{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T08:29:39Z","timestamp":1772612979187,"version":"3.50.1"},"reference-count":15,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1983,5,1]]},"DOI":"10.1136\/hrt.49.5.447","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"447-451","source":"Crossref","is-referenced-by-count":66,"title":["Side effects of amrinone therapy."],"prefix":"10.1136","volume":"49","author":[{"given":"P T","family":"Wilsmhurst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Webb-Peploe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1056\/NEJM197812212992501","article-title":"Hemodynamic assessment of amrinone: a new inotropic agent","volume":"299","author":"Benotti, JR, Grossman; W, Braunwald; E, Davolos; DD, Alousi; A.A.","year":"1978","unstructured":"Benotti JR, Grossman W, Braunwald E, Davolos DD, Alousi AA. Hemodynamic assessment of amrinone: a new inotropic agent. N EnglJa Med 1978; 299: 1373-7.","journal-title":"N EnglJa Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0002-9149(80)90229-5","article-title":"Sustained beneficial effects of oral amrinone on cardiac and renal function in patients with severe congestive heart failure","volume":"415","author":"LeJemtel, T.H.; Keung, E.; Ribner, H.S.","year":"1980","unstructured":"LeJemtel TH, Keung E, Ribner HS, et al. Sustained beneficial effects of oral amrinone on cardiac and renal function in patients with severe congestive heart failure. Am J Cardiol 1980; 415: 123-9.","journal-title":"Am J Cardiol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/hrt.49.1.77","article-title":"The haemodynamic effects of intravenous amrinone in patients with impaired left ventricular function","volume":"49","author":"Wilmshurst, P.T.; Thompson, D.S.; Jenkins, B.S.; Coltart, D.J.; Webb-Peploe, M.M.","year":"1983","unstructured":"Wilmshurst PT, Thompson DS, Jenkins BS, Coltart DJ, Webb-Peploe MM. The haemodynamic effects of intravenous amrinone in patients with impaired left ventricular function. Br Heart J 1983; 49: 77-82.","journal-title":"Br Heart J"},{"key":"ref_4","first-page":"120","article-title":"Amrinone","volume-title":"and biochenical propetie of drug substances","author":"Alousi, A.A.; Edelson, J.","year":"1981","unstructured":"Alousi AA, Edelson J. Amrinone. In: Goldberg ME, ed. Pharmacological and biochenical propetie of drug substances. Washington DC: American Pharmaceutical Association, 1981: 120-46."},{"key":"ref_5","first-page":"264","article-title":"High performance liquid chromatographic analysis of amrinone and its N-acetyl derivative in plasma. Pharmacokinetics of amrinone in the dog","author":"Kullberg, M.P.; Dorrbecker, B.; Lennon, J.; Rowe, E.; Edelson, J.","year":"1980","unstructured":"Kullberg MP, Dorrbecker B, Lennon J, Rowe E, Edelson J. High performance liquid chromatographic analysis of amrinone and its N-acetyl derivative in plasma. Pharmacokinetics of amrinone in the dog.J Chromatogr 1980; 187: 264-70.","journal-title":"J Chromatogr"},{"key":"ref_6","first-page":"1","article-title":"Estudio de los efectos hemodinamicos de diferentes dosis de un nuevo inotropico: la amrinona","volume":"49","author":"Cardenas, M.; Vidaurri, A.","year":"1979","unstructured":"Cardenas M, Vidaurri A. Estudio de los efectos hemodinamicos de diferentes dosis de un nuevo inotropico: la amrinona. Arch Inst Cardiol Mex 1979; 49: %1-8.","journal-title":"Arch Inst Cardiol Mex"},{"key":"ref_7","first-page":"1098104","article-title":"Amrinone: a new non-glycosidic, non-adrenergic carditonic agent effective in the treatment of intractable myocardial failure in man","volume":"59","author":"LeJemtel, T.H.; Keung, E.; Sonnenblick, E.H.","year":"1979","unstructured":"LeJemtel TH, Keung E, Sonnenblick EH, et al. Amrinone: a new non-glycosidic, non-adrenergic carditonic agent effective in the treatment of intractable myocardial failure in man. Circulation 1979; 59: 1098104.","journal-title":"Circulation"},{"issue":"838 44","key":"ref_8","article-title":"Beneficial