMJ","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,7,19]]},"published-print":{"date-parts":[[2010,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To identify the prevalence, clinical characteristics, risk factors of hepatic complications after a Fontan operation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cross-sectional study of 139 Fontan patients who underwent cardiac CT scans out of a total of 204 patients who had undergone the Fontan procedure between 1986 and 2003. Mean age was 19.0\u00b16.3\u2005years and mean elapsed time since the initial Fontan operation was 11.5\u00b14.7\u2005years. Subjects' clinical features, echocardiograms, radiological features and biochemical test results were reviewed. Various non-invasive hepatic fibrosis blood markers were also evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty-seven patients had hepatic complications, including radiological features of liver cirrhosis (25.9%), thrombocytopenia (7.2%), hyperbilirubinaemia (20.9%) and hepatic masses (2.9%). Hepatic complications were also significantly associated with ventricular dysfunction (p=0.020), absence of fenestration (p=0.004), thrombus in the Fontan tract (p=0.027), sinus node dysfunction (p=0.034) and tachyarrhythmia (p&lt;0.001). In a multivariate analysis, the elapsed time since the initial Fontan operation was the only measure that was correlated with hepatic complications; the odds ratio of the post-Fontan duration of 16\u201320\u2005years to that of 0\u20135\u2005years was 9.00 (CI 2.24 to 36.17). The non-invasive hepatic fibrosis blood marker (Forns index) was also correlated with the elapsed time since the initial Fontan operation (r=0.718, p&lt;0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Late hepatic dysfunction and cirrhotic change were often seen in Fontan patients. Moreover, hepatic complications were correlated with the duration of Fontan circulation. Therefore, after a Fontan operation, regular evaluation of the hepatic condition is required\u2014for which some non-invasive hepatic fibrosis markers can be effectively used.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2010.201772","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T11:03:04Z","timestamp":1287399784000},"page":"1750-1755","source":"Crossref","is-referenced-by-count":164,"title":["Late hepatic complications after Fontan operation; non-invasive markers of hepatic fibrosis and risk factors"],"prefix":"10.1136","volume":"96","author":[{"given":"Jae Suk","family":"Baek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Sung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Beom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Sang","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Yun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Il","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Ah","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whal","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2010,10,18]]},"reference":[{"key":"2025092004314824000_96.21.1750.1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.052365"},{"key":"2025092004314824000_96.21.1750.2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/hrt.82.1.40","article-title":"Abnormalities in liver function and coagulation profile following the Fontan procedure","volume":"82","author":"van Nieuwenhuizen","year":"1999","journal-title":"Heart"},{"key":"2025092004314824000_96.21.1750.3","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2000.108903"},{"key":"2025092004314824000_96.21.1750.4","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951100012439"},{"key":"2025092004314824000_96.21.1750.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.06.043"},{"key":"2025092004314824000_96.21.1750.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.03.077"},{"key":"2025092004314824000_96.21.1750.7","unstructured":"Saliba T Dorkhom S O'Reilly EM . 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