{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:06:14Z","timestamp":1791410774104,"version":"4.3.3"},"reference-count":22,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1982,12,1]]},"DOI":"10.1136\/hrt.48.6.541","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"541-545","source":"Crossref","is-referenced-by-count":48,"title":["Haemodynamic and hormonal effects of captopril in primary pulmonary hypertension."],"prefix":"10.1136","volume":"48","author":[{"given":"H","family":"Ikram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A H","family":"Maslowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Nicholls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Espiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F T","family":"Hull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"130","article-title":"Primary pulmonary hypertension of unusually long duration","volume":"32","author":"Charters, A.D.; WdeC, Baker","year":"1970","unstructured":"Charters AD, Baker WdeC. Primary pulmonary hypertension of unusually long duration. Br Heart3J 1970; 32: 130-3."},{"key":"ref_2","article-title":"Regression of primary pulmonary hypertension. Br HeartJ 1976; 38: 264-70. Haemodynamic and homonal effects ofcaptopril in primary pulmonary hypertnsion","author":"Bourdillon, P.D.V.; Oakley, C.M.","unstructured":"Bourdillon PDV, Oakley CM. Regression of primary pulmonary hypertension. Br HeartJ 1976; 38: 264-70. Haemodynamic and homonal effects ofcaptopril in primary pulmonary hypertnsion"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3949\/ccjm.47.4.275","article-title":"Primary pulmonary hypertension in adults. Clinical features, catheterization findings and long-term follow-up","volume":"47","author":"Gupta, B.D.; Moodie, D.S.; Hodgman, JR","year":"1980","unstructured":"Gupta BD, Moodie DS, Hodgman JR. Primary pulmonary hypertension in adults. Clinical features, catheterization findings and long-term follow-up. Cleve Clin Q 1980; 47: 275-84.","journal-title":"Cleve Clin Q"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/01.RES.35.2.256","article-title":"Hypoxic pulmonary vasoconstriction in the rat. The necessary role of angiotensin II","volume":"35","author":"Berkov, S.","year":"1974","unstructured":"Berkov S. Hypoxic pulmonary vasoconstriction in the rat. The necessary role of angiotensin II. Circ Res 1974; 35: 256-61.","journal-title":"Circ Res"},{"key":"ref_5","first-page":"57","article-title":"Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat","volume":"33","author":"Zakheim, R.M.; Mattioli, L.; Molteni, A.; Mullis, K.B.; Bartley, J.","year":"1975","unstructured":"Zakheim RM, Mattioli L, Molteni A, Mullis KB, Bartley J. Prevention of pulmonary vascular changes of chronic alveolar hypoxia by inhibition of angiotensin I-converting enzyme in the rat. Lab Invest 1975; 33: 57-61.","journal-title":"Lab Invest"},{"key":"ref_6","first-page":"78591","article-title":"Effects of the converting enzyme inhibitor (SQ 20881) on the pulmonary circulation in man","volume":"67","author":"Niarchos, A.P.; Roberts, A.J.; Laragh, J.H.","year":"1979","unstructured":"Niarchos AP, Roberts AJ, Laragh JH. Effects of the converting enzyme inhibitor (SQ 20881) on the pulmonary circulation in man. AmJ7 Med 1979; 67: 78591.","journal-title":"AmJ7 Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/pgmj.57.664.115","article-title":"Effects ofcaptopril (SQ 14,225) in a patient with primary pulmonary hypertension","volume":"57","author":"Horowitz, J.D.; Brennan, J.B.; Oliver, L.E.; Harding, D.; Goble, A.J.; Louis, W.J.","year":"1981","unstructured":"Horowitz JD, Brennan JB, Oliver LE, Harding D, Goble AJ, Louis WJ. Effects ofcaptopril (SQ 14,225) in a patient with primary pulmonary hypertension. Postgrad Med J 1981; 57: 115-6.","journal-title":"Postgrad Med J"},{"key":"ref_8","first-page":"71","article-title":"Haemodynamic, hormonal, and electrolyte responses to captopril in resistant heart failure","volume":"i:","author":"Maslowski, A.H.; Ikram, H.; Nicholls, M.G.; Espiner, E.A.","year":"1981","unstructured":"Maslowski AH, Ikram H, Nicholls MG, Espiner EA. Haemodynamic, hormonal, and electrolyte responses to captopril in resistant heart failure. Lancet 1981; i: 71-4.","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0002-9149(78)90731-2","article-title":"Assessment of cardiac performance with quantitative radionuclide angiocardiography: right ventricular ejection fraction with reference to findings in chronic obstructive pulmonary disease","volume":"41","author":"Berger, H.J.; Matthay, R.A.; Loke, J.; Marshall, R.C.; Gottschalk, A.; Zaret, B.L.","year":"1978","unstructured":"Berger HJ, Matthay RA, Loke J, Marshall RC, Gottschalk A, Zaret BL. Assessment of cardiac performance with quantitative radionuclide angiocardiography: right ventricular ejection fraction with reference to findings in chronic obstructive pulmonary disease. Am J Cardiol 1978; 41: 897-905.","journal-title":"Am J Cardiol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/01.RES.6.1.10","article-title":"Action of hypoxia on the pulmonary vasculature","volume":"6","author":"Rivera-Estrada, C.; Saltzman, P.W.; Singer, D.; Katz, L.N.","year":"1958","unstructured":"Rivera-Estrada C, Saltzman PW, Singer D, Katz LN. Action of hypoxia on the pulmonary vasculature. Circ Res 1958; 6: 10-4.","journal-title":"Circ Res"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0002-9149(72)90151-8","article-title":"Treadmill exercise in assessment of the functional capacity of patients with cardiac disease","volume":"30","author":"Patterson, J.A.; Naughton, J.; Pietras, R.J.; Gunnar, R.M.","year":"1972","unstructured":"Patterson