effects of anrinone-hydralazine combination on resting hemodynamics and exercise capacity in patients with severe congestive heart failure","volume":"63","author":"Siegel, L.A.; Keung, E.; Siskind, S.J.","year":"1981","unstructured":"Siegel LA, Keung E, Siskind SJ, et al. Beneficial effects of anrinone-hydralazine combination on resting hemodynamics and exercise capacity in patients with severe congestive heart failure. Circulaion 1981; 63: 838 44.","journal-title":"Circulaion"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1056\/NEJM197911223012118","article-title":"Thrombocytopenia and fever in a patient taking amrinone (letter)","volume":"301","author":"Rubin, S.A.; Lee, S.; O'Connor, L.; Hubenette, A.; Tober, J.; Swan, H.J.C.","year":"1979","unstructured":"Rubin SA, Lee S, O'Connor L, Hubenette A, Tober J, Swan HJC. Thrombocytopenia and fever in a patient taking amrinone (letter). NEnglJ Med 1979; 301: 1185.","journal-title":"NEnglJ Med"},{"key":"ref_10","article-title":"Possible adverse effects of long-term amnrinone administration in heart failure","author":"Dunkman, W.B.; Wilen, M.; Franciosa, J.A.","year":"1981","unstructured":"Dunkman WB, Wilen M, Franciosa JA. Possible adverse effects of long-term amnrinone administration in heart failure. Circulation 1981; 64 (suppl IV): 307.","journal-title":"Circulation; 64 (suppl IV"},{"key":"ref_11","first-page":"351","article-title":"Chapter 67, Vasenlitis","volume-title":"Hamison's principles of internal medicine, 9th international student edition","author":"Mannik, M.; Gilliband, B.C.","year":"1980","unstructured":"Mannik M, Gilliband BC. Chapter 67, Vasenlitis. In: Isselbacher KJ, Adams RD, Braunwald E, Petersdorf RG, Wilson JD, eds. Hamison's principles of internal medicine, 9th international student edition. Tokyo: McGraw-Hill, Kogakusha 1980: 351-5."},{"key":"ref_12","first-page":"775","article-title":"Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle","volume":"221","author":"Endoh, M.; Yamashita, S.; Taira, N.","year":"1982","unstructured":"Endoh M, Yamashita S, Taira N. Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle. J Pharmacol Exp Ther 1982; 221: 775-83.","journal-title":"J Pharmacol Exp Ther"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF00508835","article-title":"Involvement of cyclic AMP in the direct inotropic action of amrinone: biochemical and functional evidence","volume":"318","author":"Honeriager, P.; Schafer-Korting, M.; Reiter, M.","year":"1981","unstructured":"Honeriager P, Schafer-Korting M, Reiter M. Involvement of cyclic AMP in the direct inotropic action of amrinone: biochemical and functional evidence. Naunyn Schmiedebergs Arch Pharnacol 1981; 318: 112-20.","journal-title":"Naunyn Schmiedebergs Arch Pharnacol"},{"key":"ref_14","first-page":"592","article-title":"Central nervous system stimulants: the xanthines","volume-title":"The pharmacological basis of therapeutics","author":"Rail, T.W.","year":"1980","unstructured":"Rail TW. Central nervous system stimulants: the xanthines. In: Gilman AG, Goodman LS, Gilman A, eds. The pharmacological basis of therapeutics. 6th ed. London: MacMillan, 1980: 592-607.","edition":"6th ed"},{"key":"ref_15","first-page":"335","article-title":"Stimulation of gastric secretion in man","volume-title":"by theophylline ethylenediamine. Proc Soc Exp Biol Med 1949","volume":"71","author":"Krasnow, S.; Grossman, M.I.","unstructured":"Krasnow S, Grossman MI. Stimulation of gastric secretion in man by theophylline ethylenediamine. Proc Soc Exp Biol Med 1949; 71: 335-6."}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.49.5.447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T02:46:17Z","timestamp":1737427577000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.49.5.447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,5,1]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1983,5,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.49.5.447","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1983,5,1]]}}}