{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:28:14Z","timestamp":1791444494268,"version":"4.3.3"},"reference-count":33,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"accepted":{"date-parts":[[2011,2,8]]},"published-print":{"date-parts":[[2011,5,15]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine whether once-daily esomeprazole 40\u2005mg or 20\u2005mg compared with placebo reduces the incidence of peptic ulcers over 26\u2005weeks of treatment in patients taking low-dose acetylsalicylic acid (ASA) and who are at risk for ulcer development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Multinational, randomised, blinded, parallel-group, placebo-controlled trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Cardiology, primary care and gastroenterology centres (n=240).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>\n                     <jats:italic>Helicobacter pylori<\/jats:italic>-negative patients taking daily low-dose ASA (75\u2013325\u2005mg), who fulfilled one or more of the following criteria: age \u226518\u2005years with history of uncomplicated peptic ulcer; age \u226560\u2005years with either stable coronary artery disease, upper gastrointestinal symptoms and five or more gastric\/duodenal erosions, or low-dose ASA treatment initiated within 1\u2005month of randomisation; or age \u226565\u2005years. All patients were ulcer-free at study entry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Once-daily, blinded treatment with esomeprazole 40\u2005mg, 20\u2005mg or placebo for 26\u2005weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>The primary end point was the occurrence of endoscopy-confirmed peptic ulcer over 26\u2005weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2426 patients (52% men; mean age 68\u2005years) were randomised. After 26\u2005weeks, esomeprazole 40\u2005mg and 20\u2005mg significantly reduced the cumulative proportion of patients developing peptic ulcers; 1.5% of esomeprazole 40\u2005mg and 1.1% of esomeprazole 20\u2005mg recipients, compared with 7.4% of placebo recipients, developed peptic ulcers (both p&lt;0.0001 vs placebo). Esomeprazole was generally well tolerated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Acid-suppressive treatment with once-daily esomeprazole 40\u2005mg or 20\u2005mg reduces the occurrence of peptic ulcers in patients at risk for ulcer development who are taking low-dose ASA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>ClinicalTrials.gov identifier: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT00441727\">NCT00441727<\/jats:ext-link>.<\/jats:p>\n               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