JA, Naughton J, Pietras RJ, Gunnar RM. Treadmill exercise in assessment of the functional capacity of patients with cardiac disease. Am J Cardiol 1972; 30:757-62.","journal-title":"Am J Cardiol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/icb.1948.9","article-title":"The action of renin and hypertensin on the pulmonary and hepatic circulations","volume":"26","author":"Reid, G.; Jenkins, H.A.","year":"1948","unstructured":"Reid G, Jenkins HA. The action of renin and hypertensin on the pulmonary and hepatic circulations. Aust J Exp Biol Med Sci 1948; 26: 81-91.","journal-title":"Aust J Exp Biol Med Sci"},{"key":"ref_13","first-page":"49","article-title":"The effects of synthetic hypertensin on the systemic and pulmonary circulations in man","volume":"20","author":"Segel, N.; Harris, P.; Bishop, J.M.","year":"1960","unstructured":"Segel N, Harris P, Bishop JM. The effects of synthetic hypertensin on the systemic and pulmonary circulations in man. Clin Sci 1960; 20: 49-61.","journal-title":"Clin Sci"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1152\/jappl.1968.25.5.560","article-title":"Hypoxic pulmonary vasoconstriction: role of perivascular tissue","volume":"25","author":"TC, Jr, Lloyd","year":"1968","unstructured":"Lloyd TC Jr. Hypoxic pulmonary vasoconstriction: role of perivascular tissue. J Appl Physiol 1968; 25: 560-5.","journal-title":"J Appl Physiol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00005344-198103000-00008","article-title":"Feline hypoxic pulmonary vasoconstriction is not blocked by the angiotensin I-converting enzyme inhibitor, captopril","volume":"3","author":"Prewitt, R.L.; Leffler, C.W.","year":"1981","unstructured":"Prewitt RL, Leffler CW. Feline hypoxic pulmonary vasoconstriction is not blocked by the angiotensin I-converting enzyme inhibitor, captopril. J Cardio Pharm 1981; 3: 293-8.","journal-title":"J Cardio Pharm"},{"key":"ref_16","first-page":"28","article-title":"Acute and chronic effects of captopril in severe pulmonary hypertension of different origin. Abstract of symposium on primary pulmonary hypertension","volume":"Vienna,","author":"Schmengler, K.; Stumpe, K.O.; Doencke, Bette; L.","year":"1982","unstructured":"Schmengler K, Stumpe KO, Doencke, Bette L. Acute and chronic effects of captopril in severe pulmonary hypertension of different origin. Abstract of symposium on primary pulmonary hypertension. European Society of Cardiology, Vienna, 18 March 1982, p.28.","journal-title":"European Society of Cardiology"},{"key":"ref_17","first-page":"29","article-title":"Captopril for primary pulmonary hypertension. The problem of variability in assessing chronic drug therapy. Abstract of symposium on primary pulmonary hypertension","volume":"Vienna,","author":"Rich, S.; Rosen, K.M.","year":"1982","unstructured":"Rich S, Rosen KM. Captopril for primary pulmonary hypertension. The problem of variability in assessing chronic drug therapy. Abstract of symposium on primary pulmonary hypertension. European Society of Cardiology, Vienna, 18 March 1982, p.29.","journal-title":"European Society of Cardiology"},{"key":"ref_18","article-title":"WHO report on primaty pulmonary hypertension","author":"Hatano, S.","year":"1975","unstructured":"Hatano S, Strasser T, eds. WHO report on primaty pulmonary hypertension. Geneva: WHO 1975."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0002-9149(82)90279-X","article-title":"Hemodynamic correlates of right ventricular ejection fraction measured with gated radionuclide angiography","volume":"49","author":"Korr, K.S.; Gandsman, E.J.; Winkler, M.L.; Shulman, R.S.; Bough, E.W.","year":"1982","unstructured":"Korr KS, Gandsman EJ, Winkler ML, Shulman RS, Bough EW. Hemodynamic correlates of right ventricular ejection fraction measured with gated radionuclide angiography. AmJr Cardiol 1982; 49: 71-7.","journal-title":"AmJr Cardiol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1378\/chest.71.2_Supplement.281","article-title":"Right ventricular ejection fraction in severe chronic airway obstruction","volume":"71","author":"JH, Jr, Ellis; D, Kirch; PP, Steele","year":"1977","unstructured":"Ellis JH Jr, Kirch D, Steele PP. Right ventricular ejection fraction in severe chronic airway obstruction. Chest 1977; 71: 281-2.","journal-title":"Chest"},{"key":"ref_21","first-page":"1150","article-title":"Left ventricular function in chronic pulmonary hypertension","volume":"41","year":"1980","unstructured":"Krayenbuehl HP, Turina J, Hess 0. Left ventricular function in chronic pulmonary hypertension. Am J Cardiol 1980; 41: 1150-8.","journal-title":"Am J Cardiol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/0002-9149(74)90634-1","article-title":"Dimensional changes ofthe left ventricle during acute pulmonary arterial hypertension in dogs","volume":"33","author":"Stool, E.W.; Mullins, C.B.; Leshin, S.J.; Mitchell, J.H.","year":"1974","unstructured":"Stool EW, Mullins CB, Leshin SJ, Mitchell JH. Dimensional changes ofthe left ventricle during acute pulmonary arterial hypertension in dogs. Am J Cardiol 1974; 33: 868-75.","journal-title":"Am J Cardiol"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.48.6.541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:56:13Z","timestamp":1601081773000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.48.6.541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12,1]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,12,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.48.6.541","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1982,12,1]]}}}