{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:22:43Z","timestamp":1792657363793,"version":"4.5.0"},"reference-count":40,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1986,2,1]]},"DOI":"10.1136\/hrt.55.2.204","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"204-210","source":"Crossref","is-referenced-by-count":45,"title":["Effect of parasympathetic impairment on the haemodynamic response to handgrip in Chagas's heart disease."],"prefix":"10.1136","volume":"55","author":[{"given":"J A","family":"Marin-Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B C","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Gallo Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L F","family":"Junqueira Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D S","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"issue":"229 44","key":"ref_1","article-title":"The circulatory effects ofsustained voluntary muscle contraction","volume":"27","author":"Lind, A.R.; Taylor, S.H.; Humphreys, P.W.; Kennelly, B.M.; Donald, K.W.","year":"1964","unstructured":"Lind AR, Taylor SH, Humphreys PW, Kennelly BM, Donald KW. The circulatory effects ofsustained voluntary muscle contraction. Clin Sci 1964; 27: 229 44.","journal-title":"Clin Sci"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/01.CIR.41.2.173","article-title":"Cardiovascular responses to static exercise","volume":"41","author":"Lind, A.R.","year":"1970","unstructured":"Lind AR. Cardiovascular responses to static exercise. Circulation 1970; 41: 173-6.","journal-title":"Circulation"},{"key":"ref_3","first-page":"11","article-title":"Isometric exercise and the cardiovascular system","volume":"41","author":"Nutter, D.O.; Schlant, R.C.; Hurst, JR","year":"1972","unstructured":"Nutter DO, Schlant RC, Hurst JR. Isometric exercise and the cardiovascular system. Mod Concepts Cardiovasc Dis 1972; 41: 11-5.","journal-title":"Mod Concepts Cardiovasc Dis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.me.25.020174.002101","article-title":"Static (isometric) exercise and the heart: physiological and clinical considerations","volume":"25","author":"Mitchell, J.H.; Wildenthal, K.","year":"1974","unstructured":"Mitchell JH, Wildenthal K. Static (isometric) exercise and the heart: physiological and clinical considerations. Annu Rev Med 1974; 25: 369-81.","journal-title":"Annu Rev Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.ph.45.030183.001103","article-title":"Reflex control of blood pressure during exercise","volume":"45","author":"Ludbrook, J.","year":"1983","unstructured":"Ludbrook J. Reflex control of blood pressure during exercise. Annu Rev Physiol 1983; 45: 155-68.","journal-title":"Annu Rev Physiol"},{"key":"ref_6","first-page":"706","article-title":"Muscular factors which determine the cardiovascular responses to sustained and rhythmic exercise","volume":"96","author":"Lind, A.R.; McNicol, G.W.","year":"1967","unstructured":"Lind AR, McNicol GW. Muscular factors which determine the cardiovascular responses to sustained and rhythmic exercise. Can Med Assoc J 1967; 96: 706-13.","journal-title":"Can Med Assoc J"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1172\/JCI107731","article-title":"Autonomic mechanisms in hemodynamic responses to isometric exercise","volume":"54","author":"Martin, C.E.; Shaver, J.A.; Leon, D.F.; Thompson, M.E.; Reddy, P.S.; Leonard, J.J.","year":"1974","unstructured":"Martin CE, Shaver JA, Leon DF, Thompson ME, Reddy PS, Leonard JJ. Autonomic mechanisms in hemodynamic responses to isometric exercise. J Clin Invest 1974; 54: 104-15.","journal-title":"J Clin Invest"},{"key":"ref_8","first-page":"1","article-title":"Cardiovascular adjustment to somatomotor activation: elicitation of increments in heart rate, aortic pressure and venomotor tone with the initiation of muscle contraction","volume":"342","author":"Freyschuss, U.","year":"1970","unstructured":"Freyschuss