{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:16:11Z","timestamp":1789146971453,"version":"build-2803163510"},"reference-count":27,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1987,3,1]]},"DOI":"10.1136\/hrt.57.3.270","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"270-278","source":"Crossref","is-referenced-by-count":126,"title":["Treatment of primary pulmonary hypertension intravenous epoprostenol (prostacyclin)."],"prefix":"10.1136","volume":"57","author":[{"given":"D K","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T W","family":"Higenbottam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Wallwork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"7","article-title":"Primary pulmonary hypertension: report on a WHO meeting","volume":"1975","author":"Hatano, S.","unstructured":"Hatano S, Strasser T, eds. Primary pulmonary hypertension: report on a WHO meeting. Geneva: World Health Organisation, 1975:7.","journal-title":"Geneva: World Health Organisation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.CIR.56.5.884","article-title":"Clinical primary pulmonary hypertension: 3 pathologic types","volume":"56","author":"Edwards, W.D.; Edwards, J.E.","year":"1977","unstructured":"Edwards WD, Edwards JE. Clinical primary pulmonary hypertension: 3 pathologic types. Circulation 1977;56:884-8.","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/0002-9149(73)90814-X","article-title":"Intrapulmonary veno-occlusive disease","volume":"31","author":"Rosenthal, A.; Vawter, G.; Wagenvoort, C.A.","year":"1973","unstructured":"Rosenthal A, Vawter G, Wagenvoort CA. Intrapulmonary veno-occlusive disease. Am J Cardiol 1973;31:78-83.","journal-title":"Am J Cardiol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.CIR.70.4.580","article-title":"Primary pulmonary hypertension: natural history and the importance of thrombosis","volume":"70","author":"Fuster, V.; Steele, P.M.; Edwards, W.D.; Gersh, B.J.; McGoon, M.D.; Frye, R.L.","year":"1984","unstructured":"Fuster V, Steele PM, Edwards WD, Gersh BJ, McGoon MD, Frye RL. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation 1984;70:580-7.","journal-title":"Circulation"},{"key":"ref_5","first-page":"241","article-title":"Pulmonary hypertension","volume-title":"Oxford textbook of medicine","volume":"13","author":"Honey, M.","unstructured":"Honey M. Pulmonary hypertension. In: Weatherall DJ, Ledingham JG, Warrell DA, eds. Oxford textbook of medicine. Oxford: Oxford University Press, 1983; Vol II, 13. 241."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1056\/NEJM198001103020204","article-title":"Diazoxide in primary pulmonary hypertension","volume":"302","author":"Klinke, W.P.; Gilbert, J.A.L.","year":"1980","unstructured":"Klinke WP, Gilbert JAL. Diazoxide in primary pulmonary hypertension. N Engl J Med 1980;302:91-2.","journal-title":"N Engl J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM198001103020201","article-title":"Oral hydralazine therapy for primary pulmonary hypertension","volume":"302","author":"Rubin, L.J.; Peter, R.H.","year":"1980","unstructured":"Rubin LJ, Peter RH. Oral hydralazine therapy for primary pulmonary hypertension. N Engl J Med 1980;302:69-73.","journal-title":"N Engl J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJM198206033062203","article-title":"Deleterious effects of hydralazine in patients with pulmonary hypertension","volume":"306","author":"Packer, M.; Greenberg, B.; Massie, B.; Dash, H.","year":"1982","unstructured":"Packer M, Greenberg B, Massie B, Dash H. Deleterious effects of hydralazine in patients with pulmonary hypertension. N Engl Jf Med 1982; 306:1326-31.","journal-title":"N Engl Jf Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/hrt.46.4.401","article-title":"Hazards of diazoxide in pulmonary hypertension","volume":"46","author":"Buch, J.; Wennevold, A.","year":"1981","unstructured":"Buch J, Wennevold A. Hazards of diazoxide in pulmonary hypertension. Br Heart J 1981;46:401-3.","journal-title":"Br Heart