{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:56:27Z","timestamp":1768902987804,"version":"3.49.0"},"reference-count":27,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1977,10,1]]},"DOI":"10.1136\/hrt.39.10.1058","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"1058-1066","source":"Crossref","is-referenced-by-count":119,"title":["Effect of verapamil studied by programmed electrical stimulation of the heart in patients with paroxysmal re-entrant supraventricular tachycardia."],"prefix":"10.1136","volume":"39","author":[{"given":"H J","family":"Wellens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F W","family":"Bar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Duren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K I","family":"Lie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Dohmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0002-9149(74)90755-3","article-title":"The effects of atrial pacing site on A-V nodal function (abstract)","volume":"33","author":"Amat, F.; Denes, P.; Wu, D.; Pietras, R.J.; Rosen, K.","year":"1974","unstructured":"Amat, F., Denes, P., Wu, D., Pietras, R. J., and Rosen, K. (1974). The effects of atrial pacing site on A-V nodal function (abstract). American Journal of Cardiology, 33, 123.","journal-title":"American Journal of Cardiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1161\/01.CIR.50.2.283","article-title":"Effect of atrial stimulation site on the electrophysiological properties of the atrioventricular node in man","volume":"50","author":"Batsford, W.; Akhtar, M.; Caracta, A.R.; Josephson, M.E.; Seides, S.F.; Damato, A.N.","year":"1974","unstructured":"Batsford, W., Akhtar, M., Caracta, A. R., Josephson, M. E., Seides, S. F., and Damato, A. N. (1974). Effect of atrial stimulation site on the electrophysiological properties of the atrioventricular node in man. Circulation, 50, 283-292.","journal-title":"Circulation"},{"key":"ref_3","first-page":"634","article-title":"Isoptin zur Behandlung der tachykarden Form des Vorhofflatterns","volume":"62","author":"Bender, F.","year":"1967","unstructured":"Bender, F. (1967). Isoptin zur Behandlung der tachykarden Form des Vorhofflatterns. Medizinische Klinik, 62, 634-636.","journal-title":"Medizinische Klinik"},{"key":"ref_4","first-page":"1120","article-title":"Behandlung tachykarder Rhythmusst6rungen des Herzens durch Beta-Rezeptorenblockade des Atrioventrikulargewebes","volume":"1","author":"Bender, F.; Kojima, N.; Reploh, H.D.; Oelmann, G.","year":"1966","unstructured":"Bender, F., Kojima, N., Reploh, H. D., and Oelmann, G. (1966). Behandlung tachykarder Rhythmusst6rungen des Herzens durch Beta-Rezeptorenblockade des Atrioventrikulargewebes. Medizinische Welt, 1, 1120-1123.","journal-title":"Medizinische Welt"},{"key":"ref_5","first-page":"147","article-title":"Diagnostische Probleme beim L","author":"Both, A.; Seipel, L.; Loogen, F.","year":"1975","unstructured":"Both, A., Seipel, L., and Loogen, F. (1975). Diagnostische Probleme beim L.G.L. Syndrom. In His-Bundel-Elektrographie, p. 147. Ed. by L. Seipel, F. Loogen, and A. Both. Schattauer Verlag, Stuttgart."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/01.RES.34.2.204","article-title":"Effect of verapamil on the normal action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers","volume":"34","author":"Cranefield, P.F.; Aronson, R.S.; Wit, A.L.","year":"1974","unstructured":"Cranefield, P. F., Aronson, R. S., and Wit, A. L. (1974). Effect of verapamil on the normal action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers. Circulation Research, 34, 204-213.","journal-title":"Circulation Research"},{"key":"ref_7","article-title":"Demonstration of dual A-V nodal path-","author":"Denes, P.; D., Wu; Dhingra, R.C.; Chuquimia, R.; Rosen, K.","year":"1973","unstructured":"Denes, P., Wu. D., Dhingra, R. C., Chuquimia, R., and Rosen, K. (1973). Demonstration of dual A-V nodal path-"},{"key":"ref_8","article-title":"are given elsewhere","year":"1975","unstructured":"are given elsewhere (Wellens et al., 1975)."