U. Cardiovascular adjustment to somatomotor activation: elicitation of increments in heart rate, aortic pressure and venomotor tone with the initiation of muscle contraction. Acta Physiol Scand 1970; (suppl 342): 1-63.","journal-title":"Acta Physiol Scand"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1152\/jappl.1970.28.6.758","article-title":"Elicitation of heart rate and blood pressure increase on muscle contraction","volume":"28","author":"Freyschuss, U.","year":"1970","unstructured":"Freyschuss U. Elicitation of heart rate and blood pressure increase on muscle contraction. J Appl Physiol 1970; 28: 758-61.","journal-title":"J Appl Physiol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1152\/jappl.1970.29.6.794","article-title":"Instantaneous cardiac acceleration in man induced by a voluntary muscle contraction","volume":"29","author":"Petro, J.K.; Hollander, A.P.; Bouman, L.N.","year":"1970","unstructured":"Petro JK, Hollander AP, Bouman LN. Instantaneous cardiac acceleration in man induced by a voluntary muscle contraction. J Appl Physiol 1970; 29: 794-8.","journal-title":"J Appl Physiol"},{"key":"ref_11","series-title":"Proceedings of the Second Panamerican Congress of Diseases of the Chest, Rio de Janeiro","first-page":"25","article-title":"Autonomic regulation of heart rate during exercise (dynamic and isometric)","author":"Maciel, B.C.; L, Jr, Gallo; Marin-Neto, J.A.; Amorim, D.S.; Mango, J.C.","year":"1980","unstructured":"Maciel BC, Gallo L Jr, Marin-Neto JA, Amorim DS, Mango JC. Autonomic regulation of heart rate during exercise (dynamic and isometric) [Abstract]. In: Proceedings of the Second Panamerican Congress of Diseases of the Chest, Rio de Janeiro, 1980:25-6."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0002-9149(66)90051-8","article-title":"Effects of intravenous propranolol on the systemic circulatory response to sustained handgrip","volume":"18","author":"MacDonald, H.R.; Sapru, R.P.; Taylor, S.H.; Donald, K.W.","year":"1966","unstructured":"MacDonald HR, Sapru RP, Taylor SH, Donald KW. Effects of intravenous propranolol on the systemic circulatory response to sustained handgrip. Am J Cardiol 1966; 18: 333-44.","journal-title":"Am J Cardiol"},{"issue":"48","key":"ref_13","first-page":"156","article-title":"Cardiovascular responses to handgrip isometric exercise in patients following cardiac transplantation","volume":"1981","author":"Haskell, W.L.; Savin, W.M.; Schroeder, J.S.","unstructured":"Haskell WL, Savin WM, Schroeder JS, et al. Cardiovascular responses to handgrip isometric exercise in patients following cardiac transplantation. Circ Res 1981; 48 (suppl 1): 156-61.","journal-title":"Circ Res"},{"key":"ref_14","first-page":"413","article-title":"Static exercise in untreated systemic hypertension","volume":"7","author":"Ewing, D.J.; Irving, J.B.; Kerr, F.; Kirby, B.J.","year":"1973","unstructured":"Ewing DJ, Irving JB, Kerr F, Kirby BJ. Static exercise in untreated systemic hypertension. Br Heart 7 1973; 35: 413-21.","journal-title":"Br Heart"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/cs0460295","article-title":"Cardiovascular responses to sustained hand grip in normal subjects and in patients with diabetes mellitus: a test of autonomic function","volume":"46","author":"Ewing, D.J.; Irving, J.B.; Kerr, F.; Wildsmith, J.A.W.; Clarke, B.F.","year":"1974","unstructured":"Ewing DJ, Irving JB, Kerr F, Wildsmith JAW, Clarke BF. Cardiovascular responses to sustained hand grip in normal subjects and in patients with diabetes mellitus: a test of autonomic function. Clin Sci 1974; 46: 295-306.","journal-title":"Clin Sci"},{"issue":"39 44","key":"ref_16","article-title":"Adrenergic responses to sustained hand grip in patients with juvenile onset-type diabetes mellitus","volume":"49","author":"Nazar, K.; Taton, J.; Chwalbinska-Moneta, J.; Brzezinka, Z.","year":"1975","unstructured":"Nazar