J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1161\/01.CIR.66.2.334","article-title":"Prostac'yclin-induced pulmonary vasodilation in primary pulmonary hypertension","volume":"66","author":"Rubin, L.J.; Groves, B.M.; Reeves, J.T.; Frosolano, M.; Handel, F.; Cato, A.E.","year":"1982","unstructured":"Rubin LJ, Groves BM, Reeves JT, Frosolano M, Handel F, Cato AE. Prostac'yclin-induced pulmonary vasodilation in primary pulmonary hypertension. Circulation 1982;66:334-8.","journal-title":"Circulation"},{"key":"ref_11","first-page":"1046","article-title":"Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin)","volume":"i:","author":"Higenbottam, T.; Wheeldon, D.; Wells, F.; Wallwork, J.","year":"1984","unstructured":"Higenbottam T, Wheeldon D, Wells F, Wallwork J. Long-term treatment of primary pulmonary hypertension with continuous intravenous epoprostenol (prostacyclin). Lancet 1984;i:1046-7.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0034-5687(79)90029-X","article-title":"Measurement of metabolic gas exchange and minute volume by mass spectrometry alone","volume":"36","author":"Davies, N.J.H.; Denison, D.M.","year":"1979","unstructured":"Davies NJH, Denison DM. Measurement of metabolic gas exchange and minute volume by mass spectrometry alone. Respir Physiol 1979;36:261-7.","journal-title":"Respir Physiol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2125.1982.tb01959.x","article-title":"Side effects occurring during administration of epoprostenol (prostacyclin, PG12) in man","volume":"14","author":"Pickles, H.; O'Grady, J.","year":"1982","unstructured":"Pickles H, O'Grady J. Side effects occurring during administration of epoprostenol (prostacyclin, PG12) in man. BrJ Clin Pharmacol 1982;14:177-85.","journal-title":"BrJ Clin Pharmacol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1161\/01.CIR.42.6.1163","article-title":"Primary pulmonary hypertension. A pathologic study of the lung vessels in 156 clinically diagnosed cases","volume":"42","author":"Wagenvoort, C.A.; Wagenvoort, N.","year":"1970","unstructured":"Wagenvoort CA, Wagenvoort N. Primary pulmonary hypertension. A pathologic study of the lung vessels in 156 clinically diagnosed cases. Circulation 1970; 42:1163-84.","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0002-8703(63)90034-6","article-title":"Loss of reactivity of the pulmonary vascular bed in primary pulmonary hypertension","volume":"66","author":"Samet, P.; Bernstein, W.H.","year":"1963","unstructured":"Samet P, Bernstein WH. Loss of reactivity of the pulmonary vascular bed in primary pulmonary hypertension. Am Heart J 1963;66:197-9.","journal-title":"Am Heart J"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0002-8703(83)90288-0","article-title":"Reassessment of the effects of vasodilator drugs in primary pulmonary hypertension: guidelines for determining a pulmonary vasodilator response","volume":"105","author":"Rich, S.; Martinez, J.; Lam, W.; Levy, P.S.; Rosen, K.M.","year":"1983","unstructured":"Rich S, Martinez J, Lam W, Levy PS, Rosen KM. Reassessment of the effects of vasodilator drugs in primary pulmonary hypertension: guidelines for determining a pulmonary vasodilator response. Am Heart J 1983;105:119-27.","journal-title":"Am Heart J"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-99-4-433","article-title":"Treatment of primary pulmonary hypertension with nifedipine. A haemodynamic and scintigraphic evaluation","volume":"99","author":"Rubin, L.J.; Nicod, P.; Hillis, D.; Firth, B.G.","year":"1983","unstructured":"Rubin LJ, Nicod P, Hillis D, Firth BG. Treatment of primary pulmonary hypertension with nifedipine. A haemodynamic and scintigraphic evaluation. Ann Intern Med 1983;99:433-8.","journal-title":"Ann Intern Med"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1056\/NEJM198411013111804","article-title":"Right sided infective endocarditis as a consequence of flow-directed pulmonary-artery catheterisation. A clinicopathological study of 55 autopsied patients","volume":"311","author":"Rowley, K.M.; Coni Clubb, K.; Walker Smith, G.J.; Cabin, S.","year":"1984","unstructured":"Rowley