{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:39:35Z","timestamp":1790426375290,"version":"4.1.0"},"reference-count":29,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2010,10,5]]},"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Many studies have shown that cardiac sympathetic nerve activity evaluated by [<jats:sup>123<\/jats:sup>I]m-iodobenzylguanidine ([<jats:sup>123<\/jats:sup>I]MIBG) scintigraphic study during a stable period is useful for determining the prognosis of patients with chronic heart failure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine whether results of this imaging method performed 3\u2005weeks after the onset of ST-segment elevation myocardial infarction (STEMI) are a reliable prognostic marker for patients with STEMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study analysed findings for 213 consecutive patients with STEMI undergoing [<jats:sup>123<\/jats:sup>I]MIBG scintigraphy. The left ventricular (LV) end-diastolic and end-systolic volume and LV ejection fraction (EF) were determined by left ventriculography or echocardiography 3\u2005weeks after the onset of STEMI. The delayed total defect score, heart-to-mediastinum ratio and washout rate (WR) were also determined from [<jats:sup>123<\/jats:sup>I]MIBG scintigraphy at the same time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 213 patients, 46 experienced major adverse cardiac events (MACE) during the study. The median follow-up period was 982\u2005days. Patients were divided into an event-free group (n=167; 78.4%) and a MACE group (n=46; 21.6%). The LV and [<jats:sup>123<\/jats:sup>I]MIBG scintigraphic parameters in the event-free group were better than those in the MACE group. Multivariate Cox regression analyses revealed that WR was a significant predictor of MACE along with oral nicorandil (ATP-sensitive potassium channel opener) treatment and undergoing percutaneous coronary intervention. On Kaplan\u2013Meier analysis, the event-free rate of patients with a WR&lt;40% was significantly higher than that in patients with a WR\u226540% (p&lt;0.001). Even when confined to patients with LVEF&gt;45%, WR was a predictor of MACE, pump failure death, cardiac death and progression of heart failure in patients with STEMI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>WR evaluated by [<jats:sup>123<\/jats:sup>I]MIBG scintigraphy 3\u2005weeks after the onset of STEMI is a significant predictor of MACE in patients with STEMI, independent of LVEF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.2010.204149","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T20:25:59Z","timestamp":1289334359000},"page":"20-26","source":"Crossref","is-referenced-by-count":32,"title":["Prognostic value of cardiac sympathetic nerve activity evaluated by [<sup>123<\/sup>I]m-iodobenzylguanidine imaging in patients with ST-segment elevation myocardial 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