},{"key":"ref_9","first-page":"87","article-title":"Comparison of verapamil and practolol in paroxysmal supraventricular tachycardia","volume":"4","author":"Hirtel, G.; Hartikainen, M.","year":"1976","unstructured":"Hirtel, G., and Hartikainen, M. (1976). Comparison of verapamil and practolol in paroxysmal supraventricular tachycardia. European Journal of Cardiology, 4, 87-90.","journal-title":"European Journal of Cardiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/hrt.35.7.734","article-title":"Action of verapamil on sinus node, atrioventricular, and intraventricular conduction","volume":"35","author":"Husaini, M.H.; Kvasnicka, J.; Ryden, L.; Holmberg, S.","year":"1973","unstructured":"Husaini, M. H., Kvasnicka, J., Ryden, L., and Holmberg, S. (1973). Action of verapamil on sinus node, atrioventricular, and intraventricular conduction. British Heart Journal, 35, 734-737.","journal-title":"British Heart Journal"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF00586221","article-title":"Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors","volume":"335","author":"Kohlhardt, M.; Bauer, B.; Krause, H.","year":"1972","unstructured":"Kohlhardt, M., Bauer, B., and Krause, H. (1972). Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors. Pflugers Archiv far die gesamte Physiologie, 335, 309-322.","journal-title":"Pflugers Archiv far die gesamte Physiologie"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1136\/pgmj.50.585.447","article-title":"Verapamil in the treatment of paroxysmal supraventricular tachycardia","volume":"50","author":"Krikler, D.; Spurrell, R.","year":"1974","unstructured":"Krikler, D., and Spurrell, R. (1974). Verapamil in the treatment of paroxysmal supraventricular tachycardia. Postgraduate Medical Journal, 50, 447-453.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_13","first-page":"433","article-title":"Der Einfluss von Verapamil auf die atrio-ventrikulare Uberleitung. Lokalisation des Wirkungsortes mit His-Bulndel Elektrogrammen. Verhandlungen der Deutschen Gesellschaft far","volume":"37","author":"Neuss, H.; Schlepper, M.","year":"1971","unstructured":"Neuss, H., and Schlepper, M. (1971). Der Einfluss von Verapamil auf die atrio-ventrikulare Uberleitung. Lokalisation des Wirkungsortes mit His-Bulndel Elektrogrammen. Verhandlungen der Deutschen Gesellschaft far Kreislaufforschung, 37, 433-438.","journal-title":"Kreislaufforschung"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/pgmj.50.583.270","article-title":"The effect of verapamil on the cardiac conduction system in man","volume":"50","author":"Roy, P.R.; Spurrell, R.A.J.; Sowton, E.","year":"1974","unstructured":"Roy, P. R., Spurrell, R. A. J., and Sowton, E. (1974). The effect of verapamil on the cardiac conduction system in man. Postgraduate Medical Journal, 50, 270-275.","journal-title":"Postgraduate Medical Journal"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/cvr\/5.4.419","article-title":"Immediate effects of intravenous verapamil on atrial fibrillation","volume":"5","author":"Schamroth, L.","year":"1971","unstructured":"Schamroth, L. (1971). Immediate effects of intravenous verapamil on atrial fibrillation. Cardiovascular Research, 5, 419-424.","journal-title":"Cardiovascular Research"},{"key":"ref_16","author":"Schamroth, L.; Krikler, D.M.; Garrett, C.","year":"1972","unstructured":"Schamroth, L., Krikler, D. M., and Garrett, C. (1972)."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/bmj.1.5801.660","article-title":"Immediate effects of intravenous verapamil in cardiac arrhythmias","volume":"1","unstructured":"Immediate effects of intravenous verapamil in cardiac arrhythmias. British Medical Journal, 1, 660-662.","journal-title":"British Medical Journal"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1136\/hrt.36.3.256","article-title":"Effects of verapamil on electrophysiological properties of anomalous atrioventricular connexion in Wolff-ParkinsonWhite syndrome","volume":"36","author":"Spurrell, R.A.J.; Krikler, D.M.; Sowton, E.","year":"1974","unstructured":"Spurrell, R. A. J., Krikler, D. M., and Sowton, E. (1974a). Effects of verapamil on electrophysiological properties of anomalous atrioventricular connexion in Wolff-ParkinsonWhite syndrome. British Heart Journal, 36, 256-264.","journal-title":"British Heart Journal"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/0002-9149(74)90247-1","article-title":"Concealed bypasses of the atrioventricular node in patients with paroxysmal supraventricular tachycardia revealed by intracardiac electrical stimulation and verapamil","volume":"33","author":"Spurrell, R.A.J.; Krikler, D.M.; Sowton, E.","year":"1974","unstructured":"Spurrell, R. A. J., Krikler, D. M., and Sowton, E. (1974b). Concealed bypasses of the atrioventricular node in patients with paroxysmal supraventricular tachycardia revealed by intracardiac electrical stimulation and verapamil. American Journal of Cardiology, 33, 590-595.","journal-title":"American Journal of Cardiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/hrt.36.6.570","article-title":"Cycle length alternation in supraventricular tachycardia after administration of verapamil","volume":"36","author":"Vohra, J.; Hunt, D.; Stuckey, J.; Sloman, G.","year":"1974","unstructured":"Vohra, J., Hunt, D., Stuckey, J., and Sloman, G. (1974a). Cycle length alternation in supraventricular tachycardia after administration of verapamil. British Heart Journal, 36, 570-576.","journal-title":"British Heart Journal"},{"key":"ref_21","first-page":"36","article-title":"Verapamil induced premature beats before reversion of supraventricular tachycardia","volume":"7","author":"Vohra, J.; Peter, T.; Hunt, D.; Sloman, G.","year":"1974","unstructured":"Vohra, J., Peter, T., Hunt, D., and Sloman, G. (1974b). Verapamil induced premature beats before reversion of supraventricular tachycardia. British Heart J7ournal, 36, 1186-1193.","journal-title":"British Heart"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1161\/01.CIR.52.1.58","article-title":"The role of an accessory atrioventricular pathway in reciprocoal tachycardia. Observations in patients with and without the Wolff-Parkinson-White syndrome","volume":"52","author":"Wellens, H.J.J.; Durrer, D.","year":"1975","unstructured":"Wellens, H. J. J., and Durrer, D. (1975). The role of an accessory atrioventricular pathway in reciprocoal tachycardia. Observations in patients with and without the Wolff-Parkinson-White syndrome. Circulation, 52, 58-72.","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/01.CIR.52.5.779","article-title":"Effect of digitalis in patients with paroxysmal atrioventricular nodal tachycardia","volume":"52","author":"Wellens, H.J.J.; Duren, D.R.; Liem, K.L.; Lie, K.I.","year":"1975","unstructured":"Wellens, H. J. J., Duren, D. R., Liem, K. L., and Lie, K. I. (1975). Effect of digitalis in patients with paroxysmal atrioventricular nodal tachycardia. Circulation, 52, 779-788.","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.RES.35.3.413","article-title":"Effect of verapamil on the sinoatrial and atrioventricular nodes of the rabbit and the mechanism by which it arrests re-entrant atrioventricular nodal tachycardia","volume":"35","author":"Wit, A.L.; Cranefield, P.F.","year":"1974","unstructured":"Wit, A. L., and Cranefield, P. F. (1974). Effect of verapamil on the sinoatrial and atrioventricular nodes of the rabbit and the mechanism by which it arrests re-entrant atrioventricular nodal tachycardia. Circulation Research, 35, 413-425.","journal-title":"Circulation Research"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.CIR.50.4.665","article-title":"The effects of propranolol on induction of A-V nodal re-entrant paroxysmal tachycardia","volume":"50","author":"Wu, D.; Denes, P.; Dhingra, R.; Khan, A.; Rosen, K.","year":"1974","unstructured":"Wu, D., Denes, P., Dhingra, R., Khan, A., and Rosen, K. (1974). The effects of propranolol on induction of A-V nodal re-entrant paroxysmal tachycardia. Circulation, 50, 665-677.","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/01.CIR.52.2.201","article-title":"The effects of ouabain on induction of atrioventricular nodal re-entrant paroxysmal supraventricular tachycardia","volume":"52","author":"Wu, D.; Wyndham, C.; Amat-Y-Leon, F.; Denes, P.; Dhingra, R.C.; Rosen, K.","year":"1975","unstructured":"Wu, D., Wyndham, C., Amat-Y-Leon, F., Denes, P., Dhingra, R. C., and Rosen, K. (1975). The effects of ouabain on induction of atrioventricular nodal re-entrant paroxysmal supraventricular tachycardia. Circulation, 52, 201-207.","journal-title":"Circulation"},{"key":"ref_27","first-page":"85","article-title":"Recent observations supporting the role of slow current in cardiac electrophysiology. In The Conduction System of the Heart","author":"Zipes, D.P.","year":"1975","unstructured":"Zipes, D. P. (1975). Recent observations supporting the role of slow current in cardiac electrophysiology. In The Conduction System of the Heart, p. 85. Ed. by H. J. J. Wellens, K. I. Lie, and M. J. Janse. Lea and Febiger, Philadelphia."}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.39.10.1058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:47:25Z","timestamp":1601081245000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.39.10.1058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,10,1]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1977,10,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.39.10.1058","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1977,10,1]]}}}