KM, Coni Clubb K, Walker Smith GJ, Cabin S. Right sided infective endocarditis as a consequence of flow-directed pulmonary-artery catheterisation. A clinicopathological study of 55 autopsied patients. N Engl J Med 1984;311:1152-6.","journal-title":"N Engl J Med"},{"key":"ref_19","first-page":"272","article-title":"Captopril as treatment for patients with pulmonary hypertension: problem of variability in assessing chronic drug treatment","volume-title":"Br Heart Y","volume":"48","author":"Rich, S.; Martinez, J.; Lam, W.; Rosen, K.M.","year":"1982","unstructured":"Rich S, Martinez J, Lam W, Rosen KM. Captopril as treatment for patients with pulmonary hypertension: problem of variability in assessing chronic drug treatment. Br Heart Y 1982;48:272-7."},{"key":"ref_20","first-page":"32","article-title":"Clinical exercise testing","author":"Jones, N.L.; Campbell, E.J.M.","year":"1982","unstructured":"Jones NL, Campbell EJM. Clinical exercise testing. London: WB Saunders, 1982:32-4."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/01.CIR.65.6.1213","article-title":"Oxygen utilisation and ventilation during exercise in patients with chronic cardiac failure","volume":"65","year":"1982","unstructured":"Oxygen utilisation and ventilation during exercise in patients with chronic cardiac failure. Circulation 1982;65:1213-23.","journal-title":"Circulation"},{"key":"ref_22","first-page":"380","article-title":"Non-invasive assessment of hemodynamic improvement during chronic vasodilator therapy in obliterative pulmonary hypertension","volume":"133","year":"1986","unstructured":"D'Alonzo GE, Gianotti L, Dantzker DR. Non-invasive assessment of hemodynamic improvement during chronic vasodilator therapy in obliterative pulmonary hypertension. Am Rev Respir Dis 1986; 133:380-4.","journal-title":"Am Rev Respir Dis"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/hrt.50.6.579","article-title":"Haemodynamic response to intravenous hydralazine in patients with pulmonary hypertension","volume":"50","author":"McGoon, M.D.; Seward, J.B.; Vlietstra, R.E.; Choo, M.H.; Moyer, T.P.; Reeder, G.S.","year":"1983","unstructured":"McGoon MD, Seward JB, Vlietstra RE, Choo MH, Moyer TP, Reeder GS. Haemodynamic response to intravenous hydralazine in patients with pulmonary hypertension. Br Heart J 1983;50:579-85.","journal-title":"Br Heart J"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/01.CIR.65.4.651","article-title":"Unexplained pulmonary hypertension","volume":"65","author":"Fishman, A.P.","year":"1982","unstructured":"Fishman AP. Unexplained pulmonary hypertension. Circulation 1982;65:651-2.","journal-title":"Circulation"},{"key":"ref_25","first-page":"1261","article-title":"Vasodilator therapy for pulmonary hypertension","volume":"302","author":"Reeves, J.T.","year":"1980","unstructured":"Reeves JT. Vasodilator therapy for pulmonary hypertension [Letter]. N Engl J Med 1980;302:1261-2.","journal-title":"N Engl J Med"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/hrt.53.1.1","article-title":"Management of primary pulmonary hypertension","volume":"53","author":"Oakley, C.M.","year":"1985","unstructured":"Oakley CM. Management of primary pulmonary hypertension. Br Heart J 1985;53:1-4.","journal-title":"Br Heart J"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(84)92672-2","article-title":"Rebound platelet activation during continuous epoprostenol infusion","volume":"ii:","author":"Sinzinger, H.; Leithner, C.; Silberbauer, K.","year":"1984","unstructured":"Sinzinger H, Leithner C, Silberbauer K. Rebound platelet activation during continuous epoprostenol infusion. Lancet 1984;ii:759.","journal-title":"Lancet"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.57.3.270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T01:01:46Z","timestamp":1601082106000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.57.3.270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3,1]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.57.3.270","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1987,3,1]]}}}