{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:25:40Z","timestamp":1780518340838,"version":"3.54.1"},"reference-count":3,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1984,9,1]]},"DOI":"10.1136\/hrt.52.3.358","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"358-359","source":"Crossref","is-referenced-by-count":4,"title":["Sotalol, hypokalaemia, syncope, and torsade de pointes."],"prefix":"10.1136","volume":"52","author":[{"given":"M J","family":"Antonaccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J N","family":"Lessem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L F","family":"Soyka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/j.1552-4604.1979.tb02521.x","article-title":"Long-term sotalol therapy in patients with arrhythmias","volume":"19","author":"Simon, A.; Berman, E.","year":"1979","unstructured":"Simon A, Berman E. Long-term sotalol therapy in patients with arrhythmias. J Clin Pharmacol 1979; 19: 547-56.","journal-title":"J Clin Pharmacol"},{"key":"ref_2","first-page":"17980","article-title":"Sotalolinduced torsade de pointes","volume":"107","author":"Kuck, K.H.; Kunze, K.P.; Roewer, N.; Bleifeld, W.","year":"1984","unstructured":"Kuck KH, Kunze KP, Roewer N, Bleifeld W. Sotalolinduced torsade de pointes. Am Heart J 1984; 107: 17980.","journal-title":"Am Heart J"},{"key":"ref_3","article-title":"Fagard et al's paper","volume-title":"51: 149-56) on ketanserin treatment in mildly hypertensive patients includes some haemorrheological aspects which might be noteworthy. The authors found a fall in pulmonary and systemic arterial resistance during treatment which they attribute exclusively to vasodilatation. Peripheral resistance, however, is composed of two components: vascular tone and the viscous hindrance of blood flow (for example, blood viscosity).' Blood viscosity is increased in essential hypertension' and can be decreased by ketanserin2 and other alpha1 antagonists.' This might bea contributory factor in the changes observed by Fagard et","author":"Sir","year":"1984","unstructured":"Sir, Fagard et al's paper (1984; 51: 149-56) on ketanserin treatment in mildly hypertensive patients includes some haemorrheological aspects which might be noteworthy. The authors found a fall in pulmonary and systemic arterial resistance during treatment which they attribute exclusively to vasodilatation. Peripheral resistance, however, is composed of two components: vascular tone and the viscous hindrance of blood flow (for example, blood viscosity).' Blood viscosity is increased in essential hypertension' and can be decreased by ketanserin2 and other alpha1 antagonists.' This might bea contributory factor in the changes observed by Fagard et al. In fact a closer look at their results seems to confirm this. Haemoglobin concentrations decrease and plasma volume is thought to increase with ketanserin, both of which would tend to lower blood viscosity3 and partly explain the findings."}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.52.3.358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:58:37Z","timestamp":1601081917000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.52.3.358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9,1]]},"references-count":3,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,9,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.52.3.358","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1984,9,1]]}}}