K, Taton J, Chwalbinska-Moneta J, Brzezinka Z. Adrenergic responses to sustained hand grip in patients with juvenile onset-type diabetes mellitus. Clin Sci 1975; 49: 39 44.","journal-title":"Clin Sci"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/cs0560287","article-title":"Heart-rate response to sustained hand grip: comparison of the effects of cardiac autonomic blockade and diabetic autonomic neuropathy","volume":"56","author":"Hume, L.; Ewing, D.J.; Campbell, I.W.; Reuben, SR, Clarke; B.F.","year":"1979","unstructured":"Hume L, Ewing DJ, Campbell IW, Reuben SR, Clarke BF. Heart-rate response to sustained hand grip: comparison of the effects of cardiac autonomic blockade and diabetic autonomic neuropathy. Clin Sci 1979; 56: 287-91.","journal-title":"Clin Sci"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0140-6736(81)92863-4","article-title":"Is there autonomic impairment in congestive (dilated) cardiomyopathy?","volume":"i:","author":"Amorim, D.S.; Dargie, H.; Heer, K.","year":"1981","unstructured":"Amorim DS, Dargie H, Heer K, et al. Is there autonomic impairment in congestive (dilated) cardiomyopathy? Lancet 1981; i: 525-7.","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/01.CIR.38.2.289","article-title":"Effects of acute elevation in blood pressure and of atropine on heart rate in Chagas'","volume":"38","author":"Amorim, D.S.; Godoy, R.A.; Mango, J.C.; Tanaka, A.; L, Jr, Gallo","year":"1968","unstructured":"Amorim DS, Godoy RA, Mango JC, Tanaka A, Gallo L Jr. Effects of acute elevation in blood pressure and of atropine on heart rate in Chagas' disease. Circulation 1968; 38: 289-94.","journal-title":"disease. Circulation"},{"issue":"40","key":"ref_20","first-page":"879","article-title":"Degeneration of the cardiac nerves in Chagas'","volume":"1969","author":"Manco, J.C.; L, Jr, Gallo; Godoy, R.A.; Fernandes, R.G.; Amorim, D.S.","unstructured":"Manco JC, Gallo L Jr, Godoy RA, Fernandes RG, Amorim DS. Degeneration of the cardiac nerves in Chagas' disease. Circulation 1969; 40: 879-85.","journal-title":"disease. Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000169713","article-title":"Abnormal heart rate responses during exercise in patients with Chagas'","volume":"60","author":"L, Jr, Gallo; JA, Marin Neto; JC, Mango; A, Rassi; DS, Amorim","year":"1975","unstructured":"Gallo L Jr, Marin Neto JA, Mango JC, Rassi A, Amorim DS. Abnormal heart rate responses during exercise in patients with Chagas' disease. Cardiology 1975; 60: 147-62.","journal-title":"disease. Cardiology"},{"key":"ref_22","first-page":"343","article-title":"Postural reflexes in chronic Chagas'","volume":"60","author":"JA, Marin Neto; L, Jr, Gallo; JC, Mango; A, Rassi; DS, Amorim","year":"1975","unstructured":"Marin Neto JA, Gallo L Jr, Mango JC, Rassi A, Amorim DS. Postural reflexes in chronic Chagas' heart disease. Cardiology 1975; 60: 343-57.","journal-title":"heart disease. Cardiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/cvr\/14.9.541","article-title":"Mechanisms of tachycardia on standing: studies in normal individuals and in chronic Chagas' heart patients","volume":"14","author":"JA, Marin Neto; L, Jr, Gallo; JC, Mango; A, Rassi; DS, Amorim","year":"1980","unstructured":"Marin Neto JA, Gallo L Jr, Mango JC, Rassi A, Amorim DS. Mechanisms of tachycardia on standing: studies in normal individuals and in chronic Chagas' heart patients. Cardiovasc Res 1980; 14: 541-50.","journal-title":"Cardiovasc Res"},{"key":"ref_24","first-page":"48","article-title":"Chagas' heart disease as an experimental model for studies of cardiac autonomic function","volume-title":"man. Mayo Clin Proc","volume":"57","author":"Amorim, D.S.; Manco, J.C.; L, Jr, Gallo; Marin-Neto, J.A.","year":"1982","unstructured":"Amorim DS, Manco JC, Gallo L Jr, Marin-Neto JA. Chagas' heart disease as an experimental model for studies of cardiac autonomic function in man. Mayo Clin Proc 1982; 57 (suppl): 48-60."},{"key":"ref_25","first-page":"171","article-title":"Subtle cardiac autonomic impairment in Chagas' disease detected by baroreflex sensitivity testing","volume":"18","author":"LF, Jr, Junqueira; L, Jr, Gallo; JC, Mango; JA, Marin Neto; DS, Amorim","year":"1985","unstructured":"Junqueira LF Jr, Gallo L Jr, Mango JC, Marin Neto JA, Amorim DS. Subtle cardiac autonomic impairment in Chagas' disease detected by baroreflex sensitivity testing. Braz J Med Biol Res 1985; 18: 171-8.","journal-title":"Braz J Med Biol Res"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/01.CIR.44.6.982","article-title":"Effect of sustained isometric handgrip exercise on left ventricular performance","volume":"44","author":"Helfant, R.H.; de Villa, M.A.; Meister, S.G.","year":"1971","unstructured":"Helfant RH, de Villa MA, Meister SG. Effect of sustained isometric handgrip exercise on left ventricular performance. Circulation 1971; 44: 982-93.","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0002-8703(74)90345-7","article-title":"An analysis of the left ventricular response to isometric exercise","volume":"88","author":"Quinones, M.A.; Gaasch, W.H.; Waisser, E.; Thiel, H.G.; Alexander, J.K.","year":"1974","unstructured":"Quinones MA, Gaasch WH, Waisser E, Thiel HG, Alexander JK. An analysis of the left ventricular response to isometric exercise. Am Heart J 1974; 88: 29-36.","journal-title":"Am Heart J"},{"key":"ref_28","first-page":"15","article-title":"Taylor SH, Stauton HP. Cardiovascular responses to sustained static contractions","volume":"1","author":"Donald, K.W.; Lind, A.R.; McNicol, G.W.; Humphreys, P.W.","year":"1967","unstructured":"Donald KW, Lind AR, McNicol GW, Humphreys PW, Taylor SH, Stauton HP. Cardiovascular responses to sustained static contractions. Circ Res 1967; 20 (suppl 1): 15-30.","journal-title":"Circ Res"},{"issue":"48","key":"ref_29","first-page":"2019","article-title":"Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man","volume":"1969","author":"Jose, A.D.","unstructured":"Jose AD. Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man. J Clin Invest 1969; 48: 2019-31.","journal-title":"J Clin Invest"},{"key":"ref_30","first-page":"303","article-title":"Pharmacological blockade of the cardiac parasympathetic system with atropine: efficacy and duration","volume":"18","author":"Maciel, B.C.; L, Jr, Gallo; Marin-Neto, J.A.; Terra-Filho, J.; Mango, J.C.","year":"1985","unstructured":"Maciel BC, Gallo L Jr, Marin-Neto JA, Terra-Filho J, Mango JC. Pharmacological blockade of the cardiac parasympathetic system with atropine: efficacy and duration. Braz J Med Biol Res 1985; 18: 303-8.","journal-title":"Braz J Med Biol Res"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/gut.4.4.399","article-title":"Enteromegaly and cardiomegaly in Chagas'","volume":"4","author":"Koberle, F.","year":"1963","unstructured":"Koberle F. Enteromegaly and cardiomegaly in Chagas' disease. Gut 1963; 4: 399-405.","journal-title":"disease. Gut"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.CIR.31.2.273","article-title":"The pathologic lesions of the cardiac autonomic nervous system in chronic Chagas'","volume":"31","author":"Mott, K.E.; Hagstrom, J.W.C.","year":"1965","unstructured":"Mott KE, Hagstrom JWC. The pathologic lesions of the cardiac autonomic nervous system in chronic Chagas' myocarditis. Circulation 1965; 31: 273-86.","journal-title":"myocarditis. Circulation"},{"key":"ref_33","first-page":"432","article-title":"Apical aneurysm of Chagas'","volume":"46","author":"Oliveira, J.S.M.; de Oliveira, J.A.M.; U, Jr, Frederigue; Lima-Filho, E.C.","year":"1981","unstructured":"Oliveira JSM, de Oliveira JAM, Frederigue U Jr, Lima-Filho EC. Apical aneurysm of Chagas' heart disease. Br Heart J 1981; 46: 432-7.","journal-title":"heart disease. Br Heart J"},{"key":"ref_34","first-page":"431","article-title":"Chagas' heart disease. First demonstrable correlation between neuronal degeneration and autonomic impairment","volume":"28","author":"Amorim, D.S.; Oliveira, J.A.M.; Mango, J.C.; L, Jr, Gallo; Oliveira, J.S.M.","year":"1973","unstructured":"Amorim DS, Oliveira JAM, Mango JC, Gallo L Jr, Oliveira JSM. Chagas' heart disease. First demonstrable correlation between neuronal degeneration and autonomic impairment. Acta Cardiol (Brux) 1973; 28: 431-40.","journal-title":"Acta Cardiol (Brux)"},{"key":"ref_35","first-page":"442","article-title":"Cardiorespiratory adjustments during dynamic exercise in normal subjects and in chronic chagasic patients","volume":"17","author":"Morelo-Filho, J.; L, Jr, Gallo; Maciel, B.C.","year":"1984","unstructured":"Morelo-Filho J, Gallo L Jr, Maciel BC, et al. Cardiorespiratory adjustments during dynamic exercise in normal subjects and in chronic chagasic patients [Abstract]. Braz J Med Biol Res 1984; 17: 442.","journal-title":"Braz J Med Biol Res"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/cs0600139","article-title":"Influence of sympatholytic drugs on the cardiovascular response to isometric exercise","volume":"60","author":"Watt, S.J.; Thomas, R.D.; Belfield, P.W.; Goldstraw, P.W.; Taylor, S.H.","year":"1981","unstructured":"Watt SJ, Thomas RD, Belfield PW, Goldstraw PW, Taylor SH. Influence of sympatholytic drugs on the cardiovascular response to isometric exercise. Clin Sci 1981; 60: 139-43.","journal-title":"Clin Sci"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.0954-6820.1970.tb08074.x","article-title":"Haemodynamic responses to sustained handgrip in patients with hypertension","volume":"188","author":"Hoel, B.L.; Lorentsen, E.; Lund-Larsen, P.C.","year":"1970","unstructured":"Hoel BL, Lorentsen E, Lund-Larsen PC. Haemodynamic responses to sustained handgrip in patients with hypertension. Acta Med Scand 1970; 188: 491-8.","journal-title":"Acta Med Scand"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1136\/hrt.35.4.422","article-title":"Haemodynamic responses to isometric exercise (handgrip) in patients with heart disease","volume":"35","author":"Fisher, M.L.; Nutter, D.O.; Jacobs, W.; Schiant, R.C.","year":"1973","unstructured":"Fisher ML, Nutter DO, Jacobs W, Schiant RC. Haemodynamic responses to isometric exercise (handgrip) in patients with heart disease. Br Heart J 1973; 35: 422-32.","journal-title":"Br Heart J"},{"issue":"48","key":"ref_39","first-page":"138","article-title":"Direct and noninvasive evaluation of the cardiovascular response to isometric exercise","volume":"1981","author":"Perez-Gonzales, J.F.; Schiller, N.B.; Parmley, W.W.","unstructured":"Perez-Gonzales JF, Schiller NB, Parmley WW. Direct and noninvasive evaluation of the cardiovascular response to isometric exercise. Circ Res 1981; 48 (suppl 1): 138-48.","journal-title":"Circ Res"},{"key":"ref_40","article-title":"Estudo da reserva cardiaca em pacientes assintomaticos portadores da doenqa de Chagas na sua forma cr6nica, submetidos ao exercicio isometrico continuo","author":"Galiano, N.E.","year":"1983","unstructured":"Galiano NE, Estudo da reserva cardiaca em pacientes assintomaticos portadores da doenqa de Chagas na sua forma cr6nica, submetidos ao exercicio isometrico continuo. Ribeirao Preto (SP): Universidade de Sao Paulo, 1983. Thesis."}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.55.2.204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T02:36:41Z","timestamp":1737427001000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.55.2.204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2,1]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,2,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.55.2.204","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1986,2,1]]}}}